MEDICUS A Moment with Issue 3 2024 2
Credit: Norfaezah Abdullah, Duke-NUS

 


Weaving new hope in reproductive medicine

 By Dr Ku Chee Wai (MD Class of 2013 and PhD Class of 2024, Duke-NUS); Consultant, Department of Reproductive Medicine, KK Women's and Children's Hospital
 

It all started in 2010, when I was a second-year medical student at Duke-NUS. During my Obstetrics and Gynaecology posting, I saw patients suffer from bleeding in the early stages of their pregnancy. It affected me very much because there was no effective screening tool to prognosticate the outcome of threatened miscarriage, which presents as vaginal bleeding in early pregnancy and affects up to 25 per cent of all pregnancies. Around 15 per cent to 20 per cent of threatened miscarriages progress to miscarriage, but almost every couple suffers an emotional rollercoaster from not knowing what the outcome may be.  

I felt that I had to do something more to help. Research was one way in which I could explore new ways of managing such conditions to reduce the fear and uncertainties that expectant mothers face.  

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Thus, I embarked on a research project in my third year of medical school. After looking at several options, my team and I decided to work on a biochemical marker called serum progesterone. Doing a blood test for the levels of the progesterone hormone in the body allowed us to differentiate between women who had low-risk or high-risk pregnancies. This protocol was implemented in KK Women’s and Children’s Hospital (KKH), so that doctors can better tailor treatment for patients with threatened miscarriage.  


After I graduated from medical school, I was focused on pursuing my clinical training but all along, I still wanted to work on research to come up with innovative solutions to improve women’s and children’s health. So in 2020, I took up a PhD in Clinical and Translational Sciences, also at Duke-NUS. This allowed me to continue my research efforts in the field of Reproductive Medicine.

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Dr Ku Chee Wai's passion for improving women's and children's health prompted him to pursue a PhD in Clinical and Translational Medicine at Duke-NUS in 2020 // Credit: Norfaezah Abdullah, Duke-NUS 

Obstetrics and Gynaecology have always been special for me. To me, it is “happy medicine”—a rare specialty where I can congratulate patients on the arrival of a new life and see the smiles on their faces when they find out whether it’s a girl or a boy.  

I wanted to see more such smiles. So for my next project, I worked on a new lifestyle intervention tool to help women with overweight or obesity issues assess and guide their eating behaviour before, during and after pregnancy. Called 6P, the tool breaks nutrition and physical activity into six components: portion, proportion, pleasure, phase, physicality and psychology.  

We implemented the tool in a study where participants answered questions related to these components, e.g., diet and physical activity, on a digital platform, which then generated recommendations on healthy eating. More than 80 per cent of the study participants agreed that the 6P tool was useful in guiding them towards a healthier diet.  

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Using digital platforms to improve pregnancy care // Credit: Norfaezah Abdullah, Duke-NUS 

Building on this work, the 6P tool was rolled out in a single-arm implementation trial called “Healthy Early Life Moments in Singapore (HELMS)”. This is a digital intervention, featuring educational modules from preconception to pregnancy and postpartum periods. The app provides advice and guides goal-setting on lifestyle behaviours that include diet, physical activity, mental wellness and sleep hygiene. It aims to help women with overweight or obesity issues improve their metabolic and mental health before, during and after pregnancy, as well as improve their baby’s growth in his/her early stages of life. 

We received positive feedback for the project and launched the web application in 2022. A year later, it became available on the Health Buddy mobile application, and provides access to health information and services. 

With the preconception phase completed, we will continue our follow-up for those who are pregnant and those who have delivered their baby. This will take another two to three years as we evaluate the efficacy of this intervention.   

What I have observed, in the meantime, is encouraging though. I follow-up with every study participant during their study visits until they deliver. It is heartening when they tell me that they’ve made a positive change to their lifestyle after joining the programme. For example, many have switched from full-sugar options to no-sugar options when buying their favourite drink.   


Satisfying as it may be, such research projects require substantial commitment. A typical day in my life involves starting work as a clinician at 7am. I end my clinical work at around 6pm and head home to spend time with my wife, two children, aged 3 years and 8 months respective, and my dog! (That’s if I’m not on call or get called back for a delivery.) Most days of the week, I then start my research meetings or research work around 9.30pm and sometimes, those meetings or my research work can continue till later. 

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Building a strong foundation for healthy women // Credit: Norfaezah Abdullah, Duke-NUS 

What keeps me going is knowing that by improving the health of the mother, the child's health will be optimised too. If we can improve the health of the mother, we can break the vicious cycle of ill-health and improve the health of her baby. I will continue with my research efforts and I am grateful to my family, the Department of Reproductive Medicine in KKH, as well as the HELMS team, who have all played a huge part in building a strong foundation for healthy women and secure a better start for future generations.  

As told to Alice Chia, Senior media and content specialist. 

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