Directory

Directory

Ching Jianhong

Assistant Professor, Signature Research Programme in Cardiovascular & Metabolic Disorders

jianhong.ching@duke-nus.edu.sg

66013678

About

Professional

Research Interests

Teaching

Publications

Bio

Jianhong Ching, is an Assistant Professor at the Cardiovascular and Metabolic Disorders (CVMD) Programmed of Duke-NUS Medical School. He is a specialist in metabolomics studies using mass spectrometers and applying his techniques in metabolism research.

Jianhong graduated with a PhD in Life Sciences at NUS and joined CVMD as a postdoctoral fellow in 2011. During his career at Duke-NUS, he helped to set up Singapore’s first fee-for-service Metabolomics Core, which eventually became one of Singapore’s most prominent metabolomics research and service lab which researchers engage with. Jianhong was eventually promoted to Assistant Professor and heads the Metabolomics Core.

Education

Doctor of Philosophy

National University of Singapore, Singapore

Bachelor of Science (Biology) with Honours Class 1

National University of Singapore, Singapore

NUS Appointment(s)

Research Fellow

Duke-NUS, 08/2011 - 12/2014

Instructor

Duke-NUS, 01/2015 - 03/2017

Assistant Professor

Duke-NUS, Currently Active

Membership

Vice President

Singapore Society of Mass Spectrometry, Currently Active

Public Engagement Officer

Association of Official Analytical Chemists SEA Section, Currently Active

Member

Metabolomics Society, Currently Active

Research Interests

Jianhong has extensive experience in analytical chemistry and has applied metabolomics techniques to various metabolic disease related projects. His research interest is to develop new techniques to trace biochemical pathways for understanding of the kinetics of important disease biomarkers. This technique uses stable isotopes of carbon, nitrogen or hydrogen, which can be incorporated into the endogenous analytes of biological systems. These labelled analytes will be metabolised by the biological system, forming various labelled downstream intermediates that are monitored by a mass spectrometer. This method, known as fluxomics, provides kinetic information and traces specific biochemical pathways, an advantage over metabolomics which shows only static observations.

Jianhong is also interested in applying metabolomics to other fields, such as the gut microbiome, and novel foods. He is advising the Asian Microbiome Library (AMILI) as well as the Singapore Food Agency on the use of metabolomics in areas of microbiome research and food safety respectively.

Teaching

Lecturer, Duke-NUS, Clinical Applications of Metabolomics, Foundations of Precision Medicine (GMS6812), 2020 to present

Supervised 10 interns and undergraduate students from Singapore Polytechnic. 2014-2023

Guest Lecturer, Special Programme in Science, NUS: “Mentoring Students.” 2012- 2014

Guest Lecturer, University of Nottingham (Kuala Lumpur): “Concepts in Metabolomics”, March 2015

Mentored 5 students conducting final year projects (Departments of Pharmacy and Pharmacology). 2008-2010. One project won a poster presentation award in the 6th American Association of Pharmaceutical Scientist-National University of Singapore Student Chapter Scientific Symposium, and was nominated for the Outstanding Undergraduate Researcher Prize. Another project was presented in the Universitas 21 Undergraduate Research Conference.

Senior student mentor, Special Programme in Science, NUS, Aug 2005 -Nov 2010. Mentored/Co-mentored more than 10 multidisciplinary undergraduate research projects, also help guide junior mentors in teaching. Also involved in lesson coordination.

Publications

Gut-brain axis through the lens of gut microbiota and their relationships with Alzheimer's disease pathology: Review and recommendations.

Mechanisms of ageing and development – L Krishaa; Ng Ted Kheng Siang; Wee Hai Ning; Ching Jianhong (2023)

211 111787-111787

The Kynurenine Pathway in Acute Kidney Injury and Chronic Kidney Disease.

American journal of nephrology – Wee Hai Ning; Liu Jian-Jun; Ching Jianhong*; Kovalik Jean-Paul; Lim Su Chi *Corresponding author (2021)

52 (10-11); 771-787

Urine Tricarboxylic Acid Cycle Metabolites Predict Progressive Chronic Kidney Disease in Type 2 Diabetes.

The Journal of clinical endocrinology and metabolism – Liu Jian-Jun; Liu Sylvia; Gurung Resham L; Ching Jianhong; Kovalik Jean-Paul; Tan Tsze Yin; Lim Su Chi (2018)

103 (12); 4357-4364

Urine tricarboxylic acid cycle metabolites and risk of end stage kidney disease in patients with type 2 diabetes.

The Journal of clinical endocrinology and metabolism – Liu Jian-Jun; Liu Sylvia; Zheng Huili; Lee Janus; Gurung Resham L; Chan Clara; Lee Lye Siang; Ang Keven; Ching Jianhong; Kovalik Jean-Paul; Tavintharan Subramaniam; Sum Chee Fang; Sharma Kumar; Coffman Thomas M; Lim Su Chi (2024)

Plasma Tryptophan-Kynurenine Pathway Metabolites and Risk for Progression to End-Stage Kidney Disease in Patients With Type 2 Diabetes.

Diabetes care – Liu Jian-Jun; Ching Jianhong*; Wee Hai Ning; Liu Sylvia; Gurung Resham L; Lee Janus; M Yiamunaa; Zheng Huili; Lee Lye Siang; Ang Keven; Shao Yi Ming; Kovalik Jean-Paul; Subramaniam Tavintharan; Sum Chee Fang; Sharma Kumar; Kestenbaum Bryan R; Lim Su Chi *Co-first author (2023)

46 (12); 2223-2231

Lipidomics Workflow for Analyzing Lipid Profiles Using Multiple Reaction Monitoring (MRM) in Liver Homogenate of Mice with Non-alcoholic Steatohepatitis (NASH).

Bio-protocol – Wee Hai Ning; Lee Lye Siang; Han Sharon Hong Yu; Zhou Jin; Yen Paul Michael; Ching Jianhong (2023)

13 (13);

A chemical biology approach reveals a dependency of glioblastoma on biotin distribution.

Science advances – Yoon Jeehyun; Grinchuk Oleg V; Kannan Srinivasaraghavan; Ang Melgious Jin Yan; Li Zhenglin; Tay Emmy Xue Yun; Lok Ker Zhing; Lee Bernice Woon Li; Chuah You Heng; Chia Kimberly; Tirado Magallanes Roberto; Liu Chenfei; Zhao Haonan; Hor Jin Hui; Lim Jhin Jieh; Benoukraf Touati; Toh Tan Boon; Chow Edward Kai-Hua; Kovalik Jean-Paul; Ching Jianhong; Ng Shi-Yan; Koh Ming Joo; Liu Xiaogang; Verma Chandra Shekhar; Ong Derrick Sek Tong (2021)

7 (36);

Abnormal lactate metabolism is linked to albuminuria and kidney injury in diabetic nephropathy.

Kidney international – Azushima Kengo; Kovalik Jean-Paul; Yamaji Takahiro; Ching Jianhong; Chng Tze Wei; Guo Jing; Liu Jian-Jun; Nguyen Mien; Sakban Rashidah Binte; George Simi E; Tan Puay Hoon; Lim Su Chi; Gurley Susan B; Coffman Thomas M (2023)

104 (6); 1135-1149

Plasma Acylcarnitines as Metabolic Signatures of Declining Health-Related Quality of Life Measure in Community-Dwelling Older Adults: A Combined Cross-sectional and Longitudinal Pilot Study.

The journals of gerontology. Series A, Biological sciences and medical sciences – Ng Ted Kheng Siang; Wee Hai Ning; Ching Jianhong; Kovalik Jean-Paul; Chan Angelique W; Matchar David Bruce (2024)

79 (3);

Novel metabolomics markers are associated with pre-clinical decline in hand grip strength in community-dwelling older adults.

Mechanisms of ageing and development – Ng Ted Kheng Siang; Kovalik Jean-Paul; Ching Jianhong; Chan Angelique W; Matchar David Bruce (2021)

193

Profiling of Plasma Metabolites Suggests Altered Mitochondrial Fuel Usage and Remodeling of Sphingolipid Metabolism in Individuals With Type 2 Diabetes and Kidney Disease.

Kidney international reports – Liu Jian-Jun; Ghosh Sujoy; Kovalik Jean-Paul; Ching Jianhong; Choi Hyung Won; Tavintharan Subramaniam; Ong Choon Nam; Sum Chee Fang; Summers Scott A; Tai E Shyong; Lim Su Chi (2017)

2 (3); 470-480

Thyroid Hormone Decreases Hepatic Steatosis, Inflammation, and Fibrosis in a Dietary Mouse Model of Nonalcoholic Steatohepatitis.

Thyroid : official journal of the American Thyroid Association – Zhou Jin; Tripathi Madhulika; Ho Jia Pei; Widjaja Anissa Anindya; Shekeran Shamini Guna; Camat Macalinao Dominique; James Anne; Wu Yajun; Ching Jianhong; Kovalik Jean-Paul; Lim Kiat-Hon; Cook Stuart Alexander; Bay Boon-Huat; Singh Brijesh Kumar; Yen Paul Michael (2022)

32 (6); 725-738

Amino acid profile of skeletal muscle loss in type 2 diabetes: Results from a 7-year longitudinal study in asians.

Diabetes research and clinical practice – Low Serena; Wang Jiexun; Moh Angela; Ang Su Fen; Ang Keven; Shao Yi-Ming; Ching Jianhong; Wee Hai Ning; Lee Lye Siang; Kovalik Jean-Paul; Tang Wern Ee; Lim Ziliang; Subramaniam Tavintharan; Sum Chee Fang; Lim Su Chi (2022)

186 109803-N>A.

Exacerbation of cardiovascular ageing by diabetes mellitus and its associations with acyl-carnitines.

Aging – Gao Fei; Kovalik Jean-Paul; Zhao Xiaodan; Chow Vivian Jm; Chew Hannah; Teo Louis Ly; Tan Ru San; Leng Shuang; Ewe See Hooi; Tan Hong Chang; Tan Tsze Yin; Lee Lye Siang; Ching Jianhong; Keng Bryan Mh; Zhong Liang; Koh Woon-Puay; Koh Angela S (2021)

13 (11); 14785-14805

Serum acylcarnitines and amino acids and risk of type 2 diabetes in a multiethnic Asian population.

BMJ open diabetes research & care – Gunther Samuel H; Khoo Chin Meng; Tai E-Shyong; Sim Xueling; Kovalik Jean-Paul; Ching Jianhong; Lee Jeannette J; van Dam Rob M (2020)

8 (1);

Plasma Ceramides as Prognostic Biomarkers and Their Arterial and Myocardial Tissue Correlates in Acute Myocardial Infarction.

JACC. Basic to translational science – de Carvalho Leonardo P; Tan Sock Hwee; Ow Ghim-Siong; Tang Zhiqun; Ching Jianhong; Kovalik Jean-Paul; Poh Sock Cheng; Chin Chee-Tang; Richards A Mark; Martinez Eliana C; Troughton Richard W; Fong Alan Yean-Yip; Yan Bryan P; Seneviratna Aruni; Sorokin Vitaly; Summers Scott A; Kuznetsov Vladimir A; Chan Mark Y (2018)

3 (2); 163-175

Macrophage VLDLR mediates obesity-induced insulin resistance with adipose tissue inflammation.

Nature communications – Shin Kyung Cheul; Hwang Injae; Choe Sung Sik; Park Jeu; Ji Yul; Kim Jong In; Lee Gha Young; Choi Sung Hee; Ching Jianhong; Kovalik Jean-Paul; Kim Jae Bum (2017)

8 (1);

A Role for Ceramides, but Not Sphingomyelins, as Antagonists of Insulin Signaling and Mitochondrial Metabolism in C2C12 Myotubes.

The Journal of biological chemistry – Park Min; Kaddai Vincent; Ching Jianhong; Fridianto Kevin T; Sieli Ryan J; Sugii Shigeki; Summers Scott A (2016)

291 (46); 23978-23988

CerS2 Haploinsufficiency Inhibits β-Oxidation and Confers Susceptibility to Diet-Induced Steatohepatitis and Insulin Resistance.

Cell metabolism – Raichur Suryaprakash; Wang Siew Tein; Chan Puck Wee; Li Ying; Ching Jianhong; Chaurasia Bhagirath; Dogra Shaillay; Öhman Miina K; Takeda Kosuke; Sugii Shigeki; Pewzner-Jung Yael; Futerman Anthony H; Summers Scott A (2014)

20 (5);

Ceramides and glucosylceramides are independent antagonists of insulin signaling.

The Journal of biological chemistry – Chavez Jose A; Siddique M Mobin; Wang Siew Tein; Ching Jianhong; Shayman James A; Summers Scott A (2014)

289 (2); 723-34

Directory

Bio

Education

Doctor of Philosophy

Bachelor of Science (Biology) with Honours Class 1

NUS Appointment(s)

Research Fellow

Instructor

Assistant Professor

Membership

Vice President

Public Engagement Officer

Member

Research Interests

Teaching

Publications

Gut-brain axis through the lens of gut microbiota and their relationships with Alzheimer's disease pathology: Review and recommendations.

The Kynurenine Pathway in Acute Kidney Injury and Chronic Kidney Disease.

Urine Tricarboxylic Acid Cycle Metabolites Predict Progressive Chronic Kidney Disease in Type 2 Diabetes.

Urine tricarboxylic acid cycle metabolites and risk of end stage kidney disease in patients with type 2 diabetes.

Plasma Tryptophan-Kynurenine Pathway Metabolites and Risk for Progression to End-Stage Kidney Disease in Patients With Type 2 Diabetes.

Lipidomics Workflow for Analyzing Lipid Profiles Using Multiple Reaction Monitoring (MRM) in Liver Homogenate of Mice with Non-alcoholic Steatohepatitis (NASH).

A chemical biology approach reveals a dependency of glioblastoma on biotin distribution.

Abnormal lactate metabolism is linked to albuminuria and kidney injury in diabetic nephropathy.

Plasma Acylcarnitines as Metabolic Signatures of Declining Health-Related Quality of Life Measure in Community-Dwelling Older Adults: A Combined Cross-sectional and Longitudinal Pilot Study.

Novel metabolomics markers are associated with pre-clinical decline in hand grip strength in community-dwelling older adults.

Profiling of Plasma Metabolites Suggests Altered Mitochondrial Fuel Usage and Remodeling of Sphingolipid Metabolism in Individuals With Type 2 Diabetes and Kidney Disease.

Thyroid Hormone Decreases Hepatic Steatosis, Inflammation, and Fibrosis in a Dietary Mouse Model of Nonalcoholic Steatohepatitis.

Amino acid profile of skeletal muscle loss in type 2 diabetes: Results from a 7-year longitudinal study in asians.

Exacerbation of cardiovascular ageing by diabetes mellitus and its associations with acyl-carnitines.

Serum acylcarnitines and amino acids and risk of type 2 diabetes in a multiethnic Asian population.

Plasma Ceramides as Prognostic Biomarkers and Their Arterial and Myocardial Tissue Correlates in Acute Myocardial Infarction.

Macrophage VLDLR mediates obesity-induced insulin resistance with adipose tissue inflammation.

A Role for Ceramides, but Not Sphingomyelins, as Antagonists of Insulin Signaling and Mitochondrial Metabolism in C2C12 Myotubes.

CerS2 Haploinsufficiency Inhibits β-Oxidation and Confers Susceptibility to Diet-Induced Steatohepatitis and Insulin Resistance.

Ceramides and glucosylceramides are independent antagonists of insulin signaling.

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