This section gives an overview of the commonly used drugs (excluding opioids) to manage symptoms in patients with terminal illnesses. The information includes basic dosage information as well as indications for use and potential side effects. Please note that non-opioid drugs commonly used in palliative care in Singapore are shown here but the list is NOT exhaustive and neither are the side effects nor indications. Doses are for adults only. Please check with pharmacy colleagues for dose adjustments (if any) in renal or liver impairment. Unless otherwise indicated, use water for injection for dilution in continuous subcutaneous infusions.
*For information on opioids, please search and refer to the drugs with their given context.
Granisetron
Route, Dosage and Frequency
ROUTE
|
DOSAGE AND FREQUENCY
|
| PO/IV/SC |
1-2mg once daily |
Other Information
Indications
Chemotherapy or radiation-induced vomiting, Intractable vomiting in advanced cancer (when used with other anti-emetics), Pruritus from spinal opioids.
Side-Effects
Constipation, Headache, Dizziness.
Remarks
5HT3 receptor antagonist. Use separate syringe driver or infusion pump (incompatible with other drugs). No need dose reduction in liver or renal impairment.
Reference
- Watson M. Oxford Handbook of Palliative Care. Oxford, NY: Oxford University Press; 2009.