This section gives an overview of the commonly used drugs (excluding opioids) to manage symptoms in patients with terminal illnesses. The information includes basic dosage information as well as indications for use and potential side effects. Please note that non-opioid drugs commonly used in palliative care in Singapore are shown here but the list is NOT exhaustive and neither are the side effects nor indications. Doses are for adults only. Please check with pharmacy colleagues for dose adjustments (if any) in renal or liver impairment. Unless otherwise indicated, use water for injection for dilution in continuous subcutaneous infusions.
*For information on opioids, please search and refer to the drugs with their given context.
Midazolam
Route, Dosage and Frequency
ROUTE
|
DOSAGE AND FREQUENCY
|
| SC |
1-2.5 mg p.r.n. |
| CSCI |
10-60 mg over 24h (may be higher if symptoms uncontrolled) |
Other Information
Indications
Delirium, Agitation, Anxiety, Sedation, Seizures.
Side-Effects
Drowsiness, Dizziness, Ataxia, Fatigue, Cognitive impairment.
Remarks
Benzodiazepine. Shorter duration of action than Diazepam. Replacement for anticonvulsants in the terminal phase. Compatible with most drugs in syringe driver or infusion pump.
Reference
- Watson M. Oxford Handbook of Palliative Care. Oxford, NY: Oxford University Press; 2009.