Resuscitation @ PERC

Pan-Asian Resuscitation Outcomes Study (PAROS)

Resuscitation

Pan-Asian Resuscitation Outcomes Study (PAROS) - Phase 2

Maeve Pek, Nur Shahidah

 

Background

Dispatcher-assisted CPR (DA-CPR) has the potential to deliver early bystander CPR (BCPR). This multi-national study in the Asia-Pacific evaluated the impact of a DA-CPR program on BCPR rates and OHCA survival. 

 

Methods

OHCA cases between January 2009 and June 2018 from 13 participating countries in the PAROS CRN were included. Based on their capacity, sites either implemented a DA-CPR served as controls. Primary outcome was survival-to-discharge/30th day post-arrest. 

 

Results

170,690 cases were analysed. Before-after comparison showed that odds of survival to discharge were higher in the 'intervention' period in all three groups: comprehensive OR 1.09, 95%CI (1.0-1.19); basic OR 1.14, 95%CI (1.08-1.2); and control OR 1.25, 95%CI (1.02-1.53). The comprehensive group showed the highest before-after increase in BCPR: comprehensive OR 2.14, 95%CI (2.02-2.25); basic OR 1.09, 95%CI (1.06-1.11); and control OR 1.15, 95%CI (1.03-1.28). 

 

Conclusion

This study evaluated the real-world impact of a DA-CPR program across different EMS systems and demonstrated that a comprehensive DA-CPR program had the most impact on BCPR and survival with favorable neurological outcome. 

 

Publications

PAROS

  • Ong ME, Shin SD, Tanaka H, Ma MH, Khruekarnchana P, Hisamuddin N, Atilla R, Middleton P, Kajino K, Leong BS, Khan MN. Pan-Asian Resuscitation Outcomes Study (PAROS): rationale, methodology, and implementation. Acad Emerg Med. 2011 Aug;18(8):890-7. doi: 10.1111/j.1553-2712.2011.01132.x. PMID: 21843225.

  • Ong ME, Shin SD, De Souza NN, Tanaka H, Nishiuchi T, Song KJ, Ko PC, Leong BS, Khunkhlai N, Naroo GY, Sarah AK, Ng YY, Li WY, Ma MH; PAROS Clinical Research Network. Outcomes for out-of-hospital cardiac arrests across 7 countries in Asia: The Pan Asian Resuscitation Outcomes Study (PAROS). Resuscitation. 2015 Nov;96:100-8. doi: 10.1016/j.resuscitation.2015.07.026. Epub 2015 Jul 30. Erratum in: Resuscitation. 2016 Jan;98:125-6. PMID: 26234891.

  • Ong ME, Cho J, Ma MH, Tanaka H, Nishiuchi T, Al Sakaf O, Abdul Karim S, Khunkhlai N, Atilla R, Lin CH, Shahidah N, Lie D, Shin SD; PAROS Investigators. Comparison of emergency medical services systems in the pan-Asian resuscitation outcomes study countries: Report from a literature review and survey. Emerg Med Australas. 2013 Feb;25(1):55-63. doi: 10.1111/1742-6723.12032. Epub 2012 Dec 19. PMID: 23379453.

  • Wong XY, Ang YK, Li K, Chin YH, Lam SSW, Tan KBK, Chua MCH, Ong MEH, Liu N, Pourghaderi AR, Ho AFW; PAROS Singapore Investigators. Development and validation of the SARICA score to predict survival after return of spontaneous circulation in out of hospital cardiac arrest using an interpretable machine learning framework. Resuscitation. 2022 Jan;170:126-133. doi: 10.1016/j.resuscitation.2021.11.029. Epub 2021 Nov 26. PMID: 34843878.

  • Limkakeng AT, Ye JJ, Staton C, Ng YY, Leong BSH, Shahidah N, Yazid M, Gordee A, Kuchibhatla M, Ong MEH; Singapore PAROS Investigators. Impact of dispatcher-assisted cardiopulmonary resuscitation on performance of termination of resuscitation criteria. Resuscitation. 2022 Jan;170:160-166. doi: 10.1016/j.resuscitation.2021.11.034. Epub 2021 Dec 3. PMID: 34871758; PMCID: PMC9272777.

  • Ong MEH, Shin SD, Ko PC, Lin X, Ma MH, Ryoo HW, Wong KD, Supasaowapak J, Lin CH, Kuo CW, Rao R, Cai W, Gaerlan FJ, Khursheed M, Son DN, Sarah K, El Sayed M, Al Qahtani S, Tanaka H. International multi-center real world implementation trial to increase out-of-hospital cardiac arrest survival with a dispatcher-assisted cardio-pulmonary resuscitation package (Pan-Asian resuscitation outcomes study phase 2). Resuscitation. 2022 Feb;171:80-89. doi: 10.1016/j.resuscitation.2021.12.032. Epub 2021 Dec 30. PMID: 34974143.

  • Ong ME, Shin SD, Tanaka H, Ma MH, Nishiuchi T, Lee EJ, Ko PC, Edwin Doctor N, Khruekarnchana P, Naroo GY, Wong KD, Nakagawa T, Ryoo HW, Lin CH, Goh ES, Khunkhlai N, Alsakaf OA, Hisamuddin NA, Bobrow BJ, McNally B, Assam PN, Chan ES. Rationale, Methodology, and Implementation of a Dispatcher-assisted Cardiopulmonary Resuscitation Trial in the Asia-Pacific (Pan-Asian Resuscitation Outcomes Study Phase 2). Prehosp Emerg Care. 2015 January-March;19(1):87-95. doi: 10.3109/10903127.2014.942482. Epub 2014 Aug 25. PMID: 25152997.

  • Chia MY, Lu QS, Rahman NH, Doctor NE, Nishiuchi T, Leong BS, Tham LP, Goh ES, Tiah L, Monsomboon A, Ong ME; PAROS Clinical Research Network. Characteristics and outcomes of young adults who suffered an out-of-hospital cardiac arrest (OHCA). Resuscitation. 2017 Feb;111:34-40. doi: 10.1016/j.resuscitation.2016.11.019. Epub 2016 Dec 5. PMID: 27923113.

  • Tanaka H, Ong MEH, Siddiqui FJ, Ma MHM, Kaneko H, Lee KW, Kajino K, Lin CH, Gan HN, Khruekarnchana P, Alsakaf O, Rahman NH, Doctor NE, Assam P, Shin SD; PAROS Clinical Research Network. Modifiable Factors Associated With Survival After Out-of-Hospital Cardiac Arrest in the Pan-Asian Resuscitation Outcomes Study. Ann Emerg Med. 2018 May;71(5):608-617.e15. doi: 10.1016/j.annemergmed.2017.07.484. Epub 2017 Oct 3. PMID: 28985969.

  • Kim YJ, Ryoo HW, Shin SD, Song KJ, Ro YS, Lee KW, Ma MH, Ko PC, Gan HN, Shahidah N. Diurnal variation in outcomes after out-of-hospital cardiac arrest in Asian communities: The Pan-Asian Resuscitation Outcomes Study. Emerg Med Australas. 2017 Oct;29(5):551-562. doi: 10.1111/1742-6723.12822. Epub 2017 Jun 9. PMID: 28597966.

  • Doctor NE, Ahmad NS, Pek PP, Yap S, Ong ME. The Pan-Asian Resuscitation Outcomes Study (PAROS) clinical research network: what, where, why and how. Singapore Med J. 2017 Jul;58(7):456-458. doi: 10.11622/smedj.2017057. PMID: 28741005; PMCID: PMC5523101.

  • Lee MH, Fook-Chong S, Wah W, Shin SD, Nishiuchi T, Ko PC, Naroo GY, Wong KD, Tiah L, Monsomboon A, Siddiqui FJ, Ong ME; PAROS Clinical Research Network. Effect of known history of heart disease on survival outcomes after out-of-hospital cardiac arrests. Emerg Med Australas. 2018 Feb;30(1):67-76. doi: 10.1111/1742-6723.12809. Epub 2017 May 31. PMID: 28568968.

  • Kim TH, Lee K, Shin SD, Ro YS, Tanaka H, Yap S, Wong KD, Ng YY, Piyasuwankul T, Leong B. Association of the Emergency Medical Services-Related Time Interval with Survival Outcomes of Out-of-Hospital Cardiac Arrest Cases in Four Asian Metropolitan Cities Using the Scoop-and-Run Emergency Medical Services Model. J Emerg Med. 2017 Nov;53(5):688-696.e1. doi: 10.1016/j.jemermed.2017.08.076. PMID: 29128033.

  • Irfan FB, Bhutta ZA, Castren M, Straney L, Djarv T, Tariq T, Thomas SH, Alinier G, Al Shaikh L, Owen RC, Al Suwaidi J, Shuaib A, Singh R, Cameron PA. Epidemiology and outcomes of out-of-hospital cardiac arrest in Qatar: A nationwide observational study. Int J Cardiol. 2016 Nov 15;223:1007-1013. doi: 10.1016/j.ijcard.2016.08.299. Epub 2016 Aug 24. PMID: 27611569.

  • Shin SD, Kitamura T, Hwang SS, Kajino K, Song KJ, Ro YS, Nishiuchi T, Iwami T; Seoul–Osaka Resuscitation Study (SORS) Group. Association between resuscitation time interval at the scene and neurological outcome after out-of-hospital cardiac arrest in two Asian cities. Resuscitation. 2014 Feb;85(2):203-10. doi: 10.1016/j.resuscitation.2013.10.021. Epub 2013 Oct 31. PMID: 24184782.

  • Bray JE, Grasner JT, Nolan JP, Iwami T, Ong MEH, Finn J, McNally B, Nehme Z, Sasson C, Tijssen J, Lim SL, Tjelmeland I, Wnent J, Dicker B, Nishiyama C, Doherty Z, Welsford M, Perkins GD; International Liaison Committee on Resuscitation. Cardiac Arrest and Cardiopulmonary Resuscitation Outcome Reports: 2024 Update of the Utstein Out-of-Hospital Cardiac Arrest Registry Template. Circulation. 2024 Aug 27;150(9):e203-e223. doi: 10.1161/CIR.0000000000001243. Epub 2024 Jul 24. PMID: 39045706.

  • Okada Y, Shahidah N, Ng YY, Chia MYC, Gan HN, Leong BSH, Mao DR, Ng WM, Edwin N, Kiguchi T, Nishioka N, Kitamura T, Iwami T, Ong MEH. Comparing outcomes of out-of-hospital cardiac arrest patients with initial shockable rhythm in Singapore and Osaka using population-based databases. Crit Care. 2023 Dec 6;27(1):479. doi: 10.1186/s13054-023-04771-5. PMID: 38057881; PMCID: PMC10699037.

  • Tjelmeland IBM, Wnent J, Masterson S, Kramer-Johansen J, Ong MEH, Smith K, Skogvoll E, Lefering R, Lim SL, Liu N, Dicker B, Swain A, Ball S, Gräsner JT; CARES Surveillance Group and the Lockdown and bystander CPR group. Did lockdown influence bystanders' willingness to perform cardiopulmonary resuscitation? A worldwide registry-based perspective. Resuscitation. 2023 May;186:109764. doi: 10.1016/j.resuscitation.2023.109764. Epub 2023 Mar 18. PMID: 36934834.

  • Rajendram MF, Zarisfi F, Xie F, Shahidah N, Pek PP, Yeo JW, Tan BY, Ma M, Do Shin S, Tanaka H, Ong MEH, Liu N, Ho AFW. External validation of the Survival After ROSC in Cardiac Arrest (SARICA) score for predicting survival after return of spontaneous circulation using multinational pan-asian cohorts. Front Med (Lausanne). 2022 Sep 8;9:930226. doi: 10.3389/fmed.2022.930226. PMID: 36160129; PMCID: PMC9492983.

  • Liu N, Ning Y, Ong MEH, Saffari SE, Ryu HH, Kajino K, Lin CH, Karim SA, Rao GVR, Ho AFW, Lim SL, Siddiqui FJ; PAROS Clinical Research Network Investigators. Gender disparities among adult recipients of layperson bystander cardiopulmonary resuscitation by location of cardiac arrest in Pan-Asian communities: A registry-based study. EClinicalMedicine. 2022 Feb 12;44:101293. doi: 10.1016/j.eclinm.2022.101293. PMID: 35198919; PMCID: PMC8850341.

  • Riyapan S, Chantanakomes J, Roongsaenthong P, Tianwibool P, Wittayachamnankul B, Supasaovapak J, Pansiritanachot W. Impact of the COVID-19 outbreak on out-of-hospital cardiac arrest management and outcomes in a low-resource emergency medical service system: a perspective from Thailand. Int J Emerg Med. 2022 Jun 9;15(1):26. doi: 10.1186/s12245-022-00429-1. PMID: 35681113; PMCID: PMC9178319.

  • Goto Y, Maeda T, Goto Y. Impact of dispatcher-assisted bystander cardiopulmonary resuscitation on neurological outcomes in children with out-of-hospital cardiac arrests: a prospective, nationwide, population-based cohort study. J Am Heart Assoc. 2014 Apr 30;3(3):e000499. doi: 10.1161/JAHA.113.000499. PMID: 24785780; PMCID: PMC4309039.

  • Ko SY, Ahn KO, Do Shin S, Park JH, Lee SY. Effects of telephone-assisted cardiopulmonary resuscitation on the sex disparity in provision of bystander cardiopulmonary resuscitation in public locations. Resuscitation. 2021 Jul;164:101-107. doi: 10.1016/j.resuscitation.2021.03.014. Epub 2021 Mar 24. PMID: 33774152.

  • Kiguchi T, Okubo M, Nishiyama C, Maconochie I, Ong MEH, Kern KB, Wyckoff MH, McNally B, Christensen EF, Tjelmeland I, Herlitz J, Perkins GD, Booth S, Finn J, Shahidah N, Shin SD, Bobrow BJ, Morrison LJ, Salo A, Baldi E, Burkart R, Lin CH, Jouven X, Soar J, Nolan JP, Iwami T. Out-of-hospital cardiac arrest across the World: First report from the International Liaison Committee on Resuscitation (ILCOR). Resuscitation. 2020 Jul;152:39-49. doi: 10.1016/j.resuscitation.2020.02.044. Epub 2020 Apr 6. PMID: 32272235.

  • Okada Y, Shahidah N, Ng YY, Chia MYC, Gan HN, Leong BSH, Mao DR, Ng WM, Irisawa T, Yamada T, Nishimura T, Kiguchi T, Kishimoto M, Matsuyama T, Nishioka N, Kiyohara K, Kitamura T, Iwami T, Ong MEH. Outcome assessment for out-of-hospital cardiac arrest patients in Singapore and Japan with initial shockable rhythm. Crit Care. 2023 Sep 12;27(1):351. doi: 10.1186/s13054-023-04636-x. PMID: 37700335; PMCID: PMC10496207.

  • Tham LP, Fook-Chong S, Binte Ahmad NS, Ho AF, Tanaka H, Shin SD, Ko PC, Wong KD, Jirapong S, Rao GVR, Cai W, Al Qahtani S, Ong MEH; Pan-Asian Resuscitation Outcomes Study Clinical Research Network. Pre-hospital airway management and survival outcomes after paediatric out-of-hospital cardiac arrests. Resuscitation. 2022 Jul;176:9-18. doi: 10.1016/j.resuscitation.2022.04.018. Epub 2022 Apr 26. PMID: 35483494.

  • Liu N, Liu M, Chen X, Ning Y, Lee JW, Siddiqui FJ, Saffari SE, Ho AFW, Shin SD, Ma MH, Tanaka H, Ong MEH; PAROS Clinical Research Network Investigators. Development and validation of an interpretable prehospital return of spontaneous circulation (P-ROSC) score for patients with out-of-hospital cardiac arrest using machine learning: A retrospective study. EClinicalMedicine. 2022 May 6;48:101422. doi: 10.1016/j.eclinm.2022.101422. PMID: 35706500; PMCID: PMC9096672.

  • Nishiyama C, Kiguchi T, Okubo M, Alihodžić H, Al-Araji R, Baldi E, Beganton F, Booth S, Bray J, Christensen E, Cresta R, Finn J, Gräsner JT, Jouven X, Kern KB, Maconochie I, Masterson S, McNally B, Nolan JP, Eng Hock Ong M, Perkins GD, Ho Park J, Ristau P, Savastano S, Shahidah N, Do Shin S, Soar J, Tjelmeland I, Quinn M, Wnent J, Wyckoff MH, Iwami T. Three-year trends in out-of-hospital cardiac arrest across the world: Second report from the International Liaison Committee on Resuscitation (ILCOR). Resuscitation. 2023 May;186:109757. doi: 10.1016/j.resuscitation.2023.109757. Epub 2023 Mar 2. PMID: 36868553.

  • Sirikul W, Piankusol C, Wittayachamnankul B, Riyapan S, Supasaovapak J, Wongtanasarasin W, McNally B. A retrospective multi-centre cohort study: Pre-hospital survival factors of out-of-hospital cardiac arrest (OHCA) patients in Thailand. Resusc Plus. 2022 Jan 8;9:100196. doi: 10.1016/j.resplu.2021.100196. PMID: 35036967; PMCID: PMC8749449.

  • Do SN, Luong CQ, Pham DT, Nguyen CV, Ton TT, Pham TT, Hoang QT, Hoang HT, Nguyen DT, Khuong DQ, Nguyen QH, Nguyen TA, Pham HT, Nguyen MH, McNally BF, Ong ME, Nguyen AD. Survival after out-of-hospital cardiac arrest, Viet Nam: multicentre prospective cohort study. Bull World Health Organ. 2021 Jan 1;99(1):50-61. doi: 10.2471/BLT.20.269837. Epub 2020 Oct 28. PMID: 33658734; PMCID: PMC7924896.

Singapore OHCA

  • Nazeha N, Ong MEH, Limkakeng AT Jr, Ye JJ, Joiner AP, Blewer A, Shahidah N, Nadarajan GD, Mao DR, Graves N. A hypothetical implementation of 'Termination of Resuscitation' protocol for out-of-hospital cardiac arrest. Resusc Plus. 2021 Mar 3;6:100092. doi: 10.1016/j.resplu.2021.100092. PMID: 34223357; PMCID: PMC8244430.

  • Dainty KN, Yng Ng Y, Pin Pek P, Koster RW, Eng Hock Ong M. Wolf creek XVII part 4: Amplifying lay-rescuer response. Resusc Plus. 2024 Jan 12;17:100547. doi: 10.1016/j.resplu.2023.100547. PMID: 38292468; PMCID: PMC10827540.

  • White AE, Ho AF, Shahidah N, Asyikin N, Liew LX, Pek PP, Kua JP, Chia MY, Ng YY, Arulanandam S, Leong SB, Ong ME. An essential review of Singapore's response to out-of-hospital cardiac arrests: improvements over a ten-year period. Singapore Med J. 2021 Aug;62(8):438-443. doi: 10.11622/smedj.2021114. PMID: 35001113; PMCID: PMC8804483.

  • Chua ISY, Fook-Chong SMC, Shahidah N, Ng YY, Chia MYC, Mao DR, Leong BSH, Cheah SO, Gan HN, Doctor NE, Tham LP, Ong MEH; Singapore PAROS investigators. The association between mode of transport and out-of-hospital cardiac arrest outcomes in Singapore. Resuscitation. 2022 Apr;173:136-143. doi: 10.1016/j.resuscitation.2022.01.020. Epub 2022 Jan 25. PMID: 35090972.

  • Ho AFW, Lee KY, Nur S, Fook SC, Pek PP, Tanaka H, Sang DS, Chow PI, Tan BY, Lim SL, Ma MH, Ryoo HW, Lin CH, Kuo CW, Kajino K, Ong MEH; Pan-Asian Resuscitation Outcomes Study Clinical Research Network. Association between Conversion to Shockable Rhythms and Survival with Favorable Neurological Outcomes for Out-of-Hospital Cardiac Arrests. Prehosp Emerg Care. 2024;28(1):126-134. doi: 10.1080/10903127.2023.2212039. Epub 2023 Jun 1. PMID: 37171870.

  • Jung SW, Kim KH, Park JH, Kim TH, Jeong J, Ro YS, Hong KJ, Song KJ, Shin SD. Association between the relationship of bystander and neurologic recovery in pediatric out-of-hospital cardiac arrest. Resuscitation. 2023 Aug;189:109839. doi: 10.1016/j.resuscitation.2023.109839. Epub 2023 May 15. PMID: 37196804.

  • Lee MHM, Chia MYC, Fook-Chong S, Shahidah N, Tagami T, Ryu HH, Lin CH, Karim SA, Jirapong S, Rao HVR, Cai W, Velasco BP, Khan NU, Son DN, Naroo GY, El Sayed M, Ong MEH. Characteristics and Outcomes of Traumatic Cardiac Arrests in the Pan-Asian Resuscitation Outcomes Study. Prehosp Emerg Care. 2023;27(8):978-986. doi: 10.1080/10903127.2022.2113941. Epub 2022 Sep 6. PMID: 35994382.

  • Li T, Yap J, Chng WQ, Tay JCK, Shahidah N, Yeo C, Gan HN, Tong KL, Ng YY, Wu JH, Wang M, Ong MEH, Ching CK. Clinicopathological correlates of out-of-hospital cardiac arrests. J Arrhythm. 2022 Mar 29;38(3):416-424. doi: 10.1002/joa3.12705. PMID: 35785374; PMCID: PMC9237307.

  • Chia MYC, Kwa TPW, Wah W, Yap S, Doctor NE, Ng YY, Mao DR, Leong BS, Gan HN, Tham LP, Cheah SO, Ong MEH. Comparison of Outcomes and Characteristics of Emergency Medical Services (EMS)-Witnessed, Bystander-Witnessed, and Unwitnessed Out-of-Hospital Cardiac Arrests in Singapore. Prehosp Emerg Care. 2019 Nov-Dec;23(6):847-854. doi: 10.1080/10903127.2019.1587124. Epub 2019 Mar 27. PMID: 30795712.

  • Wah W, Wai KL, Pek PP, Ho AFW, Alsakaf O, Chia MYC, Noor JM, Kajino K, De Souza NNA, Ong MEH; PAROS Investigators. Conversion to shockable rhythms during resuscitation and survival for out-of hospital cardiac arrest. Am J Emerg Med. 2017 Feb;35(2):206-213. doi: 10.1016/j.ajem.2016.10.042. Epub 2016 Oct 25. PMID: 27810251.

  • Nazeha N, Mao DR, Hong D, Shahidah N, Chua ISY, Ng YY, Leong BSH, Tiah L, Chia MYC, Ng WM, Doctor NE, Ong MEH, Graves N. Cost-effectiveness analysis of a 'Termination of Resuscitation' protocol for the management of out-of-hospital cardiac arrest. Resuscitation. 2024 Sep;202:110323. doi: 10.1016/j.resuscitation.2024.110323. Epub 2024 Jul 17. PMID: 39029582.

  • Ong ME, Annathurai A, Shahidah A, Leong BS, Ong VY, Tiah L, Ang SH, Yong KL, Sultana P. Cardiopulmonary resuscitation interruptions with use of a load-distributing band device during emergency department cardiac arrest. Ann Emerg Med. 2010 Sep;56(3):233-41. doi: 10.1016/j.annemergmed.2010.01.004. Epub 2010 Mar 12. PMID: 20138401.

  • Wong XY, Ang YK, Li K, Chin YH, Lam SSW, Tan KBK, Chua MCH, Ong MEH, Liu N, Pourghaderi AR, Ho AFW; PAROS Singapore Investigators. Development and validation of the SARICA score to predict survival after return of spontaneous circulation in out of hospital cardiac arrest using an interpretable machine learning framework. Resuscitation. 2022 Jan;170:126-133. doi: 10.1016/j.resuscitation.2021.11.029. Epub 2021 Nov 26. PMID: 34843878.

  • Lo CYZ, Fook-Chong S, Shahidah N, White AE, Tan CK, Ng YY, Tiah L, Chia MYC, Leong BSH, Mao DR, Ng WM, Doctor NE, Ong MEH, Siddiqui FJ. Does witness type affect the chance of receiving bystander CPR in out-of-hospital cardiac arrest? Resuscitation. 2023 Aug;189:109873. doi: 10.1016/j.resuscitation.2023.109873. Epub 2023 Jun 14. PMID: 37327852.

  • Lam SS, Zhang J, Zhang ZC, Oh HC, Overton J, Ng YY, Ong ME. Dynamic ambulance reallocation for the reduction of ambulance response times using system status management. Am J Emerg Med. 2015 Feb;33(2):159-66. doi: 10.1016/j.ajem.2014.10.044. Epub 2014 Nov 8. PMID: 25488335.

  • Lim SL, Lau YH, Chan MY, Chua T, Tan HC, Foo D, Lim ZY, Liew BW, Shahidah N, Mao DR, Cheah SO, Chia MYC, Gan HN, Leong BSH, Ng YY, Yeo KK, Ong MEH. Early Coronary Angiography Is Associated with Improved 30-Day Outcomes among Patients with Out-of-Hospital Cardiac Arrest. J Clin Med. 2021 Nov 6;10(21):5191. doi: 10.3390/jcm10215191. PMID: 34768711; PMCID: PMC8584598.

  • Lee MH, Fook-Chong S, Wah W, Shin SD, Nishiuchi T, Ko PC, Naroo GY, Wong KD, Tiah L, Monsomboon A, Siddiqui FJ, Ong ME; PAROS Clinical Research Network. Effect of known history of heart disease on survival outcomes after out-of-hospital cardiac arrests. Emerg Med Australas. 2018 Feb;30(1):67-76. doi: 10.1111/1742-6723.12809. Epub 2017 May 31. PMID: 28568968.

  • Lian TW, Allen JC, Ho AFW, Lim SH, Shahidah N, Ng YY, Doctor N, Leong BSH, Gan HN, Mao DR, Chia MYC, Cheah SO, Tham LP, Ong MEH. Effect of vertical location on survival outcomes for out-of-hospital cardiac arrest in Singapore. Resuscitation. 2019 Jun;139:24-32. doi: 10.1016/j.resuscitation.2019.03.042. Epub 2019 Apr 3. PMID: 30953711.

  • Tay PJM, Pek PP, Fan Q, Ng YY, Leong BS, Gan HN, Mao DR, Chia MYC, Cheah SO, Doctor N, Tham LP, Ong MEH. Effectiveness of a community based out-of-hospital cardiac arrest (OHCA) interventional bundle: Results of a pilot study. Resuscitation. 2020 Jan 1;146:220-228. doi: 10.1016/j.resuscitation.2019.10.015. Epub 2019 Nov 14. PMID: 31669756.

  • Rakun A, Allen J, Shahidah N, Ng YY, Leong BS, Gan HN, Mao D, Chia MYC, Cheah SO, Tham LP, Ong MEH. Ethnic and Neighborhood Socioeconomic Differences In Incidence and Survival From Out-Of-Hospital Cardiac Arrest In Singapore. Prehosp Emerg Care. 2019 Sep-Oct;23(5):619-630. doi: 10.1080/10903127.2018.1558317. Epub 2019 Jan 31. PMID: 30582395.

  • Guerrero A, Blewer AL, Joiner AP, Leong BSH, Shahidah N, Pek PP, Ng YY, Arulanandam S, Østbye T, Gordee A, Kuchibhatla M, Ong MEH. Evaluation of telephone-assisted cardiopulmonary resuscitation recommendations for out-of-hospital cardiac arrest. Resuscitation. 2022 Sep;178:87-95. doi: 10.1016/j.resuscitation.2022.07.021. Epub 2022 Jul 21. PMID: 35870555; PMCID: PMC10013180.

  • Earnest A, Tan SB, Shahidah N, Ong ME. Geographical variation in ambulance calls is associated with socioeconomic status. Acad Emerg Med. 2012 Feb;19(2):180-8. doi: 10.1111/j.1553-2712.2011.01280.x. PMID: 22320368.

  • Ho AFW, Tan TXZ, Latiff E, Shahidah N, Ng YY, Leong BS, Lim SL, Pek PP, Gan HN, Mao DR, Chia MYC, Cheah SO, Tham LP, Ong MEH. Assessing unrealised potential for organ donation after out-of-hospital cardiac arrest. Scand J Trauma Resusc Emerg Med. 2021 Jul 28;29(1):105. doi: 10.1186/s13049-021-00924-z. PMID: 34321054; PMCID: PMC8317313.

  • Blewer AL, Ho AFW, Shahidah N, White AE, Pek PP, Ng YY, Mao DR, Tiah L, Chia MY, Leong BS, Cheah SO, Tham LP, Kua JPH, Arulanandam S, Østbye T, Bosworth HB, Ong MEH. Impact of bystander-focused public health interventions on cardiopulmonary resuscitation and survival: a cohort study. Lancet Public Health. 2020 Aug;5(8):e428-e436. doi: 10.1016/S2468-2667(20)30140-7. PMID: 32768435.

  • Goh JL, Pek PP, Fook-Chong SMC, Ho AFW, Siddiqui FJ, Leong BS, Mao DRH, Ng W, Tiah L, Chia MY, Tham LP, Shahidah N, Arulanandam S, Ong MEH; PAROS Clinical Research Network. Impact of time-to-compression on out-of-hospital cardiac arrest survival outcomes: A national registry study. Resuscitation. 2023 Sep;190:109917. doi: 10.1016/j.resuscitation.2023.109917. Epub 2023 Jul 26. PMID: 37506813.

  • Lim SL, Smith K, Dyson K, Chan SP, Earnest A, Nair R, Bernard S, Leong BS, Arulanandam S, Ng YY, Ong MEH. Incidence and Outcomes of Out-of-Hospital Cardiac Arrest in Singapore and Victoria: A Collaborative Study. J Am Heart Assoc. 2020 Nov 3;9(21):e015981. doi: 10.1161/JAHA.119.015981. Epub 2020 Oct 23. PMID: 33094661; PMCID: PMC7763419.

  • Ng JYX, Sim ZJ, Siddiqui FJ, Shahidah N, Leong BS, Tiah L, Ng YY, Blewer A, Arulanandam S, Lim SL, Ong MEH, Ho AFW. Incidence, characteristics and complications of dispatcher-assisted cardiopulmonary resuscitation initiated in patients not in cardiac arrest. Resuscitation. 2022 Jan;170:266-273. doi: 10.1016/j.resuscitation.2021.09.022. Epub 2021 Oct 6. PMID: 34626729.

  • Ong CA, Nadarajan GD, Fook-Chong S, Shahidah N, Arulanandam S, Ng YY, Chia MY, Tiah L, Mao DR, Ng WM, Leong BS, Doctor N, Ong ME, Siddiqui FJ. Increasing neurologically intact survival after out-of-hospital cardiac arrest among elderly: Singapore Experience. Resusc Plus. 2024 Feb 9;17:100573. doi: 10.1016/j.resplu.2024.100573. PMID: 38370311; PMCID: PMC10869923.

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