Directory

Long Service Award

Duke-NUS Medical School,2017

AAO Achievement Award

American Academy of Ophthalmology,2017

APAO Outstanding Service in Prevention of Blindness Award

Asia-Pacific Academy of Ophthalmology Congress,2014

APAO Achievement Award

Asia-Pacific Academy of Ophthalmology Congress,2014

I firmly believe clinician scientists play a crucial role in bridging the interface and gap between basic and clinical research, as well as medical care. Specifically, I am interested in translating gene discoveries to the prevention and treatment of eye diseases by synthesizing population-based data on genotype–phenotype correlation, and gene–environment and gene–gene interactions. From my perspective, as recent advances in genomic technologies leads to new gene discoveries for common diseases, clinical and epidemiological studies are needed to investigate the population distribution of gene variants and their interactions with modifiable risk factors, to provide the basis for novel clinical and public health interventions. Comprehensively characterizing the phenotypes and subgroups of diseases, together with advanced genomic analysis, will permit patient stratification and enable precision medicine, and therefore more accurate diagnosis can be made and more effective treatment can be tailored to individual needs.

Global prevalence of glaucoma and projections of glaucoma burden through 2040: A systematic review and meta-analysis.

Ophthalmology. – Tham YC, Li X, Wong TY, Quigley HA, Aung T, Cheng CY. (2014)

121 (11); 2081-90

Genome-wide analysis of multi-ancestry cohorts identifies new loci influencing intraocular pressure and susceptibility to glaucoma.

Nature Genetics. – Hysi PG‡, Cheng CY‡, Springelkamp H‡, Macgregor S‡, Bailey JN‡, Wojciechowski R‡, Vitart V, Nag A, Hewitt AW, Höhn R, Venturini C, Mirshahi A, Ramdas WD, Thorleifsson G, Vithana E, Khor CC, Stefansson AB, Liao J, Haines JL, Amin N, Wang YX, Wild PS, Ozel AB, Li JZ, Fleck BW, Zeller T, Staffieri SE, Teo YY, Cuellar-Partida G, Luo X, Allingham RR, Richards JE, Senft A, Karssen LC, Zheng Y, Bellenguez C, Xu L, Iglesias AI, Wilson JF, Kang JH, van Leeuwen EM, Jonsson V, Thorsteinsdottir U, Despriet DD, Ennis S, Moroi SE, Martin NG, Jansonius NM, Yazar S, Tai ES, Amouyel P, Kirwan J, van Koolwijk LM, Hauser MA, Jonasson F, Leo P, Loomis SJ, Fogarty R, Rivadeneira F, Kearns L, Lackner KJ, de Jong PT, Simpson CL, Pennell CE, Oostra BA, Uitterlinden AG, Saw SM, Lotery AJ, Bailey-Wilson JE, Hofman A, Vingerling JR, Maubaret C, Pfeiffer N, Wolfs RC, Lemij HG, Young TL, Pasquale LR, Delcourt C, Spector TD, Klaver CC, Small KS, Burdon KP, Stefansson K, Wong TY; BMES GWAS Group; NEIGHBORHOOD Consortium; Wellcome Trust Case Control Consortium 2, Viswanathan A, Mackey DA, Craig JE, Wiggs JL, van Duijn CM, Hammond CJ, Aung T. [‡Co-first author] (2014)

46 (10); 1126-30

Genome-wide association analysis identifies TXNRD2, ATXN2 and FOXC1 as susceptibility loci for primary open-angle glaucoma.

Nature Genetics. – Bailey JN, Loomis SJ, Kang JH, Allingham RR, Gharahkhani P, Khor CC, Burdon KP, Aschard H, Chasman DI, Igo RP Jr, Hysi PG, Glastonbury CA, Ashley-Koch A, Brilliant M, Brown AA, Budenz DL, Buil A, Cheng CY, Choi H, Christen WG, Curhan G, De Vivo I, Fingert JH, Foster PJ, Fuchs C, Gaasterland D, Gaasterland T, Hewitt AW, Hu F, Hunter DJ, Khawaja AP, Lee RK, Li Z, Lichter PR, Mackey DA, McGuffin P, Mitchell P, Moroi SE, Perera SA, Pepper KW, Qi Q, Realini T, Richards JE, Ridker PM, Rimm E, Ritch R, Ritchie M, Schuman JS, Scott WK, Singh K, Sit AJ, Song YE, Tamimi RM, Topouzis F, Viswanathan AC, Verma SS, Vollrath D, Wang JJ, Weisschuh N, Wissinger B, Wollstein G, Wong TY, Yaspan BL, Zack DJ, Zhang K, Study EN; ANZRAG Consortium, Weinreb RN, Pericak-Vance MA, Small K, Hammond CJ, Aung T, Liu Y, Vithana EN, MacGregor S, Craig JE, Kraft P, Howell G, Hauser MA, Pasquale LR, Haines JL, Wiggs JL. (2016)

48 (2); 189-94

Global prevalence of age-related macular degeneration and disease burden projection for 2020 and 2040: A systematic review and meta-analysis.

The Lancet Global Health. – Wong WL, Su X, Li X, Cheung CMG, Klein R, Cheng CY‡, Wong TY‡. [‡Co-last author] (2014)

2 (2); e106-16

New loci and coding variants confer risk for age-related macular degeneration in East Asians.

Nature Communications. – Cheng CY‡, Yamashiro K‡, Chen LJ‡, Ahn J‡, Huang L, Huang L, Cheung CM, Miyake M, Cackett PD, Yeo IY, Laude A, Mathur R, Pang J, Sim KS, Koh AH, Chen P, Lee SY, Wong D, Chan CM, Loh BK, Sun Y, Davila S, Nakata I, Nakanishi H, Akagi-Kurashige Y, Gotoh N, Tsujikawa A, Matsuda F, Mori K, Yoneya S, Sakurada Y, Iijima H, Iida T, Honda S, Lai TY, Tam PO, Chen H, Tang S, Ding X, Wen F, Lu F, Zhang X, Shi Y, Zhao P, Zhao B, Sang J, Gong B, Dorajoo R, Yuan JM, Koh WP, van Dam RM, Friedlander Y, Lin Y, Hibberd ML, Foo JN, Wang N, Wong CH, Tan GS, Park SJ, Bhargava M, Gopal L, Naing T, Liao J, Guan Ong P, Mitchell P, Zhou P, Xie X, Liang J, Mei J, Jin X, Saw SM, Ozaki M, Mizoguchi T, Kurimoto Y, Woo SJ, Chung H, Yu HG, Shin JY, Park DH, Kim IT, Chang W, Sagong M, Lee SJ, Kim HW, Lee JE, Li Y, Liu J, Teo YY, Heng CK, Lim TH, Yang SK, Song K, Vithana EN, Aung T, Bei JX, Zeng YX, Tai ES, Li XX, Yang Z, Park KH, Pang CP, Yoshimura N, Yin Wong T, Khor CC. [‡Co-first author] (2015)

6 6063-6063

Nine loci for ocular axial length identified through genome-wide association studies, including shared loci with refractive error.

American Journal of Human Genetics. – Cheng CY, Schache M, Ikram MK, Young TL, Guggenheim JA, Vitart V, MacGregor S, Verhoeven VJ, Barathi VA, Liao J, Hysi PG, Bailey-Wilson JE, St Pourcain B, Kemp JP, McMahon G, Timpson NJ, Evans DM, Montgomery GW, Mishra A, Wang YX, Wang JJ, Rochtchina E, Polasek O, Wright AF, Amin N, van Leeuwen EM, Wilson JF, Pennell CE, van Duijn CM, de Jong PT, Vingerling JR, Zhou X, Chen P, Li R, Tay WT, Zheng Y, Chew M, Consortium for Refractive E, Myopia, Burdon KP, Craig JE, Iyengar SK, Igo RP, Jr., Lass JH, Jr., Fuchs' Genetics Multi-Center Study G, Chew EY, Haller T, Mihailov E, Metspalu A, Wedenoja J, Simpson CL, Wojciechowski R, Hohn R, Mirshahi A, Zeller T, Pfeiffer N, Lackner KJ, Wellcome Trust Case Control C, Bettecken T, Meitinger T, Oexle K, Pirastu M, Portas L, Nag A, Williams KM, Yonova-Doing E, Klein R, Klein BE, Hosseini SM, Paterson AD, Diabetes C, Complications Trial/Epidemiology of Diabetes I, Complications Research G, Makela KM, Lehtimaki T, Kahonen M, Raitakari O, Yoshimura N, Matsuda F, Chen LJ, Pang CP, Yip SP, Yap MK, Meguro A, Mizuki N, Inoko H, Foster PJ, Zhao JH, Vithana E, Tai ES, Fan Q, Xu L, Campbell H, Fleck B, Rudan I, Aung T, Hofman A, Uitterlinden AG, Bencic G, Khor CC, Forward H, Parssinen O, Mitchell P, Rivadeneira F, Hewitt AW, Williams C, Oostra BA, Teo YY, Hammond CJ, Stambolian D, Mackey DA, Klaver CC, Wong TY, Saw SM, Baird PN. (2013)

93 (2); 264-77

Aggregate effects of intraocular pressure and cup-to-disc ratio genetic variants on glaucoma in a multiethnic Asian population.

Ophthalmology. – Tham YC, Liao J, Vithana EN, Khor CC, International Glaucoma Genetics Consortium, Teo YY, Tai ES, Wong TY, Aung T, Cheng CY. (2015)

122 (6); 1149-57

Assessment of iris surface features and their relationship with iris thickness in Asian eyes.

Ophthalmology. – Sidhartha E, Gupta P, Liao J, Tham YC, Cheung CY, He M, Wong TY, Aung T, Cheng CY. (2014)

121 (5); 1007-12

Ethnic differences of intraocular pressure and central corneal thickness: The Singapore epidemiology of eye diseases study.

Ophthalmology. – Chua J, Tham YC, Liao J, Zheng Y, Aung T, Wong TY, Cheng CY. (2014)

121 (10); 2013-22

Meta-analysis of genome-wide association studies in multiethnic Asians identifies two loci for age-related nuclear cataract.

Human Molecular Genetics. – Liao J, Su X, Chen P, Wang X, Xu L, Li X, Thean L, Tan C, Tan AG, Tay WT, Jun G, Zheng Y, Chew M, Wang YX, Tan QS, Barathi VA, Klein BE, Saw SM, Vithana EN, Tai ES, Iyengar SK, Mitchell P, Khor CC, Aung T, Wang JJ, Jonas JB, Teo YY‡, Wong TY‡, Cheng CY‡. [‡Co-last author] (2014)

23 (22); 6119-28