Research Interests: Dr Yeo's current research focus is on the multi-dimensional interrogation of childhood onset Systemic Lupus Erythematosus Immunome using mass cytometry with the dual translational goals of identifying predictors of clinical fate and novel therapeutic targets for manipulation.
Additionally, to catalyse the pace of translational research, Dr Yeo and his research team have characterised the healthy Immunome (peripheral blood mononuclear cells) from birth to the elderly using mass cytometry. This database will serve as a reference standard for others to compare their results against and will be deployed as an online resource (Extended Poly-dimensional Immunome Characterisation, EPIC). The web-based EPIC platform is developed and hosted by Translational Immunology Institute, SingHealth Duke-NUS Academic Medical Centre.
Publications:
Wong JJM, Leong JY, Lee JH, Albani S, Yeo JG. Insights into the immuno-pathogenesis of acute respiratory distress syndrome. Annals of translational medicine. 2019;7(19):504.
Wong JJ, Jit M, Sultana R, Mok YH, Yeo JG, Koh J, Loh TF, Lee JH. Mortality in Pediatric Acute Respiratory Distress Syndrome: A Systematic Review and Meta-Analysis. Journal of intensive care medicine. 2019;34(7):563-71.
Wienke J, Bellutti Enders F, Lim J, Mertens JS, van den Hoogen LL, Wijngaarde CA, Yeo JG, Meyer A, Otten HG, Fritsch-Stork RDE, Kamphuis SSM, Hoppenreijs E, Armbrust W, van den Berg JM, Hissink Muller PCE, Tekstra J, Hoogendijk JE, Deakin CT, de Jager W, van Roon JAG, van der Pol WL, Nistala K, Pilkington C, de Visser M, Arkachaisri T, Radstake T, van der Kooi AJ, Nierkens S, Wedderburn LR, van Royen-Kerkhof A, van Wijk F. Galectin-9 and CXCL10 as Biomarkers for Disease Activity in Juvenile Dermatomyositis: A Longitudinal Cohort Study and Multicohort Validation. Arthritis & rheumatology (Hoboken, NJ). 2019;71(8):1377-90.
Tay SH, Yaung KN, Leong JY, Yeo JG, Arkachaisri T, Albani S. Immunomics in Pediatric Rheumatic Diseases. Frontiers in medicine. 2019;6:111.
Leong JY, Chen P, Yeo JG, Ally F, Chua C, Nur Hazirah S, Poh SL, Pan L, Lai L, Lee ESC, Bathi LDT, Arkachaisri T, Lovell D, Albani S. Immunome perturbation is present in patients with juvenile idiopathic arthritis who are in remission and will relapse upon anti-TNFalpha withdrawal. Annals of the rheumatic diseases. 2019;78(12):1712-21.
Kumar P, Shih DCW, Lim A, Paleja B, Ling S, Li Yun L, Li Poh S, Ngoh A, Arkachaisri T, Yeo JG, Albani S. Pro-inflammatory, IL-17 pathways dominate the architecture of the immunome in pediatric refractory epilepsy. JCI insight. 2019;5.
Leong JY, Yeo JG, Albani S, Arkachaisri T. Recent advances in our understanding of the pathogenesis of juvenile idiopathic arthritis and their potential clinical implications. Expert review of clinical immunology. 2018;14(11):933-44.
Ganapathy S, Yeo JG, Thia XHM, Hei GMA, Tham LP. The Singapore Paediatric Triage Scale Validation Study. Singapore medical journal. 2018;59(4):205-9.
Chong SL, Lai OF, Castillo L, Yeo JG, Nadkarni N, Teoh OH, Lee JH. Nasal high-mobility group box 1 and caspase in bronchiolitis. Pediatric pulmonology. 2018;53(12):1627-32.
Yeo JG, Ng CT, Albani S. Precision medicine in pediatric rheumatology. Current opinion in rheumatology. 2017;29(5):500-5.
Lai L, Yeo JG, Albani S. Singlet gating in mass cytometry. Cytometry Part A : the journal of the International Society for Analytical Cytology. 2017;91(2):170-2.
Chong SL, Teoh OH, Nadkarni N, Yeo JG, Lwin Z, Ong YG, Lee JH. The modified respiratory index score (RIS) guides resource allocation in acute bronchiolitis. Pediatric pulmonology. 2017;52(7):954-61.
Yeo JG, Leong J, Lu J. Complement the cell death. Cell death & disease. 2016;7(11):e2465.
Yeo JG, Leong J, Arkachaisri T, Cai Y, Teo BH, Tan JH, Das L, Lu J. Proteolytic inactivation of nuclear alarmin high-mobility group box 1 by complement protease C1s during apoptosis. Cell death discovery. 2016;2:16069.
Cai Y, Teo BH, Yeo JG, Lu J. C1q protein binds to the apoptotic nucleolus and causes C1 protease degradation of nucleolar proteins. The Journal of biological chemistry. 2015;290(37):22570-80.
Wong JJ, Loh TF, Testoni D, Yeo JG, Mok YH, Lee JH. Epidemiology of pediatric acute respiratory distress syndrome in Singapore: risk factors and predictive respiratory indices for mortality. Frontiers in pediatrics. 2014;2:78.
Teh BK, Yeo JG, Chern LM, Lu J. C1q regulation of dendritic cell development from monocytes with distinct cytokine production and T cell stimulation. Molecular immunology. 2011;48(9-10):1128-38.
Goh A, Chong CY, Tee N, Loo LH, Yeo JG, Chan YH. Pertussis--an under-diagnosed disease with high morbidity in Singapore children. Vaccine. 2011;29(13):2503-7.