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Chemical Reprogramming: The path to next generation of regenerative medicine (On-site)
Abstract:
Chemical stimulation by exposure to small molecules offers a new approach that can manipulate cell fate in a simple and highly controllable manner. Life processes are in essence comprised of dynamic chemical processes, and the use of chemical small molecules to regulate cell fate is theoretically the most direct and effective method. Recently we demonstrated that small molecules can effectively reprogram human somatic cells to pluripotent stem cells (Nature, 2022; Cell Stem Cell, 2023). This approach provides a new platform for the generation and application of human pluripotent stem cells in biomedicine. In one such example, we established a protocol that generates functional pancreatic islet cells from hCiPSCs (Nat Med, 2022; Nat Metab, 2023). When transplanted, these hCiPSC-derived islets effectively ameliorated diabetes and restored endogenous insulin secretion in diabetic nonhuman primates. Our studies show the feasibility of transplanting hCiPSC-islets for diabetic treatment, marking a substantial step forward in clinical translation of hCiPSC-islets.
| Venue:
Level 2, Amphitheatre, Duke-NUS |
| Host:
Prof Zhang Suchun
Programme Director
Neuroscience & Behavioural Disorders Programme, Duke-NUS |
Contact Person:
Jacqueline Ho (jacqueline.ho@duke-nus.edu.sg)
Neuroscience & Behavioural Disorders Programme, Duke-NUS
|
Date and Time
18 Jul 2023 @ 12:00 - 18 Jul 2023 @ 13:00
Speaker
Prof Deng Hongkui
Boya Chair Professor
Senior Investigator of the Center for Life Sciences
Peking University, China
Hongkui Deng, is a Boya Chair Professor and Senior Investigator of the Center for Life Sciences at Peking University. He is also Department Chair of Cell Biology at School of Basic Medical Sciences of Peking University Health Science Center. Since 2013, he has been the director of the Peking University Stem Cell Research Center. Professor Deng’s research focuses on somatic cell reprogramming and lineage specific differentiation of human pluripotent stem cells. In 2013, his lab developed a chemical reprogramming strategy to induce pluripotent stem cells from somatic cell types using only small molecules. This breakthrough has opened new avenues for manipulating cellular states or identities via chemical reprogramming, and his lab has recently applied this chemical approach in promoting tissue regeneration in vivo.