Redox-dependent AMPK inactivation disrupts metabolic adaptation to glucose starvation in xCT-overexpressing cancer cells.Lee Y, Itahana Y, Ong CC,
Itahana K (2022)
J Cell Sci. 135:15:jcs259090
Mutant TP53 interacts with BCAR1 to contribute to cancer cell invasion.
Guo AK, Itahana Y, Seshachalam VP, Chow HY, Ghosh S, Itahana K (2021)
Br J Cancer. 124:1:299-312
Potassium channel dysfunction in human neuronal models of Angelman syndrome.
Sun AX, Yuan Q, Fukuda M, Yu W, Yan H, Lim GGY, Nai MH, D'Agostino GA, Tran HD, Itahana Y, Wang D, Lokman H, Itahana K, Lim SWL, Tang J, Chang YY, Zhang M, Cook SA, Rackham OJL, Lim CT, Tan EK, Ng HH, Lim KL, Jiang YH, Je HS (2019)
Science 366:6472:1486-1492
ABCB1 protects bat cells from DNA damage induced by genotoxic compounds.Koh J, Itahana Y, Mendenhall IH, Low D, Soh EXY, Guo AK, Chionh YT, Wang LF*,
Itahana K* (2019)
Nat Commun. 10:1:2820 (*co-corresponding authors)
High basal heat-shock protein expression in bats confers resistance to cellular heat/oxidative stress.Chionh YT, Cui J, Koh J, Mendenhall IH, Ng JHJ, Low D,
Itahana K, Irving AT, Wang LF (2019)
Cell Stress Chaperones 24:4:835-849
Tumor suppressor p14ARF enhances IFNγ-activated immune response by inhibiting PIAS1 via SUMOylation.Alagu J, Itahana Y, Sim F, Chao SH, Bi X,
Itahana K (2018)
J Immunol. pii: ji1800327
Ca2+-dependent PP2Ac demethylation promotes cancer cell death in response to glucose deprivation independently of inhibiting glycolysis.Lee HY, Itahana Y, Schuechner S, Fukuda M, Je HS, Ogris E, Virshup DM,
Itahana K (2018)
Sci Signal. 11:512, pii: eaam7893
Emerging Roles of p53 Family Members in Glucose Metabolism.Itahana Y,
Itahana K (2018)
Int J Mol Sci. 19:3, pii: E776 (review)
p32 regulates ER stress and lipid homeostasis by down-regulating GCS1 expression.Liu Y, Leslie PL, Jin A,
Itahana K, Graves LM, Zhang Y (2018)
FASEB J. fj201701004RR
p32 heterozygosity protects against age- and diet-induced obesity by increasing energy expenditure.Liu Y, Leslie PL, Jin A,
Itahana K, Graves LM, Zhang Y (2017)
Sci Rep.18:7:1:5754.
Histone modifications and p53 binding poise the p21 promoter for activation in human embryonic stem cells.Itahana Y*, Zhang J*, Göke J, Vardy LA, Han R, Iwamoto K, Engin C, Robson P, Pouladi MA, Colman A**,
Itahana K** (2016)
Sci Rep. 6:28112 (*equal contribution) (**co-corresponding authors)
Germline hemizygous deletion of CDKN2A-CDKN2B locus in a patient presenting with Li-Fraumeni syndrome.Chan SH, Lim WK, Michalski S, Lim JQ, Ishak ND, Met-Domestici M, Ng CCY, Vikstrom K, Esplin ED, Fulbright J, Ang MK, Wee J, Sittampalam K, Farid M, Lincoln SE,
Itahana K, Abdullah S, Teh BT, Ngeow J (2016)
npj Genomic Medicine 1:16015
Transglutaminase 2 (TGM2) contributes to a p53-induced autophagy program to prevent oncogenic transformation. Yeo SY*, Itahana Y*, Guo AK, Han R, Iwamoto K, Nguyen TH, Bao Y, Kleiber K, Wu YJ, Bay BH, Voorhoeve PM**,
Itahana K** (2016)
eLife 5:e07101 (*equal contribution) (**co-corresponding authors)
TRIM28 is an E3 ligase for ARF-mediated NPM1/B23 SUMOylation that represses centrosome amplification. Neo SH*, Itahana Y*, Alagu J, Kitagawa M, Guo A, Lee SH, Tang K,
Itahana K (2015)
Mol Cell Biol. 35:16:2851-2863 (*equal contribution)
Quiescence does not affect p53 and stress response by irradiation in human lung fibroblasts.Dai J,
Itahana K*, Baskar R* (2015)
Biochem Biophys Res Commun 458:1:104-109 (*co-corresponding authors)
The uric acid transporter SLC2A9 is a direct target gene of the tumor suppressor p53 contributing to antioxidant defense.Itahana Y, Han R, Barbier S, Lei Z, Rozen S,
Itahana K (2015)
Oncogene 34:14:1799-1810
Colorimetric detection of senescence-associated β galactosidase.Itahana K, Itahana Y, Dimri GP. (2013)
Methods Mol Biol. 965:143-156
TP53 genomic status regulates sensitivity of gastric cancer cells to the histone methylation inhibitor 3-Deazaneplanocin A (DZNep)Cheng LL, Itahana Y, Lei ZD, Chia NY, Wu Y, Yu Y, Zhang SL, Thike AA, Pandey A, Rozen S, Voorhoeve PM, Yu Q, Tan PH, Bay BH,
Itahana K*, Tan P* (2012).
Clin Cancer Res. 18:15:4201-4212 (*co-corresponding authors)
Emerging roles of mitochondrial p53 and ARF.Itahana Y,
Itahana K (2012)
Curr Drug Targets. 13:13:1633-1640 (Review)
The diverse and complex roles of radiation on cancer treatment: therapeutic target and genome maintenance.Baskar R, Yap SP, Chua KL,
Itahana K (2012)
Am J Cancer Res. 2:4:372-382 (Review)
Mdm2 RING mutation enhances p53 transcriptional activity and p53-p300 interaction.Clegg HV, Itahana Y,
Itahana K, Ramalingam S, Zhang Y (2012)
PLoS One. 7:5:e38212
Depletion of guanine nucleotides leads to the Mdm2-dependent proteasomal degradation of nucleostemin.Huang M,
Itahana K, Zhang Y, Mitchell BS (2009)
Cancer Res. 69:7:3004-3012
Mitochondrial p32 is a critical mediator of ARF-induced apoptosis.Itahana K and Zhang Y (2008)
Cancer Cell 13:6:542-553 (featured article)
Targeted inactivation of Mdm2 RING finger E3 ubiquitin ligase activity in the mouse reveals mechanistic insights into p53 regulation.Itahana K, Mao H, Jin A, Itahana Y, Clegg H, Lindström MS, Bhat K, Godfrey VL, Evan GI, Zhang Y (2007)
Cancer Cell 12:4:355-366 (cover article, comment in Nature Reviews Cancer 2007, 7(12), 896)
Tumor suppressor ARF degrades B23, a nucleolar protein involved in ribosome biogenesis and cell proliferation.Itahana K, Bhat KP, Jin A, Itahana Y, Hawke D, Kobayashi R, Zhang Y (2003)
Mol Cell. 12:5:1151-1164
Control of the replicative life span of human fibroblasts by p16 and the polycomb protein Bmi-1.Itahana K, Zou Y, Itahana Y, Martinez JL, Beausejour C, Jacobs JJ, Van Lohuizen M, Band V, Campisi J, Dimri GP (2003)
Mol Cell Biol. 23:1:389-401
A role for p53 in maintaining and establishing the quiescence growth arrest in human cells.Itahana K, Dimri GP, Hara E, Itahana Y, Zou Y, Desprez PY, Campisi J. (2002)
J Biol Chem. 277:20:18206-18214