Abstract:
Neurodegeneration, the progressive loss of nerve cells, is influenced by genetic mutations in RNA binding proteins (RBPs) and is conserved between fruit flies and humans. In our lab, we leverage fruit flies as a model organism to study RNA regulation in vivo. Specifically, we investigate how RBPs with IDR govern RNP assemblies. In my talk, I will discuss how structured and disordered domains in Ataxin-2 have opposing effects in RNP aggregation and cellular toxicity.
| Venue: | Room 7C, Level 7, Duke-NUS |
| Host: | Prof Wang Hongyan
Principal Investigator & Deputy Programme Director
Neuroscience & Behavioural Disorders Programme, Duke-NUS |
| Contact Person: | Joyceline Ng (joyceline.ng@duke-nus.edu.sg)
Neuroscience & Behavioural Disorders Programme, Duke-NUS |
All are welcome. No registration is required.
Date and Time
22 Jun 2023 @ 10:00 - 22 Jun 2023 @ 11:00
Speaker
Dr Baskar Bakthavachalu
DBT/Wellcome Trust India Alliance Intermediate Fellow
EMBO Global Investigator
Assistant Professor
School of Biosciences and Bioengineering
IIT Mandi, Himachal Pradesh
Dr Baskar Bakthavachalu holds the position of Assistant Professor at the Indian Institute of Technology Mandi, India. He is also recognized as an EMBO Global Investigator and a Wellcome-DBT India Alliance Intermediate fellow. Within his lab, Dr Bakthavachalu focuses on delving into the intricate cellular mechanisms underlying neurodegeneration, with a particular emphasis on RNA binding proteins, RNP granules, and the misregulation of translation.