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Ecosse Lamoureux

Professor

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Bio Research Publications

Professor Ecosse Lamoureux holds a tenured appointment with the Duke-NUS Medical School (Health Services and System Research Department) and professorial appointments with the National University of Singapore and the University of Melbourne. He is the Director of the Population Health and Clinical Epidemiology Platform at the Singapore Eye Research Institute (SERI).

His research programme focuses on sensory impairment in the elderly; and the prevention, intervention, and outcomes research associated with eye diseases; aging; and diabetes microvascular complications. His research includes the implementation of novel RCTs; population-based epidemiological studies; new prevention and treatment models for vision impairment and eye care; adherence to management of eye diseases; and patient-centred outcomes. Importantly, his work has produced novel computer adaptive testing systems (a form of AI  technology) to optimally assess the impact of eye diseases and associated treatment efficacies.

To date, his overall research activities have attracted over SG$40 million in competitive grant funding in Australia (Australian NHMRC, Australian ARC) and Singapore (Singapore NMRC). In addition, he has been awarded numerous fellowships such as the Australian NHMRC Career Fellowships, and the Singapore Clinician Scientist Award. He has over 400 publications in top international journals, and his international standing is supported by numerous invited oral presentations at international and regional conferences.

Research Interest

Professor Lamoureux is recognized locally and internationally for his research in population health; epidemiology; patient-centred outcomes; development of patient-reported outcome measures using modern psychometric theory, item banking, and computer adaptive testing; and quality of life outcomes in the elderly and underprivileged community groups. His current population-based and epidemiological cohort is a contemporary patient-centric study of the old and very old elderly individuals in Singapore with a specific focus on sensory impairment, sarcopenia, osteoporosis, frailty (physical and cognitive) and multimorbidity. He is also currently developing several item banks and computer adaptive testing systems for major eye conditions and diabetes. 

Research Team

Zeena Akhbar
Administrative Specialist (PA to Prof Ecosse)
zeena.akhbar@duke-nus.edu.sg

  1. Finger, R., Fenwick, E.K., Holz, F., Pesudovs, K., Lamoureux, E.L Rasch analysis reveals problems with multiplicative scoring in the MacDQoL. Ophthalmology 2012. 119(11):2351-7.
  2. Noonan JE, Jenkins AJ, Ma JX, Keech AC, Wang JJ, Lamoureux, E.L. An update on the molecular actions of fenofibrate and its clinical effects on diabetic retinopathy and other microvascular end points in patients with diabetes. Diabetes. 2013. Dec;62(12):3968-75.
  3. Nguyen HV, Tan GS, Tapp RJ, Mital S, Ting DS, Wong HT, Tan CS, Laude A, Tai ES, Tan NC, Finkelstein EA, Wong TY, Lamoureux, E.L. Cost-effectiveness of a National Telemedicine Diabetic Retinopathy Screening Program in Singapore. Ophthalmology. 2016 Dec;123(12):2571-2580.
  4. G Rees, J Xie, EK. Fenwick, BA Sturrock, R Finger, SL Rogers, L Lim, Lamoureux, E.L. Association Between Diabetes-Related Eye Complications and Symptoms of Anxiety and Depression. JAMA Ophthalmology. 2016 Sep 1;134(9):1007-14.
  5. Lamoureux, E.L,Taylor H, Wong TY.  Frequency of Evidence-Based Screening for Diabetic Retinopathy. N Engl J Med. 2017. Jul;13;377(2):194-195.
  6. Ting DSW, Cheung CY, Lim G, Tan GSW, Quang ND, Gan A, Hamzah H, Garcia-Franco R, San Yeo IY, Lee SY, Wong EYM, Sabanayagam C, Baskaran M, Ibrahim F, Tan NC, Finkelstein EA, Lamoureux, E.L., Wong IY, Bressler NM, Sivaprasad S, Varma R, Jonas JB, He MG, Cheng CY, Cheung GCM, Aung T, Hsu W, Lee ML, Wong TY.  Development and Validation of a Deep Learning System for Diabetic Retinopathy and Related Eye Diseases Using Retinal Images From Multiethnic Populations With Diabetes.JAMA 2017. Dec;12;318(22):2211-2223.
  7. Man REK, Fenwick EK, Gan ATL, Sabanayagam C, Gupta P, Aravindhan A, Wong TY, Tan GSW, Lamoureux, E.L. Association Between Perceived Barriers to Diabetes Self-management and Diabetic Retinopathy in Asian Patients With Type 2 Diabetes.  JAMA Ophthalmol. 2017. Dec 1;135(12):1387-1393.
  8. Gupta P, Liang Gan AT, Kidd Man RE, Fenwick EK, Kumari N, Tan G, Mitchell P, Sabanayagam C, Wong TY, Cheng CY, Lamoureux, E.L. Impact of Incidence and Progression of Diabetic Retinopathy on Vision-Specific Functioning. Ophthalmology. 2018 Sep;125(9):1401-1409.
  9. Sabanayagam C, Banu R, Chee ML, Lee R, Wang YX, Tan G, Jonas JB, Lamoureux, E.L., Cheng CY, Klein BEK, Mitchell P, Klein R, Cheung CMG, Wong TY. Incidence and progression of diabetic retinopathy: a systematic review. Lancet Diabetes Endocrinol. 2019 Feb;7(2):140-149.
  10. Man RE, Gan AT, Gupta P, Fenwick EK, Sabanayagam C, Tan NY, Mitchell P, Wong TY, Cheng CY, Lamoureux, E.L.  Is Myopia associated with the Incidence and Progression of Diabetic Retinopathy?  Am J Ophthalmol. 2019 Dec;208:226-233.