This section gives an overview of the commonly used drugs (excluding opioids) to manage symptoms in patients with terminal illnesses. The information includes basic dosage information as well as indications for use and potential side effects. Please note that non-opioid drugs commonly used in palliative care in Singapore are shown here but the list is NOT exhaustive and neither are the side effects nor indications. Doses are for adults only. Please check with pharmacy colleagues for dose adjustments (if any) in renal or liver impairment. Unless otherwise indicated, use water for injection for dilution in continuous subcutaneous infusions.
*For information on opioids, please search and refer to the drugs with their given context.
Domperidone
Route, Dosage and Frequency
ROUTE
|
DOSAGE AND FREQUENCY
|
| PO |
10mg t.d.s. |
| PR |
30mg b.d. |
Other Information
Indications
Nausea and vomiting, Ileus, Dyspepsia.
Side-Effects
Seizures, Increased risk of ventricular arrhythmia and cardiac arrest for age >60years and on doses >30mg/day.
Remarks
Prokinetic anti-emetic. Less risk of extrapyramidal side effects than Metoclopramide. Stop if colic develops. Contraindicated in complete bowel obstruction, cardiac disease and prolonged QTc.
Reference
- Watson M. Oxford Handbook of Palliative Care. Oxford, NY: Oxford University Press; 2009.