This section gives an overview of the commonly used drugs (excluding opioids) to manage symptoms in patients with terminal illnesses. The information includes basic dosage information as well as indications for use and potential side effects. Please note that non-opioid drugs commonly used in palliative care in Singapore are shown here but the list is NOT exhaustive and neither are the side effects nor indications. Doses are for adults only. Please check with pharmacy colleagues for dose adjustments (if any) in renal or liver impairment. Unless otherwise indicated, use water for injection for dilution in continuous subcutaneous infusions.
*For information on opioids, please search and refer to the drugs with their given context.
Celecoxib
Route, Dosage and Frequency
ROUTE
|
DOSAGE AND FREQUENCY
|
| PO |
100-200mg b.d. (max dose 400mg/day) |
Other Information
Indications
Inflammatory pain, Bone pain.
Side-Effects
Diarrhoea, Dyspepsia, Cardiovascular events, Peripheral oedema.
Remarks
COX-2 inhibitor. Caution in elderly, cardiac disease and peripheral vascular disease. Less risk for gastrointestinal events but similar risk for cardiovascular events compared to non-steroidal anti-inflammatory drugs.
Reference
- Watson M. Oxford Handbook of Palliative Care. Oxford, NY: Oxford University Press; 2009.