Abstract:
Alzheimer's disease (AD) is the most common form of elderly dementia. Current research explores the gut-brain axis's roles in various neurological conditions, including autism, Parkinson's disease, and AD. Our lab found gut microbiome changes impact colon integrity, blood immune cells, brain conditions (amyloid plaques, tau tangles), and cognitive function in an AD animal model. We've developed technology to explore brain and gut organoids from control and AD patient iPSCs, potentially revealing initiators/regulators of the gut-brain pathway in AD.
Venue:
Meeting Room 7C, Level 7
Duke-NUS Medical School
Host:
Assoc Prof Hyunsoo Shawn Je
Principal Investigator
Neuroscience & Behavioural Disorders Programme, Duke-NUS
Contact Person:
Joyceline Ng (joyceline.ng@duke-nus.edu.sg)
Neuroscience & Behavioural Disorders Programme, Duke-NUS
Date and Time
02 Feb 2024 @ 00:00 - 02 Feb 2024 @ 00:00
Speaker
Prof Inhee Mook-Jung
Seoul National University College of Medicine
Director, National Dementia Research Center, Korea
Dr. Mook-Jung, Seoul National University College of Medicine, earned a B. Sc. in Molecular Biology (1986) from Seoul National University and a PhD in Neuroscience (1995) from the University of Arizona, USA. Specializing in Alzheimer’s disease (AD) pathogenesis, she studies how Aβ and tau impact brain cell physiology. Intrigued by AD-related crosstalk between the peripheral immune system and CNS, she collaborates on therapeutic targets and blood biomarkers for early AD detection. Her extensive research includes 210+ SCI papers and 27 patents.