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David Lawrence Silver

Professor, Signature Research Programme in Cardiovascular & Metabolic Disorders

Deputy Programme Director, Signature Research Programme in Cardiovascular & Metabolic Disorders

Duke-NUS Medical School

Bio

Dr. Silver is Professor and Deputy Director in the Signature Research Program in Cardiovascular & Metabolic Disorders at the Duke-NUS Medical School. Dr. Silver obtained his Ph.D. in Genetics from Michigan State University, and postdoctoral training at Columbia University specializing in biochemistry and lipid metabolism. His long-standing research interests are in the areas of lipid storage, transport and metabolism and has a translational focus in applying his laboratory’s discoveries to the treatment of human diseases. Dr. Silver’s laboratory is supported through competitive grants from the National Medical Research Council, Ministry of Education and National Research Foundation, is multidisciplinary utilizing biochemistry, structural biology, molecular genetics in mice and humans, and molecular and cellular biology. Dr. Silver’s notable discoveries include the FITM family of endoplasmic reticulum proteins and Mfsd2a, a lysolipid transporter critical for human brain growth and Spns1, a lysosomal lysolipid transporter important for phospholipid salvage and lysosomal function. His laboratory’s research has been published in scientific journals such as Nature, Nature Genetics, Journal of Clinical Investigation, and Proceedings of the National Academy of Sciences, USA.

Education

Doctor of Philosophy

Michigan State University, United States

Bachelor of Science in Biology

Pennsylvania State University, United States

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