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Derrick Chan Wei Shih

Associate Professor, Appointments & Development Department

Duke-NUS Medical School

Bio

I am a Senior Consultant of Paediatric Neurology at KK Women’s and Children’s Hospital. I graduated from Nottingham University with Bachelor’s in Medical Science (1996) and Bachelor of Medicine and Surgery (1998), passed my Membership exams for the Royal College of Paediatrics and Child Health in 2002 and obtained Specialist Accreditation in Paediatric Medicine in 2007. I trained in Paediatric EEG at Great Ormond Children's Hospital in London, UK and the Royal Children’s Hospital in Melbourne, followed by a 15-month Clinical Fellowship in Paediatric Epilepsy at the Hospital for Sick Children in Toronto. I obtained certification in Clinical Neurophysiology from the Canadian Society of Clinical Neurophysiology in 2008 and received my Master’s Degree in Clinical Investigation in 2011. 

I set up the comprehensive epilepsy programme at KKH, including the epilepsy monitoring unit, ketogenic diet and complicated epilepsy clinics, vagus nerve stimulator implantation programme and epilepsy surgery programme. I am driving the paediatric epilepsy research programme and have established collaborations in Paediatric Epilepsy with Duke Durham. I have led the Paediatric Neurology team to clinical, research and educational excellence, expanding the team and establishing expertise in vital areas of paediatric neurology. Under my mentorship, this team spearheads in clinical care, research, education and medical informatics. I am an instructor and examiner for the ASEAN Epilepsy Academy (ASEPA) Electro-encephalography exam and lecture regionally on paediatric neurology, epilepsy and neurophysiology. I have raised Paediatric Neurology at KKH to world-class standards, with trainees applying from the ASEAN region, Africa, the Middle East and Europe and recognition from Australia and the United Kingdom as a training centre. I mentored the KKH/Singhealth team for the 2017 Health Service Development Programme grant “PINS: Paediatric Integrated Neurorehabilitation Service – Integrating tertiary and community care”, which has been selected for funding in 2018

I obtained a research grant from BMRC in 2008 for SGD $1.2 million to develop a video analytics seizure detection device and was awarded further BMRC grants in 2012 and 2014. I have registered intellectual property and technology declarations. I received a Singhealth-NHIC grant in 2016 and my computer vision prototype is completing clinical trials with a view to licensing and commercialization. I obtained NMRC block funding for work on HLA-B*1502 alleles in children with carbamazepine hypersensitivity in 2008. I published in the Archives of Diseases of Childhood and implemented my work by facilitating one of 2 national HLA-B*1502 testing centres at KKH, as well as a faster turnaround HLA-B*1502 testing service together with A/Prof Law Hai Yang at KKH. I developed a seamless automated logic for HLA-B*1502 results checking during carbamazepine prescription in Sunrise Clinical Manager, which has been implemented throughout Singhealth by IHIS. I was awarded the Duke-NUS Bridging Fund for my 2017 NMRC HSRG submission and have been awarded funding for my NMRC HSRG grant “HSRG-OC17Jun: Cost containment in pharmacogenomic testing, identifying obstacles to implementation of pharmacogenomics and impact on anticonvulsant prescription patterns”. I set up the Paediatric Autoimmune Epilepsy, Demyelination & Encephalitis Study (PAEDES) under the KKH NMRC Centre grant and have conducted translational research in close collaboration with Prof Salvatore Albani and the Singhealth/Duke-NUS Translational Immunology Institute. Our work has been presented at national and international conferences and we are preparing manuscripts for publication in high impact journals. I was awarded the NMRC Clinician Scientist Award - Investigator (CSA-INV) in May 2020 for " Th17 and natural killer cells as modulators of the central nervous system in childhood epilepsy"

In Medical Technology and in my role as Deputy Director (Education) for the Singhealth MedTech Office, I organized the Singhealth Clinician Innovation lecture series in 2017-2018. I proposed, set up and ran the MedTech Clinical Innovation sessions in the NUS Masters Degree in Clinical Investigation in 2017, which have become a regular part of the MCI, and am developing the Clinician Innovator track in Singhealth with A/Prof Henry Ho. I have led the SingHealth Medical Technology Office (MTO) clinical innovation group developing SG-Inspire (SinGapore Invasive/non-invasive support for effective respiration), a rapid ventilator prototyping team for COVID-19 pandemic and regional healthcare needs. This project has been designed and innovated locally and is applying for Health Service Authority expedited approval to serve the national and regional needs.

 As former Vice-Chair (Research) for the Paediatrics ACP, I have championed excellence in clinical and translational research with an ethical and objective ethos. I have driven Paediatrics ACP and KKH research administration to reduce bureaucracy and facilitate clinician researchers in their research. I have guided the Paediatrics ACP internal grant system to improve governance and drive a research culture that develops skills to compete for national-level grants. I have supported multiple paediatric clinician-researchers along their career in obtaining their Singhealth NCSS and NMRC CS-NIG and CS-TA awards and support and assist senior clinician-scientists who call the Paediatrics ACP their academic home.

Education

Member, Royal Coll of Paediatrics & Child Health

Royal College of Paediatrics and Child Health, United Kingdom

Bachelor of Medicine, Bachelor of Surgery

University of Nottingham, United Kingdom

Bachelor of Medical Science

University of Nottingham, United Kingdom

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