Directory

Design and analysis of clinical and population health studies
Professor Cheung and his team have been investigating innovative, efficient and robust approaches to study designs and their associated analytic methods, covering individual and cluster randomized trials, case-control and case-only studies, and real-world evidence research. These developments have been motivated by and applied to studies of global child health, vaccine, and palliative care.

Analysis of recurrent time-to-event and incidence data
Recent developments in vaccines and pharmaceutical prevention measures often involve conditions that can recur, such as acute gastroenteritis and pneumonia, as opposed to diseases that can only occur once in a lifetime. Health services research also often involve recurrent event outcomes, such as emergency department visits and hospital readmissions. Conventional analytic methods that are oriented to studying a single event or first event is not sufficient. Methods to analyse recurrent event data is a key research area of the team. 

Global child health
The first 1000 days of a child's life is an important yet delicate period for their health and long-term development. Professor Cheung has been studying fetal and child growth, development, and infectious diseases in Asia and Africa. He also evaluates the impact of nutritional supplementation and vaccination on child health, especially pneumococcal and malaria vaccination.      

Quality of life and health utility amid life-limiting illness
Professor Cheung and his team develop and evaluate methods and measurement scales to quantify patients’ and caregivers’ quality of life and health utility, with focus on suitability and usability in Asian and clinical settings. Some recent achievements include the development of the Singapore Caregiver Quality of Life Scale and its short forms and sample size determination formula for EQ-5D-5L value set studies. They also study factors that affect and interventions that improve health and quality of life outcomes of patients with palliative or long-term care needs and their caregivers.

Association between psychological symptoms in adults and growth in early life: longitudinal follow up study.

BMJ (Clinical research ed.) – Cheung Y B; Khoo K S; Karlberg J; Machin D (2002)

325 (7367);

Developmental potential in the first 5 years for children in developing countries.

Lancet (London, England) – Grantham-McGregor Sally; Cheung Yin Bun; Cueto Santiago; Glewwe Paul; Richter Linda; Strupp Barbara; (2007)

369 (9555); 60-70

Nasopharyngeal carriage of Streptococcus pneumoniae in Gambian children who participated in a 9-valent pneumococcal conjugate vaccine trial and in their younger siblings.

The Pediatric infectious disease journal – Cheung Yin-Bun; Zaman Syed M A; Nsekpong Ekpedeme David; Van Beneden Chris A; Adegbola Richard A; Greenwood Brian; Cutts Felicity T (2009)

28 (11); 990-5

Child Health Outcomes After Presumptive Infection Treatment in Pregnant Women: A Randomized Trial.

Pediatrics – Hallamaa Lotta; Cheung Yin Bun; Maleta Kenneth; Luntamo Mari; Ashorn Ulla; Gladstone Melissa; Kulmala Teija; Mangani Charles; Ashorn Per (2018)

141 (3);

Timeliness of Childhood Vaccination Coverage: the Growing Up in Singapore Towards Healthy Outcomes Study.

Prevention science : the official journal of the Society for Prevention Research – Loy See Ling; Cheung Yin Bun; Chan Jerry Kok Yen; Soh Shu E; Godfrey Keith M; Tan Kok Hian; Shek Lynette Pei-Chi; Chong Yap-Seng; Lek Ngee; Yap Fabian; Teoh Oon Hoe; Yung Chee Fu; Thoon Koh Cheng (2020)

21 (3); 283-292

Zero-inflated models for regression analysis of count data: a study of growth and development.

Statistics in medicine – Cheung Yin Bin (2002)

21 (10); 1461-9

Estimation of intervention effects using first or multiple episodes in clinical trials: The Andersen-Gill model re-examined.

Statistics in medicine – Cheung Yin Bun; Xu Ying; Tan Sze Huey; Cutts Felicity; Milligan Paul (2010)

29 (3); 328-36

Statistical estimation of antibody concentration using multiple dilutions.

Journal of immunological methods – Cheung Yin Bun; Xu Ying; Remarque Edmond J; Milligan Paul (2015)

417 115-123

Semiparametric estimation of time-varying intervention effects using recurrent event data.

Statistics in medicine – Xu Jiajun; Lam K F; Chen Feng; Milligan Paul; Cheung Yin Bun (2017)

36 (17); 2682-2696

Statistical inference in matched case-control studies of recurrent events.

International journal of epidemiology – Cheung Yin Bun; Ma Xiangmei; Lam K F; Li Jialiang; Yung Chee Fu; Milligan Paul; Mackenzie Grant (2020)

49 (3); 996-1006

Variability and sample size requirements of quality-of-life measures: a randomized study of three major questionnaires.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology – Cheung Yin-Bun; Goh Cynthia; Thumboo Julian; Khoo Kei-Siong; Wee Joseph (2005)

23 (22); 4936-44

Trajectory of quality of life for poor prognosis stage 5D chronic kidney disease with and without dialysis.

American journal of nephrology – Seow Ying-Ying; Cheung Yin Bun; Qu Li Min; Yee Alethea Chung Pheng (2013)

37 (3); 231-8

Mean Rank, Equipercentile, and Regression Mapping of World Health Organization Quality of Life Brief (WHOQOL-BREF) to EuroQoL 5 Dimensions 5 Levels (EQ-5D-5L) Utilities.

Medical decision making : an international journal of the Society for Medical Decision Making – Wee Hwee Lin; Yeo Khung Keong; Chong Kok Joon; Khoo Eric Yin Hao; Cheung Yin Bun (2018)

38 (3); 319-333

Development and evaluation of a quality of life measurement scale in English and Chinese for family caregivers of patients with advanced cancers.

Health and quality of life outcomes – Cheung Yin Bun; Neo Shirlyn H S; Teo Irene; Yang Grace M; Lee Geok Ling; Thumboo Julian; Chia John W K; Koh Audrey R X; Qu Debra L M; Che William W L; Lau Annie; Wee Hwee Lin (2019)

17 (1);

Two valid and reliable short forms of the Singapore caregiver quality of life scale were developed: SCQOLS-10 and SCQOLS-15.

Journal of clinical epidemiology – Cheung Yin Bun; Neo Shirlyn H S; Yang Grace M; Lee Geok Ling; Teo Irene; Koh Audrey R X; Thumboo Julian; Wee Hwee Lin (2020)

121 101-108