Research Track Faculty Staff Details

My research is focused on the development and validation of molecular tools that objectively measure drug and vaccine safety and efficacy. Applying these molecular tools in various clinical studies provides an evidence-based approach to define molecular endpoints that allow rapid selection of promising vaccine and therapeutic candidates for further clinical development.. Molecular correlates for viral infection outcomes

Viral infection leads to a wide spectrum of infection outcomes, ranging from asymptomatic infections to fatal complications like internal bleeding or organ damage. We aim to characterize the host responses associated with poor or good outcomes by assessing the host response over multiple time points.

2. Multi-omic profiling of host response to assess safety and effectiveness of new vaccine and therapeutic candidates

To complement existing clinical trial endpoints for safety and efficacy, we utilize multi-omic profiling of the host response early post-intervention to monitor safety of new drugs and vaccines, as well as to define the molecular determinants of vaccine immunogenicity and pharmacodynamics of antiviral therapeutics.

Adverse effects following anti-COVID-19 vaccination with mRNA-based BNT162b2 are alleviated by altering the route of administration and correlate with baseline enrichment of T and NK cell genes.

PLoS biology – Syenina Ayesa; Gan Esther S; Toh Justin Z N; de Alwis Ruklanthi; Lin Lowell Z; Tham Christine Y L; Yee Jia Xin; Leong Yan Shan; Sam Huizhen; Cheong Charlene; Teh Yii Ean; Wee Ian L E; Ng Dorothy H L; Chan Kuan Rong; Sim Jean X Y; Kalimuddin Shirin; Ong Eugenia Z; Low Jenny G; Ooi Eng Eong (2022)

20 (5);

Early T cell and binding antibody responses are associated with COVID-19 RNA vaccine efficacy onset.

Med (New York, N.Y.) – Kalimuddin Shirin; Tham Christine Y L; Qui Martin; de Alwis Ruklanthi; Sim Jean X Y; Lim Joey M E; Tan Hwee-Cheng; Syenina Ayesa; Zhang Summer L; Le Bert Nina; Tan Anthony T; Leong Yan Shan; Yee Jia Xin; Ong Eugenia Z; Ooi Eng Eong; Bertoletti Antonio; Low Jenny G (2021)

2 (6); 682-688.e4

Temporal dynamics of the host molecular responses underlying severe COVID-19 progression and disease resolution.

EBioMedicine – Ong Eugenia Z; Kalimuddin Shirin; Chia Wen Chong; Ooi Sarah H; Koh Clara Wt; Tan Hwee Cheng; Zhang Summer L; Low Jenny G; Ooi Eng Eong; Chan Kuan Rong (2021)

65

A Dynamic Immune Response Shapes COVID-19 Progression.

Cell host & microbe – Ong Eugenia Ziying; Chan Yvonne Fu Zi; Leong Wan Ying; Lee Natalie Mei Ying; Kalimuddin Shirin; Haja Mohideen Salahudeen Mohamed; Chan Kian Sing; Tan Anthony Tanoto; Bertoletti Antonio; Ooi Eng Eong; Low Jenny Guek Hong (2020)

27 (6); 879-882.e2

Metabolic perturbations and cellular stress underpin susceptibility to symptomatic live-attenuated yellow fever infection.

Nature medicine – Chan Kuan Rong; Gan Esther Shuyi; Chan Candice Yuen Yue; Liang Cui; Low John Zhong Heng; Zhang Summer Li-Xin; Ong Eugenia Ziying; Bhatta Ashwin; Wijaya Limin; Lee Yie Hou; Low Jenny Guek-Hong; Ooi Eng Eong (2019)

25 (8); 1218-1224

Genomic signature of early T-cell response is associated with lower antibody titer threshold for sterilizing immunity.

Antiviral research – Ong Eugenia Z; Gan Esther S; de Alwis Ruklanthi; Wijaya Limin; Ong Xin Mei; Zhang Menglan; Wong Abigail Wl; Cheung Yin Bun; Zellweger Raphaël M; Ooi Eng Eong; Low Jenny G (2019)

166 35-41

Preclinical evaluation of VIS513, a therapeutic antibody against dengue virus, in non-human primates.

Antiviral research – Ong Eugenia Z; Budigi Yadunanda; Tan Hwee Cheng; Robinson Luke N; Rowley Kirk J; Winnett Alexander; Hobbie Sven; Shriver Zachary; Babcock Gregory J; Ooi Eng Eong (2017)

144 44-47

Dengue subgenomic RNA binds TRIM25 to inhibit interferon expression for epidemiological fitness.

Science (New York, N.Y.) – Manokaran Gayathri; Finol Esteban; Wang Chunling; Gunaratne Jayantha; Bahl Justin; Ong Eugenia Z; Tan Hwee Cheng; Sessions October M; Ward Alex M; Gubler Duane J; Harris Eva; Garcia-Blanco Mariano A; Ooi Eng Eong (2015)

350 (6257); 217-21

Leukocyte immunoglobulin-like receptor B1 is critical for antibody-dependent dengue.

Proceedings of the National Academy of Sciences of the United States of America – Chan Kuan Rong; Ong Eugenia Z; Tan Hwee Cheng; Zhang Summer Li-Xin; Zhang Qian; Tang Kin Fai; Kaliaperumal Nivashini; Lim Angeline Pei Chiew; Hibberd Martin L; Chan Soh Ha; Connolly John E; Krishnan Manoj N; Lok Shee Mei; Hanson Brendon J; Lin Chao-Nan; Ooi Eng Eong (2014)

111 (7); 2722-7