Tham C.Y., Poon L.F.,…Osato M. and Li S. High-throughput telomere length measurement at nucleotide resolution using the PacBio high fidelity sequencing platform. Nat. Comm. 2023 Jan 17 14(1):281. doi: 10.1038/s41467-023-35823-7
Nargund A.M.,… Li S.* and Tan P.* (Co-corresponding author) Chromatin Alterations Driven by MSH2 Deficiency Confer Cell Adhesion Deregulation and Sensitivity to BET Inhibition. 2022 Cancer Research 82(14):2538-2551 doi: 10.1158/0008-5472.CAN-21-2072
Fan X,…Li S, …Low A. CXCL5 administration dampens inflammation and improves survival in murine lupus via myeloid and neutrophil pathways. Arthritis & Rheumatology 2022 Oct 14 doi:10.1002/art.42383
Cai Y., …Li S, ... and Fullwood M.J. H3K27me3-rich genomic regions can function as silencers to repress gene expression via chromatin interaction. 2021 Nature Communications 12:1 doi: 10.1038/s41467-021-20940-y.
Choo, XY,… Li S,... and Rackham O.J.L. Evaluating capture sequence performance for single-cell CRISPR activation experiments. ACS Synthetic Biology 2021 10(3), 640-645. doi:10.1021/acssynbio.0c00499.
Xing M…Li S, Teh BT, and Tan P Genomic and epigenomic EBF1 alterations modulate Tert expression in gastric cancer. Journal of Clinical Investigation 2020 130(6):3005-3020 doi:10.1172/JCI126726.
Yi Wei, B., Yeh ChingLin, Yeow Tee Goh, Li S., Liam Pock Ho, Tumor infiltrating lymphocytes from acute myeloid leukemia marrow can be reverted to CD45RA+ central memory state by reactivation in SIP (Simulated Infective Protocol). Immunobiology 224 (4), 526-531. (2020)
Xu, C.; Ooi, W. F.; Qamra, A.; Tan, J.; Chua, B. Y.-J.; Ho, S. W. T.; Das, K.; Adam Isa, Z. F.; Li, Z.; Yao, X.; Yan, T.; Xing, M.; Huang, K. K.; Lin, J. S.; Nandi, T.; Tay, S. T.; Lee, M. H.; Tan, A. L. K.; Ong, X.; Ashktorab, H.; Smoot, D.; Li S.; Ng, S.-C.; Teh, B. T.; Tan, P., HNF4α pathway mapping identifies wild-type IDH1 as a targetable metabolic node in gastric cancer. Gut 69 (2), 231-242. (2020)
Ooi, W. F.; Nargund, A. M.; Lim, K. J.; Zhang, S.; Xing, M.; Mandoli, A.; Lim, J. Q.; Ho, S. W. T.; Guo, Y.; Yao, X.; Lin, S. J.; Nandi, T.; Xu, C.; Ong, X.; Lee, M.; Tan, A. L.-K.; Lam, Y. N.; Teo, J. X.; Kaneda, A.; White, K. P.; Lim, W. K.; Rozen, S. G.; Teh, B. T.; Li, S.; Skanderup, A. J.; Tan, P., Integrated paired-end enhancer profiling and whole-genome sequencing reveals recurrent CCNE1 and IGF2 enhancer hijacking in primary gastric adenocarcinoma. Gut, gutjnl-2018-317612. (2019)
Cai, Y.; Zhang, Y.; Loh, Y. P.; Tng, J. Q.; Lim, M. C.; Cao, Z.; Raju, A.; Li S.; Manikandan, L.; Tergaonkar, V.; Tucker-Kellogg, G.; Fullwood, M. J., H3K27me3-rich genomic regions can function as silencers to repress gene expression via chromatin interactions. bioRxiv, 684712. (2019)
TingDong, Y.; Wen Fong, O.; Qamra, A.; Cheung, A.; Ma, D.; Gopinath Meenakshi, S.; Chang, X.; Xing, M.; Poon, L.; Wang, J.; Loh, Y. P.; Jess Hui Jie, H.; Joscelyn Jun Quan, N.; Muhammad Khairul, R.; Aswad, L.; Rozen, S. G.; Ghosh, S.; Bard, F. A.; Sampath, P.; Tergaonkar, V.; Davies, J. O. J.; Hughes, J. R.; Goh, E.; Bi, X.; Fullwood, M. J.; Tan, P.; Li S., HoxC5 and miR-615-3p target newly evolved genomic regions to repress hTERT and inhibit tumorigenesis. Nature Communications 9, 1. (2018)
Fan, X.; Guo, D.; Cheung, A. M. S.; Poon, Z. Y.; Yap, C. S.; Goh, S. E.; Guo, D.; Li, H.; Bari, S.; Li S.; Lim, K. H.; Hwang, W. Y. K., Mesenchymal Stromal Cell (MSC)-Derived Combination of CXCL5 and Anti-CCL24 Is Synergistic and Superior to MSC and Cyclosporine for the Treatment of Graft-versus-Host Disease. Biology of Blood and Marrow Transplantation 24 (10), 1971-1980. (2018)
Bari, S.; Zhong, Q.; Fan, X.; Poon, Z.; Lim, A. S. T.; Lim, T. H.; Dighe, N.; Li S.; Chiu, G. N. C.; Chai, C. L. L.; Hwang, W. Y. K., 199 - Ex Vivo Expansion of SCID-Repopulating CD34+CD90+CD49f+Hematopoietic Stem & Progenitor Cells From Non-Enriched Human Umbilical Cord Blood with Novel Azole-Based Small Molecules. Biology of Blood and Marrow Transplantation 24 (3, Supplement), S189. (2018)
Bari, S.; Zhong, Q.; Fan, X.; Poon, Z.; Lim, A. S. T.; Lim, T. H.; Dighe, N.; Li S.; Chiu, G. N. C.; Chai, C. L. L.; Hwang, W. Y. K., Ex Vivo Expansion of CD34+CD90+CD49f+ Hematopoietic Stem and Progenitor Cells from Non-Enriched Umbilical Cord Blood with Azole Compounds. STEM CELLS Translational Medicine 7 (5), 376-393. (2018)
Yao, X.; Tan, J.; Lim, K. J.; Koh, J.; Ooi, W. F.; Li, Z.; Huang, D.; Xing, M.; Chan, Y. S.; Qu, J. Z.; Tay, S. T.; Wijaya, G.; Lam, Y. N.; Hong, J. H.; Lee-Lim, A. P.; Guan, P.; Ng, M. S. W.; He, C. Z.; Lin, J. S.; Nandi, T.; Qamra, A.; Xu, C.; Myint, S. S.; Davies, J. O. J.; Goh, J. Y.; Loh, G.; Tan, B. C.; Rozen, S. G.; Yu, Q.; Tan, I. B. H.; Cheng, C. W. S.; Li S.; Chang, K. T. E.; Tan, P. H.; Silver, D. L.; Lezhava, A.; Steger, G.; Hughes, J. R.; Teh, B. T.; Tan, P., VHL Deficiency Drives Enhancer Activation of Oncogenes in Clear Cell Renal Cell Carcinoma. Cancer Discovery 7 (11), 1284. (2017)
Ramlee, M. K.; Wang, J.; Cheung, A. M. S.; Li S., Using a Fluorescent PCR-capillary Gel Electrophoresis Technique to Genotype CRISPR/Cas9-mediated Knockout Mutants in a High-throughput Format. J Vis Exp (122), 55586. (2017)
Gopalakrishnan, V.; Tan, C. R.; Li S., Sequential phosphorylation of CST subunits by different cyclin-Cdk1 complexes orchestrate telomere replication. Cell Cycle 16 (13), 1271-128. (2017)
Arya, D.; Sachithanandan, S. P.; Ross, C.; Palakodeti, D.; Li S.; Krishna, S., MiRNA182 regulates percentage of myeloid and erythroid cells in chronic myeloid leukemia. Cell death & disease 8 (1), e2547-e2547. (2017)
Ooi, W. F.; Xing, M.; Xu, C.; Yao, X.; Ramlee, M. K.; Lim, M. C.; Cao, F.; Lim, K.; Babu, D.; Poon, L.-F.; Lin Suling, J.; Qamra, A.; Irwanto, A.; Qu Zhengzhong, J.; Nandi, T.; Lee-Lim, A. P.; Chan, Y. S.; Tay, S. T.; Lee, M. H.; Davies, J. O. J.; Wong, W. K.; Soo, K. C.; Chan, W. H.; Ong, H. S.; Chow, P.; Wong, C. Y.; Rha, S. Y.; Liu, J.; Hillmer, A. M.; Hughes, J. R.; Rozen, S.; Teh, B. T.; Fullwood, M. J.; Li S.; Tan, P., Epigenomic profiling of primary gastric adenocarcinoma reveals super-enhancer heterogeneity. Nature Communications 7, 12983. (2016)
Liu, C. C.; Ma, D. L.; Yan, T.-D.; Fan, X.; Poon, Z.; Poon, L.-F.; Goh, S.-A.; Rozen, S. G.; Hwang, W. Y. K.; Tergaonkar, V.; Tan, P.; Ghosh, S.; Virshup, D. M.; Goh, E. L. K.; Li S., Distinct Responses of Stem Cells to Telomere Uncapping—A Potential Strategy to Improve the Safety of Cell Therapy. STEM CELLS 34 (10), 2471-2484. (2016)
Khattar, E.; Kumar, P.; Liu, C. Y.; Akıncılar, S. C.; Raju, A.; Lakshmanan, M.; Maury, J. J. P.; Qiang, Y.; Li S.; Tan, E. Y.; Hui, K. M.; Shi, M.; Loh, Y. H.; Tergaonkar, V., Telomerase reverse transcriptase promotes cancer cell proliferation by augmenting tRNA expression. J Clin Invest 126 (10), 4045-4060. (2016)
Ramlee, M. K.; Yan, T.; Cheung, A. M. S.; Chuah, C. T. H.; Li S., High-throughput genotyping of CRISPR/Cas9-mediated mutants using fluorescent PCR-capillary gel electrophoresis. Scientific Reports 5, 15587. (2015)
Koh, C. M.; Khattar, E.; Leow, S. C.; Liu, C. Y.; Muller, J.; Ang, W. X.; Li, Y.; Franzoso, G.; Li S.; Guccione, E.; Tergaonkar, V., Telomerase regulates MYC-driven oncogenesis independent of its reverse transcriptase activity. J Clin Invest, 125 (5), 2109-2122. (2015)
Akıncılar, S. C.; Low, K. C.; Liu, C. Y.; Yan, T. D.; Oji, A.; Ikawa, M.; Li S.; Tergaonkar, V., Quantitative assessment of telomerase components in cancer cell lines. FEBS Letters 589 (9), 974-984. (2015)
Liu, C.-C.; Gopalakrishnan, V.; Poon, L.-F.; Yan, T.; Li S., Cdk1 regulates the temporal recruitment of telomerase and Cdc13-Stn1-Ten1 complex for telomere replication. Molecular and cellular biology 34 (1), 57-70. (2014)
Xu, L.; Li S.; Stohr, B. A., The Role of Telomere Biology in Cancer. Annual Review of Pathology: Mechanisms of Disease 8 (1), 49-78. (2013)
Ho, L. P.; Yit, P. S.; Ng, L. H.; Linn, Y. C.; Zhao, Y.; Sun, L.; Ling, K. L.; Chai Koh, M. B.; Monica Shih, M.-C.; Li S.; Wang, X. Y.; Tien, S. L.; Goh, Y. T., The Road to Memory: An Early Rest for the Long Journey. The Journal of Immunology 191 (11), 5603. (2013)
Bari, S.; Chu, P. P. Y.; Lim, A.; Fan, X.; Gay, F. P. H.; Bunte, R. M.; Lim, T. K. H.; Li S.; Chiu, G. N. C.; Hwang, W. Y. K., Protective role of functionalized single walled carbon nanotubes enhance ex vivo expansion of hematopoietic stem and progenitor cells in human umbilical cord blood. Nanomedicine: Nanotechnology, Biology and Medicine 9 (8), 1304-1316. (2013)
Ghosh, A.; Saginc, G.; Leow, S. C.; Khattar, E.; Shin, E. M.; Yan, T. D.; Wong, M.; Zhang, Z.; Li, G.; Sung, W.-K.; Zhou, J.; Chng, W. J.; Li S.; Liu, E.; Tergaonkar, V., Telomerase directly regulates NF-κB-dependent transcription. Nature Cell Biology 14 (12), 1270-1281. (2012)
Li S.., Cell-cycle-dependent telomere elongation by telomerase in budding yeast. Bioscience Reports 2011, 31 (3), 169-177. (2011)
Li S.; Makovets, S.; Matsuguchi, T.; Blethrow, J. D.; Shokat, K. M.; Blackburn, E. H., Cdk1-Dependent Phosphorylation of Cdc13 Coordinates Telomere Elongation during Cell-Cycle Progression. Cell, 136 (1), 50-61. (2009)
Li S.; Nosrati, M.; Kashani-Sabet, M., Knockdown of Telomerase RNA Using Hammerhead Ribozymes and RNA Interference. In Telomerase Inhibition: Strategies and Protocols, Andrews, L. G.; Tollefsbol, T. O., Eds. Humana Press: Totowa, NJ, pp 113-131. (2007)
Bagheri, S.; Nosrati, M.; Li S.; Fong, S.; Torabian, S.; Rangel, J.; Moore, D. H.; Federman, S.; Laposa, R. R.; Baehner, F. L.; Sagebiel, R. W.; Cleaver, J. E.; Haqq, C.; Debs, R. J.; Blackburn, E. H.; Kashani-Sabet, M., Genes and pathways downstream of telomerase in melanoma metastasis. Proceedings of the National Academy of Sciences of the United States of America 103 (30), 11306-11311. (2006)
Li S.; Crothers, J.; Haqq, C. M.; Blackburn, E. H., Cellular and Gene Expression Responses Involved in the Rapid Growth Inhibition of Human Cancer Cells by RNA Interference-mediated Depletion of Telomerase RNA. Journal of Biological Chemistry 280 (25), 23709-23717. (2005)
Nosrati, M.; Li S.; Bagheri, S.; Ginzinger, D.; Blackburn, E. H.; Debs, R. J.; Kashani-Sabet, M., Antitumor Activity of Systemically Delivered Ribozymes Targeting Murine Telomerase RNA. Clinical Cancer Research 10 (15), 4983. (2004)
Li S.; Rosenberg, J. E.; Donjacour, A. A.; Botchkina, I. L.; Hom, Y. K.; Cunha, G. R.; Blackburn, E. H., Rapid Inhibition of Cancer Cell Growth Induced by Lentiviral Delivery and Expression of Mutant-Template Telomerase RNA and Anti-telomerase Short-Interfering RNA. Cancer Research 64 (14), 4833. (2004)
Zheng, L.; Pan, H.; Li S.; Flesken-Nikitin, A.; Chen, P.-L.; Boyer, T. G.; Lee, W.-H., Sequence-Specific Transcriptional Corepressor Function for BRCA1 through a Novel Zinc Finger Protein, ZBRK1. Molecular Cell 6 (4), 757-768. (2000)
Li S.; Ting, N. S. Y.; Zheng, L.; Chen, P.-L.; Ziv, Y.; Shiloh, Y.; Lee, E. Y. H. P.; Lee, W.-H., Functional link of BRCA1 and ataxia telangiectasia gene product in DNA damage response. Nature 406 (6792), 210-215. (2000)