This section gives an overview of the commonly used drugs (excluding opioids) to manage symptoms in patients with terminal illnesses. The information includes basic dosage information as well as indications for use and potential side effects. Please note that non-opioid drugs commonly used in palliative care in Singapore are shown here but the list is NOT exhaustive and neither are the side effects nor indications. Doses are for adults only. Please check with pharmacy colleagues for dose adjustments (if any) in renal or liver impairment. Unless otherwise indicated, use water for injection for dilution in continuous subcutaneous infusions.
*For information on opioids, please search and refer to the drugs with their given context.
Fluconazole
Route, Dosage and Frequency
ROUTE
|
DOSAGE AND FREQUENCY
|
| PO |
For oral/oesophageal candidiasis, 200mg loading dose, then 50-100mg each morning for 7-14 days. For vaginal candidiasis, 150mg once only. |
Other Information
Indications
Candidiasis (thrush).
Side-Effects
Vomiting, Dyspepsia.
Remarks
Anti-fungal. Inhibitor of P450 cytochrome system, so may interact with many drugs. Not to give with QTc-prolonging drugs. Reduce dose if creatinine clearance <50ml/min.
Reference
- Watson M. Oxford Handbook of Palliative Care. Oxford, NY: Oxford University Press; 2009.