Duke-NUS Medical School

Directory

Ooi Yaw Shin

Assistant Professor, Signature Research Programme in Emerging Infectious Diseases

yawshin.ooi@duke-nus.edu.sg

About

Publications

Bio

Yaw Shin is an Assistant Professor in the Emerging Infectious Diseases (EID) program at Duke-NUS Medical School. He received his doctorate from Albert Einstein College of Medicine (Mentor: Margaret Kielian), New York, and later pursued his postdoctoral training at Stanford University (Mentor: Jan Carette), California. He has a long-established interest in discovering cellular factors (host dependency factors and restrictions factors) that determine susceptibility and permissivity to virus infections. Host dependency factors are keys hijacked by viruses to penetrate cellular barriers and rewire host cells for promoting viral protein translation, genome replication, assembly, exit, and spread. In contrast, viruses must evade antiviral innate immunity to avoid tolls during the infection process, especially by antagonizing host restriction factors. Currently, his team's focus is centered on mosquito-borne RNA viruses and human respiratory RNA viruses – all pose serious threats to global public health.

For more information, please visit our lab website.

Education

Doctor of Philosophy

Yeshiva University, United States

Master of Science

Yeshiva University, United States

Master of Science

University of Malaya, Malaysia

BSc (Genet & Molecular Bio) Hons w Dist

University of Malaya, Malaysia

Directory

Bio

Education

Doctor of Philosophy

Master of Science

Master of Science

BSc (Genet & Molecular Bio) Hons w Dist

Publications

Know your enemy and know yourself - the case of SARS-CoV-2 host factors.

A memory of eS25 loss drives resistance phenotypes.

Enterovirus Pathogenesis Requires the Host Methyltransferase SETD3.

An RNA-Centric Dissection of Host Complexes Controlling Flavivirus Infection.

Mechanism of Tetherin Inhibition of Alphavirus Release.

SETD3 is an actin histidine methyltransferase that prevents primary dystocia.

STAG2 deficiency induces IFN responses via cGAS-STING pathway and restricts virus infection.

A small molecule oligosaccharyltransferase inhibitor with pan-flaviviral activity.

Drebrin restricts rotavirus entry by inhibiting dynamin-mediated endocytosis.

A CRISPR toolbox to study virus-host interactions.

Genetic dissection of Flaviviridae host factors through genome-scale CRISPR screens.

BST2/Tetherin inhibits alphavirus exit.

Genome-wide RNAi screen identifies novel host proteins required for alphavirus entry.

Directory

Bio

Education

Doctor of Philosophy

Master of Science

Master of Science

BSc (Genet & Molecular Bio) Hons w Dist

Publications

Know your enemy and know yourself - the case of SARS-CoV-2 host factors.

A memory of eS25 loss drives resistance phenotypes.

Enterovirus Pathogenesis Requires the Host Methyltransferase SETD3.

An RNA-Centric Dissection of Host Complexes Controlling Flavivirus Infection.

Mechanism of Tetherin Inhibition of Alphavirus Release.

SETD3 is an actin histidine methyltransferase that prevents primary dystocia.

STAG2 deficiency induces IFN responses via cGAS-STING pathway and restricts virus infection.

A small molecule oligosaccharyltransferase inhibitor with pan-flaviviral activity.

Drebrin restricts rotavirus entry by inhibiting dynamin-mediated endocytosis.

A CRISPR toolbox to study virus-host interactions.

Genetic dissection of Flaviviridae host factors through genome-scale CRISPR screens.

BST2/Tetherin inhibits alphavirus exit.

Genome-wide RNAi screen identifies novel host proteins required for alphavirus entry.

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