Vasudevan Subhash

Professor

Email

Contact: 65166718

Bio Research Publications

Professor Vasudevan’s unique research and teaching career since 1989 also includes 5 years in a senior management position in a large Swiss pharmaceutical company. He has built an extensive academic network that serves as a significant professional asset and has published more than 150 peer-reviewed articles that have been cited more > 11000 times, with a H-index of 61. His professional interests include finding better health solutions through bench to bedside research, teaching innovations and public health initiatives to prevent infections. He founded Singapore Advanced Biologics Pte Ltd in 2011 and led Singapore’s first Phase 1b clinical trial to test an antiviral drug in dengue patients in 2013 that has been licensed from NUS.


 

1. Viral protein structure and function

2. Drug discovery and development for emerging infectious diseases

3. Animal models for flaviviral infection and therapeutics studies

A T164S mutation in the dengue virus NS1 protein is associated with greater disease severity in mice. Chan KWK, Watanabe S, Jin JY, Pompon J, Teng D, Alonso S, Vijaykrishna D, Halstead SB, Marzinek JK, Bond PJ, Burla B, Torta F, Wenk MR, Ooi EE, Vasudevan SG. Sci Transl Med. 2019 Jun 26;11(498). pii: eaat7726. doi: 10.1126/scitranslmed.aat7726. 

Chacko AM, Watanabe S, Herr KH, Kalimuddin S, Tham JY, Ong J, Reolo M, Serrano R, Cheung YB, Low JG and Vasudevan SG (2017) 18F-FDG as an Inflammation Biomarker for Imaging Dengue Virus Infection and Treatment. J Clin. Investigations Insight 4;2(9). pii: 93474.

Tay MY, Smith K, Ng IH, Chan KW, Zhao Y, Ooi EE, Lescar J, Luo D, Jans DA, Forwood JK, Vasudevan SG. (2016) The C-terminal 18 Amino Acid Region of Dengue Virus NS5 Regulates its Subcellular Localization and Contains a Conserved Arginine Residue Essential for Infectious Virus Production. PLoS Pathogens 12(9):e1005886.

Zhao, Y., Soh, T. S., Zheng, J., Chan, K. W. K., Phoo, W. W., Lee, C. C., Tay, M. Y. F., Swaminathan, K., Cornvik, T. C., Lim, S. P., Shi, P. Y., Lescar, J., Vasudevan, S. G., Luo, D. (2015). A crystal structure of the dengue virus NS5 protein reveals a novel inter-domain interface essential for protein flexibility and virus replication. PLoS Pathogens, 11(3), e1004682.

Zhao, Y., Soh, T. S., Chan, K. W. K., Fung, S. S. Y., Swaminathan, K., Lim, S. P., Shi, P-Y., Huber, T., Lescar, J., Luo, D., Vasudevan, SG (2015). Flexibility of NS5 Methyltransferase-Polymerase Linker Region Is Essential for Dengue Virus Replication. Journal of Virology, 89(20), 10717-10721.

Watanabe, S., Chan, K. W. K., Wang, J., Rivino, L., Lok, S. M., Vasudevan, SG (2015). Dengue Virus Infection with Highly Neutralizing Levels of Cross-Reactive Antibodies Causes Acute Lethal Small Intestinal Pathology without a High Level of Viremia in Mice. Journal of Virology, 89(11), 5847-5861.

Low, J. G., Sung, C., Wijaya, L., et al., Vasudevan, S. G. (2014). Efficacy and safety of celgosivir in patients with dengue fever (CELADEN): a phase 1b, randomised, double-blind, placebo-controlled, proof-of-concept trial. The Lancet Infectious Diseases, 14(8), 706-715.

Schul, W., Liu, W., Xu, H. Y., Flamand, M., Vasudevan, S. G. (2007). A dengue fever viremia model in mice shows reduction in viral replication and suppression of the inflammatory response after treatment with antiviral drugs. Journal of Infectious Diseases, 195(5), 665-674.

Fink, J., Gu, F., Ling, L., Tolfvenstam, T., Olfat, F., Chin, K. C., Aw, P., George, G., Kuznetsov, V. A., Schreiber, M., Vasudevan, S. G., Hibberd, M. L. (2007). Host gene expression profiling of dengue virus infection in cell lines and patients. PLoS Neglected Tropical Diseases, 1(2), e86.

Yap, T. L., Xu, T., Chen, Y. L., Malet, H., Egloff, M. P., Canard, B., Vasudevan, S. G., Lescar, J. (2007). Crystal structure of the dengue virus RNA-dependent RNA polymerase catalytic domain at 1.85-angstrom resolution. Journal of Virology, 81(9), 4753-4765.

Erbel, P., Schiering, N., D'Arcy, A., Renatus, M., Kroemer, M., Lim, S. P., Yin, Z., Keller, T. H., Vasudevan, S. G., Hommel, U. (2006). Structural basis for the activation of flaviviral NS3 proteases from dengue and West Nile virus. Nature Structural & Molecular Biology, 13(4), 372-373.