Directory

Keystone travel award

Keystone Symposia,2019

Young Investigator Award in Basic/Translational Research

Singapore General Hospital (SGH),2019

Best oral presentation @Dunes Symposium

Duke-NUS Medical School,2017

PhD Research Scholarship

Nanyang Technological University,2008

IL-11 is a crucial determinant of cardiovascular fibrosis.

Nature – Schafer Sebastian*; Viswanathan Sivakumar*; Widjaja Anissa A*; Lim Wei-Wen; Moreno-Moral Aida; DeLaughter Daniel M; Ng Benjamin; Patone Giannino; Chow Kingsley; Khin Ester; Tan Jessie; Chothani Sonia P; Ye Lei; Rackham Owen J L; Ko Nicole S J; Sahib Norliza E; Pua Chee Jian; Zhen Nicole T G; Xie Chen; Wang Mao; Maatz Henrike; Lim Shiqi; Saar Kathrin; Blachut Susanne; Petretto Enrico; Schmidt Sabine; Putoczki Tracy; Guimarães-Camboa Nuno; Wakimoto Hiroko; van Heesch Sebastiaan; Sigmundsson Kristmundur; Lim See L; Soon Jia L; Chao Victor T T; Chua Yeow L; Tan Teing E; Evans Sylvia M; Loh Yee J; Jamal Muhammad H; Ong Kim K; Chua Kim C; Ong Boon-Hean; Chakaramakkil Mathew J; Seidman Jonathan G; Seidman Christine E; Hubner Norbert; Sin Kenny Y K; Cook Stuart A.  *Joint first author (2017)

552 (7683); 110-115

Inhibiting Interleukin 11 Signaling Reduces Hepatocyte Death and Liver Fibrosis, Inflammation, and Steatosis in Mouse Models of Nonalcoholic Steatohepatitis.

Gastroenterology – Widjaja Anissa A; Singh Brijesh K; Adami Eleonora; Viswanathan Sivakumar; Dong Jinrui; D'Agostino Giuseppe A; Ng Benjamin; Lim Wei Wen; Tan Jessie; Paleja Bhairav S; Tripathi Madhulika; Lim Sze Yun; Shekeran Shamini Guna; Chothani Sonia P; Rabes Anne; Sombetzki Martina; Bruinstroop Eveline; Min Lio Pei; Sinha Rohit A; Albani Salvatore; Yen Paul M; Schafer Sebastian; Cook Stuart A (2019)

157 (3); 777-792.e14

Redefining IL11 as a regeneration-limiting hepatotoxin and therapeutic target in acetaminophen-induced liver injury.

Science translational medicine – Widjaja Anissa A*; Dong Jinrui; Adami Eleonora; Viswanathan Sivakumar; Ng Benjamin; Pakkiri Leroy S; Chothani Sonia P; Singh Brijesh K; Lim Wei Wen; Zhou Jin; Shekeran Shamini G; Tan Jessie; Lim Sze Yun; Goh Joyce; Wang Mao; Holgate Robert; Hearn Arron; Felkin Leanne E; Yen Paul M; Dear James W; Drum Chester L; Schafer Sebastian; Cook Stuart A.  *First and corresponding author (2021)

13 (597);

Hepatocyte-specific IL11 cis-signaling drives lipotoxicity and underlies the transition from NAFLD to NASH.

Nature communications – Dong Jinrui; Viswanathan Sivakumar; Adami Eleonora; Singh Brijesh K; Chothani Sonia P; Ng Benjamin; Lim Wei Wen; Zhou Jin; Tripathi Madhulika; Ko Nicole S J; Shekeran Shamini G; Tan Jessie; Lim Sze Yun; Wang Mao; Lio Pei Min; Yen Paul M; Schafer Sebastian; Cook Stuart A; Widjaja Anissa A (2021)

12 (1);

Targeting endogenous kidney regeneration using anti-IL11 therapy in acute and chronic models of kidney disease.

Nature communications – Widjaja Anissa A*; Viswanathan Sivakumar; Shekeran Shamini G; Adami Eleonora; Lim Wei-Wen; Chothani Sonia; Tan Jessie; Goh Joyce Wei Ting; Chen Hui Mei; Lim Sze Yun; Boustany-Kari Carine M; Hawkins Julie; Petretto Enrico; Hübner Norbert; Schafer Sebastian; Coffman Thomas M; Cook Stuart A.  *First, corresponding, and joint senior author. This article has been recognized as one of the Top 25 Health Science Articles in Nature Communications 2022 (2022)

13 (1);

A Neutralizing IL-11 Antibody Improves Renal Function and Increases Lifespan in a Mouse Model of Alport Syndrome.

Journal of the American Society of Nephrology : JASN – Widjaja Anissa A*; Shekeran Shamini G; Adami Eleonora; Ting Joyce G Wei; Tan Jessie; Viswanathan Sivakumar; Lim Sze Yun; Tan Puay Hoon; Hübner Norbert; Coffman Thomas; Cook Stuart A.  *First and corresponding author (2022)

33 (4); 718-730

IL11 Stimulates IL33 Expression and Proinflammatory Fibroblast Activation across Tissues.

International journal of molecular sciences – Widjaja Anissa A*; Chothani Sonia; Viswanathan Sivakumar; Goh Joyce Wei Ting; Lim Wei-Wen; Cook Stuart A.  *First and corresponding author (2022)

23 (16);

Molecular Dissection of Pro-Fibrotic IL11 Signaling in Cardiac and Pulmonary Fibroblasts.

Frontiers in molecular biosciences – Widjaja Anissa A*; Viswanathan Sivakumar; Jinrui Dong; Singh Brijesh K; Tan Jessie; Wei Ting Joyce Goh; Lamb David; Shekeran Shamini G; George Benjamin L; Schafer Sebastian; Carling David; Adami Eleonora; Cook Stuart A.  *First and corresponding author (2021)

8

IL11 stimulates ERK/P90RSK to inhibit LKB1/AMPK and activate mTOR initiating a mesenchymal program in stromal, epithelial, and cancer cells.

iScience – Widjaja Anissa A*; Viswanathan Sivakumar; Wei Ting Joyce Goh; Tan Jessie; Shekeran Shamini G; Carling David; Lim Wei-Wen; Cook Stuart A.  *First and corresponding author (2022)

25 (8);

The Translational Landscape of the Human Heart.

Cell – van Heesch Sebastiaan; Witte Franziska; Schneider-Lunitz Valentin; Schulz Jana F; Adami Eleonora; Faber Allison B; Kirchner Marieluise; Maatz Henrike; Blachut Susanne; Sandmann Clara-Louisa; Kanda Masatoshi; Worth Catherine L; Schafer Sebastian; Calviello Lorenzo; Merriott Rhys; Patone Giannino; Hummel Oliver; Wyler Emanuel; Obermayer Benedikt; Mücke Michael B; Lindberg Eric L; Trnka Franziska; Memczak Sebastian; Schilling Marcel; Felkin Leanne E; Barton Paul J R; Quaife Nicholas M; Vanezis Konstantinos; Diecke Sebastian; Mukai Masaya; Mah Nancy; Oh Su-Jun; Kurtz Andreas; Schramm Christoph; Schwinge Dorothee; Sebode Marcial; Harakalova Magdalena; Asselbergs Folkert W; Vink Aryan; de Weger Roel A; Viswanathan Sivakumar; Widjaja Anissa A; Gärtner-Rommel Anna; Milting Hendrik; Dos Remedios Cris; Knosalla Christoph; Mertins Philipp; Landthaler Markus; Vingron Martin; Linke Wolfgang A; Seidman Jonathan G; Seidman Christine E; Rajewsky Nikolaus; Ohler Uwe; Cook Stuart A; Hubner Norbert (2019)

178 (1); 242-260.e29

Interleukin-11 is a therapeutic target in idiopathic pulmonary fibrosis.

Science translational medicine – Ng Benjamin; Dong Jinrui; D'Agostino Giuseppe; Viswanathan Sivakumar; Widjaja Anissa A; Lim Wei-Wen; Ko Nicole S J; Tan Jessie; Chothani Sonia P; Huang Benjamin; Xie Chen; Pua Chee Jian; Chacko Ann-Marie; Guimarães-Camboa Nuno; Evans Sylvia M; Byrne Adam J; Maher Toby M; Liang Jiurong; Jiang Dianhua; Noble Paul W; Schafer Sebastian; Cook Stuart A (2019)

11 (511);

Widespread Translational Control of Fibrosis in the Human Heart by RNA-Binding Proteins.

Circulation – Chothani Sonia; Schäfer Sebastian; Adami Eleonora; Viswanathan Sivakumar; Widjaja Anissa A; Langley Sarah R; Tan Jessie; Wang Mao; Quaife Nicholas M; Jian Pua Chee; D'Agostino Giuseppe; Guna Shekeran Shamini; George Benjamin L; Lim Stella; Yiqun Cao Elaine; van Heesch Sebastiaan; Witte Franziska; Felkin Leanne E; Christodoulou Eleni G; Dong Jinrui; Blachut Susanne; Patone Giannino; Barton Paul J R; Hubner Norbert; Cook Stuart A; Rackham Owen J L (2019)

140 (11); 937-951

Different roles of interleukin 6 and interleukin 11 in the liver: implications for therapy.

Human vaccines & immunotherapeutics – Widjaja Anissa A; Chothani Sonia P; Cook Stuart A (2020)

16 (10); 2357-2362

Similarities and differences between IL11 and IL11RA1 knockout mice for lung fibro-inflammation, fertility and craniosynostosis.

Scientific reports – Ng Benjamin*; Widjaja Anissa A*; Viswanathan Sivakumar; Dong Jinrui; Chothani Sonia P; Lim Stella; Shekeran Shamini G; Tan Jessie; McGregor Narelle E; Walker Emma C; Sims Natalie A; Schafer Sebastian; Cook Stuart A.  *Joint first author (2021)

11 (1);

Interleukin-11 drives human and mouse alcohol-related liver disease.

Gut – Effenberger Maria; Widjaja Anissa A; Grabherr Felix; Schaefer Benedikt; Grander Christoph; Mayr Lisa; Schwaerzler Julian; Enrich Barbara; Moser Patrizia; Fink Julia; Pedrini Alisa; Jaschke Nikolai; Kirchmair Alexander; Pfister Alexandra; Hausmann Bela; Bale Reto; Putzer Daniel; Zoller Heinz; Schafer Sebastian; Pjevac Petra; Trajanoski Zlatko; Oberhuber Georg; Adolph Timon; Cook Stuart; Tilg Herbert (2023)

72 (1); 168-179

Transgenic interleukin 11 expression causes cross-tissue fibro-inflammation and an inflammatory bowel phenotype in mice.

PloS one – Lim Wei-Wen; Ng Benjamin; Widjaja Anissa; Xie Chen; Su Liping; Ko Nicole; Lim Sze-Yun; Kwek Xiu-Yi; Lim Stella; Cook Stuart Alexander; Schafer Sebastian (2020)

15 (1);

Interleukin-11 is important for vascular smooth muscle phenotypic switching and aortic inflammation, fibrosis and remodeling in mouse models.

Scientific reports – Lim Wei-Wen; Corden Ben; Ng Benjamin; Vanezis Konstantinos; D'Agostino Giuseppe; Widjaja Anissa A; Song Wei-Hua; Xie Chen; Su Liping; Kwek Xiu-Yi; Tee Nicole G Z; Dong Jinrui; Ko Nicole S J; Wang Mao; Pua Chee Jian; Jamal Muhammad H; Soh Beeyong; Viswanathan Sivakumar; Schafer Sebastian; Cook Stuart A (2020)

10 (1);

IL11 is elevated in systemic sclerosis and IL11-dependent ERK signalling underlies TGFβ-mediated activation of dermal fibroblasts.

Rheumatology (Oxford, England) – Adami Eleonora; Viswanathan Sivakumar; Widjaja Anissa A; Ng Benjamin; Chothani Sonia; Zhihao Nevin; Tan Jessie; Lio Pei Min; George Benjamin L; Altunoglu Umut; Ghosh Kakaly; Paleja Bhairav S; Schafer Sebastian; Reversade Bruno; Albani Salvatore; Ling Andrea Low Hsiu; O'Reilly Steven; Cook Stuart A (2021)

60 (12); 5820-5826

Vitamin B and folate decrease inflammation and fibrosis in NASH by preventing syntaxin 17 homocysteinylation.

Journal of hepatology – Tripathi Madhulika; Singh Brijesh Kumar; Zhou Jin; Tikno Keziah; Widjaja Anissa; Sandireddy Reddemma; Arul Kabilesh; Abdul Ghani Siti Aishah Binte; Bee George Goh Boon; Wong Kiraely Adam; Pei Ho Jia; Shekeran Shamini Guna; Sinha Rohit Anthony; Singh Manvendra K; Cook Stuart Alexander; Suzuki Ayako; Lim Teegan Reina; Cheah Chang-Chuen; Wang Jue; Xiao Rui-Ping; Zhang Xiuqing; Chow Pierce Kah Hoe; Yen Paul Michael (2022)

77 (5); 1246-1255

Thyroid Hormone Decreases Hepatic Steatosis, Inflammation, and Fibrosis in a Dietary Mouse Model of Nonalcoholic Steatohepatitis.

Thyroid : official journal of the American Thyroid Association – Zhou Jin; Tripathi Madhulika; Ho Jia Pei; Widjaja Anissa Anindya; Shekeran Shamini Guna; Camat Macalinao Dominique; James Anne; Wu Yajun; Ching Jianhong; Kovalik Jean-Paul; Lim Kiat-Hon; Cook Stuart Alexander; Bay Boon-Huat; Singh Brijesh Kumar; Yen Paul Michael (2022)

32 (6); 725-738