Duke-NUS Quantitative Biology and Medicine PhD candidate Yuan Han developed a new method to improve the accuracy of AI when it is used to diagnose a collapsed lung, or pneumothorax, by limiting the area of a chest x-ray that AI uses when interpreting the image.

Working with radiologists to understand how they read such x-rays, Mr Yuan created a simple filter or template that is applied over the x-ray to direct the AI’s analysis. With its sharpened focus, Mr Yuan’s model reduced the false positive rate, thereby improving the performance across twelve benchmark scenarios, demonstrating the value of incorporating clinical knowledge into AI-powered diagnostic methods.

Under the mentorship of Associate Professor Liu Nan from the Centre for Quantitative Medicine, who leads the Duke-NUS AI + Medical Sciences Initiative (DAISI), Mr Yuan published the findings in one of the top medical informatics journals, the Journal of Biomedical Informatics.

“I was happy and a bit surprised. The initial decision came in just one month, granting us an acceptance in principle, which was unexpected given that this journal typically takes half a year on average to accept a paper. This swift decision indicates that the integration of clinical knowledge and machine learning captured the interest of both the editors and the reviewers,” said Mr Yuan.