This section gives an overview of the commonly used drugs (excluding opioids) to manage symptoms in patients with terminal illnesses. The information includes basic dosage information as well as indications for use and potential side effects. Please note that non-opioid drugs commonly used in palliative care in Singapore are shown here but the list is NOT exhaustive and neither are the side effects nor indications. Doses are for adults only. Please check with pharmacy colleagues for dose adjustments (if any) in renal or liver impairment. Unless otherwise indicated, use water for injection for dilution in continuous subcutaneous infusions.
*For information on opioids, please search and refer to the drugs with their given context.
Levetiracetam
Route, Dosage and Frequency
ROUTE
|
DOSAGE AND FREQUENCY
|
| PO/IV |
250-500mg b.d. Increase as needed every 2 weeks by 250-500mg to max 1.5g b.d. (Infuse IV bolus over 15min) |
Other Information
Side-Effects
Fatigue, Drowsiness.
Remarks
Anti-epileptic (SV2A ligand). Dilute in 0.9% saline for IV use. CSCI has been used in case reports. Adjust dose in renal impairments. Do not stop abruptly (risk of rebound seizures). Less drug interactions compared to other anti-epileptics.
Reference
- Watson M. Oxford Handbook of Palliative Care. Oxford, NY: Oxford University Press; 2009.