Directory

My research is highly collaborative and involves working with clinicians, veterinarians, epidemiologists, ecologists, ornithologists, mathematicians and computer scientists to integrate diverse experimental approaches. My work's unifying theme is understanding the underlying processes of disease emergence and the interaction between host and pathogen. We conduct research combining ideas from different fields, including evolutionary genetics, virology, ecology, and infectious disease epidemiology. My team performs human and animal disease surveillance, isolates and characterizes the pathogen, and then conducts large-scale analyses to generate hypotheses that we test using tissue culture and animal models. I work primarily on influenza and coronaviruses but also study many other respiratory viruses and emerging infectious diseases. Another vital part of my work is engaging with scientists across Asia to assist in developing local research and technical capacity for disease detection, prevention and control.

Visit the Laboratory of Virus Evolution here: www.gavinsmith.io

Advancing pathogen genomics in resource-limited settings.

Cell genomics – Pronyk Paul Michael; de Alwis Ruklanthi; Rockett Rebecca; Basile Kerri; Boucher Yann Felix; Pang Vincent; Sessions October; Getchell Marya; Golubchik Tanya; Lam Connie; Lin Raymond; Mak Tze-Minn; Marais Ben; Twee-Hee Ong Rick; Clapham Hannah Eleanor; Wang Linfa; Cahyorini Yorin; Polotan Francisco Gerardo M; Rukminiati Yuni; Sim Eby; Suster Carl; Smith Gavin J D; Sintchenko Vitali (2023)

3 (12);

The genomic landscape of swine influenza A viruses in Southeast Asia

PNAS – Zeller MA, Ma J, Wong FY, Tum S, Hidano A, Holt H, Chhay T, San S, Koeut D, Seng B, Chao S, Ng GGK, Yan Z, Chou M, Rudge JW, Smith GJD, Su YCF  (2023)

Genomic epidemiology of SARS-CoV-2 in Cambodia, January 2020 to February 2021

Virus Evolution 9: 1-10 – Su, YCF, Ma JZJ, Ou TP, Pum L, Krang S, Raftery P, Kinzer MH, Bohl J, Ieng V, Kab V, Patel S, Sar B, Wong FY, Jayakumar J, Horm VS, Boukli N, Yann S, Troupin C, Heang V, Garcia-Rivera JA, Sengdoeurn Y, Heng S, Lay S, Chea S, Darapheak C, Savuth C, Khalakdina A, Ly S, Baril L, Manning JE, Simone-Loriere E, Duong V, Dussart P, Sovann L, Smith GJD, Karlsson EA (2023)

9 (1);

Cencurut virus: A novel Orthonairovirus from Asian house shrews (Suncus murinus) in Singapore.

One Health 16:100529 – Low DHW, Ch’ng L, Su YCF, Linster M, Zhang R, Kwak ML, Borthwick SA, Hitch A, Smith GJD, Mendenhall IH (2023)

Betacoronaviruses SARS-CoV-2 and HCoV-OC43 infections in IGROV-1 cell line require aryl hydrocarbon receptor.

Emerging microbes & infections – Yousefi Meisam; Lee Wai Suet; Chan Wharton O Y; He Wei; Mah Marcus G; Yong Cythia Lingli; Deerain Joshua M; Wang Lijin; Arcinas Camille; Yan Biaoguo; Tan Dewei; Sia Wan Rong; Gamage Akshamal M; Yang Jinxuan; Hsu Alan Chen-Yu; Li Shang; Linster Martin; Yang Xinglou; Ghosh Sujoy; Anderson Danielle E; Smith Gavin J D; Tan Chee Wah; Wang Lin-Fa; Ooi Yaw Shin (2023)

12 (2);

Ancestral sequence reconstruction pinpoints adaptations that enable avian influenza virus transmission in pigs. Nature Microbiology 6: 1455–1465

Nature Microbiology 6: 1455–1465 – Su W, Harfoot R, Su YCF, DeBeauchamp J, Joseph U, Jayakumar J, Crumpton JC, Jeevan T, Rubrum A, Franks J, Pascua PNQ, Kackos C, Zhang Y, Ji Y, Zhang MT, Leung C, Jones JC, Kercher L, Krauss S, Pleschka S, Chan MCW, Webster RG, Wu CY, Peiris JSM, Webby RJ, Smith GJD, Yen HL  (2021)

Divergent evolutionary trajectories of influenza B viruses underlie their contemporaneous epidemic activity.

Proceedings of the National Academy of Sciences of the United States of America – Virk Ramandeep K; Jayakumar Jayanthi; Mendenhall Ian H; Moorthy Mahesh; Lam Pauline; Linster Martin; Lim Julia; Lin Cui; Oon Lynette L E; Lee Hong Kai; Koay Evelyn S C; Vijaykrishna Dhanasekaran; Smith Gavin J D; Su Yvonne C F (2020)

117 (1); 619-628

Effects of a major deletion in the SARS-CoV-2 genome on the severity of infection and the inflammatory response: an observational cohort study.

Lancet (London, England) – Young Barnaby E; Fong Siew-Wai; Chan Yi-Hao; Mak Tze-Minn; Ang Li Wei; Anderson Danielle E; Lee Cheryl Yi-Pin; Amrun Siti Naqiah; Lee Bernett; Goh Yun Shan; Su Yvonne C F; Wei Wycliffe E; Kalimuddin Shirin; Chai Louis Yi Ann; Pada Surinder; Tan Seow Yen; Sun Louisa; Parthasarathy Purnima; Chen Yuan Yi Constance; Barkham Timothy; Lin Raymond Tzer Pin; Maurer-Stroh Sebastian; Leo Yee-Sin; Wang Lin-Fa; Renia Laurent; Lee Vernon J; Smith Gavin J D; Lye David Chien; Ng Lisa F P (2020)

396 (10251); 603-611

Discovery and Genomic Characterization of a 382-Nucleotide Deletion in ORF7b and ORF8 during the Early Evolution of SARS-CoV-2.

mBio – Su Yvonne C F; Anderson Danielle E; Young Barnaby E; Linster Martin; Zhu Feng; Jayakumar Jayanthi; Zhuang Yan; Kalimuddin Shirin; Low Jenny G H; Tan Chee Wah; Chia Wan Ni; Mak Tze Minn; Octavia Sophie; Chavatte Jean-Marc; Lee Raphael T C; Pada Surinder; Tan Seow Yen; Sun Louisa; Yan Gabriel Z; Maurer-Stroh Sebastian; Mendenhall Ian H; Leo Yee-Sin; Lye David Chien; Wang Lin-Fa; Smith Gavin J D (2020)

11 (4);

Avian Influenza A(H9N2) Virus in Poultry Worker, Pakistan, 2015.

Emerging infectious diseases – Ali Muzaffar; Yaqub Tahir; Mukhtar Nadia; Imran Muhammad; Ghafoor Aamir; Shahid Muhammad Furqan; Naeem Muhammad; Iqbal Munir; Smith Gavin J D; Su Yvonne C F (2019)

25 (1); 136-139