The mission of the Claridge-Chang lab is to develop and use Drosophila behavioral neurogenetic methods to better understand basic brain functions that are disrupted in common mental disorders. We are particularly interested in aversive associative learning, defense behaviors, feeding, and other emotional behaviors, including the role of the conserved neuromodulatory pathways involved in these processes. The lab has expertise in genetics, behavior experiments, instrumentation development, neuroanatomy, estimation statistics, meta-analysis, optogenetics, and related methods.
The lab webpage and Adam's ORCID page have more details about our research. The lab is hosted by the Institute for Molecular and Cell Biology. Adam is the President of the Singapore Chapter of the Society for Neuroscience.
The lab has developed a free, user-friendly web app to help scientists with the analysis of experimental data.
Concordance and incongruence in preclinical anxiety models: systematic review and meta-analyses
Farhan Mohammad, Joses Ho, Chun Lei Lim, Jia Hern Woo, Dennis Jun Jie Poon, Bhumika
Lamba, Adam Claridge-Chang
Neuroscience and Biobehavioral Reviews. 2016
• More than 1000 pdf downloads from bioRxiv
Ancient anxiety pathways influence Drosophila defense behaviors
Farhan Mohammad, Sameer Aryal, Joses Ho, James Charles Stewart, Nurul Ayuni Norman,
Tan Teng Li, Agnese Eisaka & Adam Claridge-Chang
Current Biology. 2016
• Highlighted in Asian Scientist, Medical Daily, Trends der Zukunft, A*STAR Research and others.
Drosophila learn efficient paths to a food source
Rapeechai Navawongse, Deepak Choudhury, Marlena Raczkowska, James Charles Stewart,
Terrence Lim, Mashiur Rahman, Alicia Guek Geok Toh, Zhiping Wang, Adam Claridge-
Neurobiology of Learning and Memory. 2016
Mouse pose estimation from depth images
Ashwin Nanjappa, Li Cheng, Wei Gao, Chi Xu, Adam Claridge-Chang, Zoe Bichler
Estimating information processing through a memory system: the utility of
meta-analytic methods for genetics
Tugce Yildizoglu, Jan-Marek Weislogel, Farhan Mohammad, Edwin S.-Y. Chan, Pryseley N.
Assam, Adam Claridge-Chang
PLOS Genetics. 2015
• Highlighted in A*STAR Research.
claridge-chang curriculum vitæ – page 1
The right dorsal habenula limits attraction to an odor in zebrafish
Seetha Krishnan, Ajay S. Mathuru, Caroline Kibat, Mashiur Rahman, Charlotte Lupton,
James Stewart, Adam Claridge-Chang, Shih-Chen Yen, Suresh Jesuthasan
Current Biology. 2014
Selected review and opinion
Estimation statistics should replace significance testing
Adam Claridge-Chang and Pryseley N. Assam
Nature Methods. 2016
The surveillance state of behavioral automation
Andreas T. Schaefer and Adam Claridge-Chang
Current Opinion in Neurobiology. 2012