ABOUT THE LECTURE
G protein-coupled receptor (GPCR) kinases (GRKs) are crucial regulators of signaling in the cardiomyocyte regulating such GPCRs as the β-adrenergic and angiotensin II receptors. GRK2 and GRK5 are the major GRKs expressed in the heart and both have been shown to be up-regulated in the failing human heart and associated with heart failure development. Pour lab has spent the last three decades studying these two kinases and their canonical and non-canonical roles in cardiac injury and repair and how they are emerging as novel therapeutic targets in heart failure. Our latest published and non-published data on both of these GRKs will be presented in this seminar.
HOST
Prof Wang Yibin
Director
Cardiovascular and Metabolic Disorders Programme
Duke-NUS Medical School
VENUE
Duke-NUS Medical School
Amphitheatre, Level 2
CONTACT PERSON
Ms Serene Wie (serene.wie@duke-nus.edu.sg)
Duke-NUS Research Affairs Department
Date and Time
02 Oct 2024 @ 12:00 - 02 Oct 2024 @ 13:00
Speaker
Dr. Walter J. Koch, PhD
Professor
Departments of Surgery (Cardiovascular and Thoracic Surgery) and Medicine (Cardiology)
Cardiovascular Research Center
Duke University School of Medicine
ABOUT THE SPEAKER
Dr Walter J. Koch is currently a tenured full-professor at Duke University School of Medicine in the Departments of Surgery and Medicine after serving as the Chair of Pharmacology at Temple University for 12 years. Dr. Koch received his PhD in Pharmacology and Cell Biophysics in 1990 from the University of Cincinnati College of Medicine in the lab of Dr. Arnold Schwartz. He went to Duke University Medical Center and the Howard Hughes Medical Institute as a postdoctoral fellow (1990-1994) in the lab of Dr. Robert J. Lefkowitz (Nobel Prize in Chemistry, 2012). The Koch lab studies molecular mechanisms for cardiac injury and repair focusing on G protein-coupled receptor kinase (GRK) signaling in the heart and also development of novel molecular strategies to repair the heart.