The mission of the Claridge-Chang lab is to develop and use Drosophila behavioral neurogenetic methods to better understand basic brain functions that are disrupted in common mental disorders. We are particularly interested in aversive associative learning, defense behaviors, feeding, and other emotional behaviors, including the role of the conserved neuromodulatory pathways involved in these processes. The lab has expertise in genetics, behavior experiments, instrumentation development, neuroanatomy, estimation statistics, meta-analysis, optogenetics, and related methods.
The lab webpage and Adam's ORCID page have more details about our research. The lab is hosted by the Institute for Molecular and Cell Biology. Adam is the President of the Singapore Chapter of the Society for Neuroscience.
The lab has developed a free, user-friendly web app to help scientists with the analysis of experimental data.
Kalium channelrhodopsins effectively inhibit neurons in the small model animals
Stanislav Ott, Sangyu Xu, Nicole Lee, Ivan Hee Kean Hong, Jonathan Anns, Danesha Devini Suresh, Zhiyi Zhang, Xianyuan Zhang, Raihanah Harion, Weiying Vivian Ye, Vaishnavi Chandramouli, Suresh J Jesuthasan, Yasunori Saheki, Adam Claridge-Chang
Biorxiv 2024.
A dopaminergic memory circuit controls acute valence
Farhan Mohammad, Yishan Mai, Joses Ho, Xianyuan Zhang, Stanislav Ott, James Charles Stewart, Adam Claridge-Chang
Biorxiv 2022.
Genomic patterns of divergence in the early and late steps of speciation of the deep-sea vent thermophilic worms of the genus Alvinella
Camille Thomas–Bulle, Denis Bertrand, Niranjan Nagarajan, Richard Copley, Erwan Corre, Stéphane Hourdez, Éric Bonnivard, Adam Claridge-Chang, Didier Jollivet
BMC Ecology and Evolution. 2022.
Clearing the air on Covid-19 transmission
The Straits Times. Feb 2022
Most primary olfactory neurons have individually neutral effects on behavior
Tayfun Tumkaya, Safwan Burhanudin, Asghar Khalilnezhad, James Stewart, Hyungwon Choi, Adam Claridge-Chang
eLife 2022. Data available at Zenodo.
China’s ‘zero Covid’ vs Singapore’s ‘living with it’: rapid low-cost testing could mean we don’t need to choose
South China Morning Post. Oct 2021
Dengue virus infection modifies mosquito blood-feeding behavior to increase transmission to the host
Benjamin Wong Wei Xiang, Wilfried A. A. Saron, James Charles Stewart, Arthur Hain, Varsha Walvekar, Dorothée Missé, Fréderic Thomas, R. Manjunatha Kini, Benjamin Roche, Adam Claridge-Chang, Ashley L. St John, Julien Pompon
PNAS 2022.
A neural m6A/YTHDF pathway is required for learning and memory in Drosophila
Lijuan Kan, Stanislav Ott, Brian Joseph, Eun Sil Park, Crystal Dai, Ralph Kleiner, Adam Claridge-Chang, Eric C. Lai
Nature Communications 2021.
Neurons that function within an integrator to promote a persistent behavioral state in Drosophila
Yonil Jung, Ann Kennedy, Hui Chiu, Farhan Mohammad, Adam Claridge-Chang, David J. Anderson
Neuron 2020.
Moving beyond P values: Data analysis with estimation plots
Joses Ho, Tayfun Tumkaya, Sameer Aryal, Hyungwon Choi, Adam Claridge-Chang
Nature Methods 2019.