Tan Anthony Tanoto received his PhD degree from the National University of Singapore, studying the immunopathogenesis of HBV and characterising the innate and adaptive immune responses in different groups of HBV infected patients. He then joined the Singapore Institute for Clinical Sciences (Agency for Science, Technology and Research, A*STAR) as a postdoctoral fellow, before moving DUKE-NUS Medical school, to continue his research career in HBV immunopathogenesis and treatment of HBV-related liver cancer. He is currently an Assistant Professor in the Emerging Infectious Diseases Programme in DUKE-NUS Medical School.
His research is centred on the study of virus-specific T cell responses in humans, with a primary interest on Hepatitis B virus infection, and the development of T cell immunotherapy for HBV-related liver cancer. He has worked closely with industry and healthcare partners to translate the novel T cell immunotherapy approaches into the clinics. During the COVID-19 pandemic, he has also contributed significantly to the understanding of virus-specific T cell responses in SARS-CoV-2 infection with notable publications in high-impact journals. In addition, he has received funding from the Programme for Research in Epidemic Preparedness and Response and the National Health Innovation Centre to study the T cell responses against other viruses of interest in an effort to use virus-specific T cell response information in addressing clinical questions.
My research focus has always been on virus-specific T cells and TCR T cell immunotherapy. For the former, I am particularly interested in how the characterisation of virus-specific T cells in different diseases could be used to better manage clinical decisions.
On the TCR T cell immunotherapy front, I am further developing the approach to improve accessibility, safety and efficacy in different groups of patients persistently infected with HBV (chronic HBV infected; patients with primary HBV-related hepatocellular carcinoma; patients with HBV-related hepatocellular carcinoma recurrence after liver transplantation) and working with industry and healthcare partners to translate the approach into patients.
Bertoletti Antonio; Le Bert Nina;Tan Anthony T. SARS-CoV-2-specific T cells in the changing landscape of the COVID-19 pandemic. Immunity 2022; 55(10):1764-1778.
Lim Joey Ming Er; Hang Shou Kit; Hariharaputran Smrithi; Chia Adeline; Tan Nicole; Lee Eng Sing; Chng Edwin; Lim Poh Lian; Young Barnaby E; Lye David Chien; Le Bert Nina; Bertoletti Antonio;Tan Anthony T. A comparative characterization of SARS-CoV-2-specific T cells induced by mRNA or inactive virus COVID-19 vaccines. Cell reports. Medicine 2022; 3(11):100793-N.A.
Tan Anthony Tanoto; Meng Fanping; Jin Jiehua; Zhang Ji-Yuan; Wang Si-Yu; Shi Lei; Shi Ming; Li Yuanyuan; Xie Yunbo; Liu Li-Min; Zhou Chun-Bao; Chua Alicia; Ho Zi Zong; Luan Junqing; Zhao Jinfang; Li Jing; Wai Lu-En; Koh Sarene; Wang Tingting; Bertoletti Antonio; Wang Fu-Sheng. Immunological alterations after immunotherapy with short lived HBV-TCR T cells associates with long-term treatment response in HBV-HCC. Hepatology communications 2022; 6(4):841-854.
Schwarz Megan; Torre Denis; Lozano-Ojalvo Daniel;Tan Anthony T; Tabaglio Tommaso; Mzoughi Slim; Sanchez-Tarjuelo Rodrigo; Le Bert Nina; Lim Joey Ming Er; Hatem Sandra; Tuballes Kevin; Camara Carmen; Lopez-Granados Eduardo; Paz-Artal Estela; Correa-Rocha Rafael; Ortiz Alberto; Lopez-Hoyos Marcos; Portoles Jose; Cervera Isabel; Gonzalez-Perez Maria; Bodega-Mayor Irene; Conde Patricia; Oteo-Iglesias Jesús; Borobia Alberto M; Carcas Antonio J; Frías Jesús; Belda-Iniesta Cristóbal; Ho Jessica S Y; Nunez Kemuel; Hekmaty Saboor; Mohammed Kevin; Marsiglia William M; Carreño Juan Manuel; Dar Arvin C; Berin Cecilia; Nicoletti Giuseppe; Della Noce Isabella; Colombo Lorenzo; Lapucci Cristina; Santoro Graziano; Ferrari Maurizio; Nie Kai; Patel Manishkumar; Barcessat Vanessa; Gnjatic Sacha; Harris Jocelyn; Sebra Robert; Merad Miriam; Krammer Florian; Kim-Schulze Seunghee; Marazzi Ivan; Bertoletti Antonio; Ochando Jordi; Guccione Ernesto. Rapid, scalable assessment of SARS-CoV-2 cellular immunity by whole-blood PCR. Nature biotechnology 2022; 40(11):1680-1689.
Swadling Leo; Diniz Mariana O; Schmidt Nathalie M; Amin Oliver E; Chandran Aneesh; Shaw Emily; Pade Corinna; Gibbons Joseph M; Le Bert Nina;Tan Anthony T; Jeffery-Smith Anna; Tan Cedric C S; Tham Christine Y L; Kucykowicz Stephanie; Aidoo-Micah Gloryanne; Rosenheim Joshua; Davies Jessica; Johnson Marina; Jensen Melanie P; Joy George; McCoy Laura E; Valdes Ana M; Chain Benjamin M; Goldblatt David; Altmann Daniel M; Boyton Rosemary J; Manisty Charlotte; Treibel Thomas A; Moon James C; ; van Dorp Lucy; Balloux Francois; McKnight Áine; Noursadeghi Mahdad; Bertoletti Antonio; Maini Mala K. Pre-existing polymerase-specific T cells expand in abortive seronegative SARS-CoV-2. Nature 2022; 601(7891):110-117.
Tan Anthony T; Linster Martin; Tan Chee Wah; Le Bert Nina; Chia Wan Ni; Kunasegaran Kamini; Zhuang Yan; Tham Christine Y L; Chia Adeline; Smith Gavin J D; Young Barnaby; Kalimuddin Shirin; Low Jenny G H; Lye David; Wang Lin-Fa; Bertoletti Antonio. Early induction of functional SARS-CoV-2-specific T cells associates with rapid viral clearance and mild disease in COVID-19 patients. Cell reports 2021; 34(6):108728-N.A.
Tan Anthony T; Lim Joey Me; Le Bert Nina; Kunasegaran Kamini; Chia Adeline; Qui Martin Dc; Tan Nicole; Chia Wan Ni; de Alwis Ruklanthi; Ying Ding; Sim Jean Xy; Ooi Eng Eong; Wang Lin-Fa; Chen Mark I-Cheng; Young Barnaby E; Hsu Li Yang; Low Jenny Gh; Lye David C; Bertoletti Antonio. Rapid measurement of SARS-CoV-2 spike T cells in whole blood from vaccinated and naturally infected individuals. The Journal of clinical investigation 2021; 131(17).
Le Bert Nina; Clapham Hannah E; Tan Anthony T; Chia Wan Ni; Tham Christine Y L; Lim Jane M; Kunasegaran Kamini; Tan Linda Wei Lin; Dutertre Charles-Antoine; Shankar Nivedita; Lim Joey M E; Sun Louisa Jin; Zahari Marina; Tun Zaw Myo; Kumar Vishakha; Lim Beng Lee; Lim Siew Hoon; Chia Adeline; Tan Yee-Joo; Tambyah Paul Anantharajah; Kalimuddin Shirin; Lye David; Low Jenny G H; Wang Lin-Fa; Wan Wei Yee; Hsu Li Yang; Bertoletti Antonio; Tam Clarence C. Highly functional virus-specific cellular immune response in asymptomatic SARS-CoV-2 infection. The Journal of experimental medicine 2021; 218(5).
Hafezi Morteza; Lin Meiyin; Chia Adeline; Chua Alicia; Ho Zi Zong; Fam Royce; Tan Damien; Aw Joey; Pavesi Andrea; Krishnamoorthy Thinesh Lee; Chow Wan Cheng; Chen Wenjie; Zhang Qi; Wai Lu-En; Koh Sarene;Tan Anthony T; Bertoletti Antonio. Immunosuppressive Drug-Resistant Armored T-Cell Receptor T Cells for Immune Therapy of HCC in Liver Transplant Patients. Hepatology (Baltimore, Md.) 2021; 74(1):200-213.
Le Bert Nina;Tan Anthony T; Kunasegaran Kamini; Tham Christine Y L; Hafezi Morteza; Chia Adeline; Chng Melissa Hui Yen; Lin Meiyin; Tan Nicole; Linster Martin; Chia Wan Ni; Chen Mark I-Cheng; Wang Lin-Fa; Ooi Eng Eong; Kalimuddin Shirin; Tambyah Paul Anantharajah; Low Jenny Guek-Hong; Tan Yee-Joo; Bertoletti Antonio. SARS-CoV-2-specific T cell immunity in cases of COVID-19 and SARS, and uninfected controls. Nature 2020; 584(7821):457-462.
Tan Anthony Tanoto; Yang Ninghan; Lee Krishnamoorthy Thinesh; Oei Vincent; Chua Alicia; Zhao Xinyuan; Tan Hui Si; Chia Adeline; Le Bert Nina; Low Diana; Tan Hiang Keat; Kumar Rajneesh; Irani Farah Gillan; Ho Zi Zong; Zhang Qi; Guccione Ernesto; Wai Lu-En; Koh Sarene; Hwang William; Chow Wan Cheng; Bertoletti Antonio. Use of Expression Profiles of HBV-DNA Integrated Into Genomes of Hepatocellular Carcinoma Cells to Select T Cells for Immunotherapy. Gastroenterology 2019; 156(6):1862-1876.e9.