Directory

Macrophages are innate immune cells that regulate organ development, function, and disease. The latter includes a wide range of disorders including cancer, infectious, autoimmune, and inflammatory diseases, where macrophage plasticity drives or supports the transition between homeostasis and disease. I have spent the last 9 years studying the role of macrophages mainly in metabolic diseases (obesity, type 2 diabetes, and ageing), but also in chronic kidney diseases (CKDs). Moreover, I have studied the metabolic pathways that support macrophage function (migration, inflammation, phagocytosis, and resolution) during sterile inflammation and infection (E. coli, S. Thyphimurium, viral dsDNA). Hence, my main research interest pivots on understanding “where, when and how” macrophages and macrophage function is involved in disease and find ways to target it. 

Cardiac glycosides are broad-spectrum senolytics.

Nature metabolism – Guerrero Ana; Herranz Nicolás; Sun Bin; Wagner Verena; Gallage Suchira; Guiho Romain; Wolter Katharina; Pombo Joaquim; Irvine Elaine E; Innes Andrew J; Birch Jodie; Glegola Justyna; Manshaei Saba; Heide Danijela; Dharmalingam Gopuraja; Harbig Jule; Olona Antoni; Behmoaras Jacques; Dauch Daniel; Uren Anthony G; Zender Lars; Vernia Santiago; Martínez-Barbera Juan Pedro; Heikenwalder Mathias; Withers Dominic J; Gil Jesús (2019)

1 (11); 1074-1088

The NLRP3 inflammasome: regulation by metabolic signals.

Trends in immunology – Olona Antoni; Leishman Stuart; Anand Paras K (2022)

43 (12); 978-989

Multi-tissue profiling of oxylipins reveal a conserved up-regulation of epoxide:diol ratio that associates with white adipose tissue inflammation and liver steatosis in obesity.

EBioMedicine – Hateley Charlotte; Olona Antoni; Halliday Laura; Edin Matthew L; Ko Jeong-Hun; Forlano Roberta; Terra Ximena; Lih Fred B; Beltrán-Debón Raúl; Manousou Penelopi; Purkayastha Sanjay; Moorthy Krishna; Thursz Mark R; Zhang Guodong; Goldin Robert D; Zeldin Darryl C; Petretto Enrico; Behmoaras Jacques (2024)

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Cardiac glycosides cause cytotoxicity in human macrophages and ameliorate white adipose tissue homeostasis.

British journal of pharmacology – Olona Antoni; Hateley Charlotte; Guerrero Ana; Ko Jeong-Hun; Johnson Michael R; Anand Paras K; Thomas David; Gil Jesus; Behmoaras Jacques (2022)

179 (9); 1874-1886

Sphingolipid metabolism during Toll-like receptor 4 (TLR4)-mediated macrophage activation.

British journal of pharmacology – Olona Antoni; Hateley Charlotte; Muralidharan Sneha; Wenk Markus R; Torta Federico; Behmoaras Jacques (2021)

178 (23); 4575-4587

Acute Iron Deprivation Reprograms Human Macrophage Metabolism and Reduces Inflammation In Vivo.

Cell reports – Pereira Marie; Chen Tai-Di; Buang Norzawani; Olona Antoni; Ko Jeong-Hun; Prendecki Maria; Costa Ana S H; Nikitopoulou Efterpi; Tronci Laura; Pusey Charles D; Cook H Terence; McAdoo Stephen P; Frezza Christian; Behmoaras Jacques (2019)

28 (2); 498-511.e5

Epoxygenase inactivation exacerbates diet and aging-associated metabolic dysfunction resulting from impaired adipogenesis.

Molecular metabolism – Olona Antoni; Terra Ximena; Ko Jeong-Hun; Grau-Bové Carme; Pinent Montserrat; Ardevol Anna; Diaz Ana Garcia; Moreno-Moral Aida; Edin Matthew; Bishop-Bailey David; Zeldin Darryl C; Aitman Timothy J; Petretto Enrico; Blay Mayte; Behmoaras Jacques (2018)

11 18-32

Immunolipidomics Reveals a Globoside Network During the Resolution of Pro-Inflammatory Response in Human Macrophages.

Frontiers in immunology – Muralidharan Sneha; Torta Federico; Lin Michelle K; Olona Antoni; Bagnati Marta; Moreno-Moral Aida; Ko Jeong-Hun; Ji Shanshan; Burla Bo; Wenk Markus R; Rodrigues Hosana G; Petretto Enrico; Behmoaras Jacques (2022)

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Adipoclast: a multinucleated fat-eating macrophage.

BMC biology – Olona Antoni; Mukhopadhyay Subhankar; Hateley Charlotte; Martinez Fernando O; Gordon Siamon; Behmoaras Jacques (2021)

19 (1);

BCAT1 affects mitochondrial metabolism independently of leucine transamination in activated human macrophages.

Journal of cell science – Ko Jeong-Hun; Olona Antoni; Papathanassiu Adonia E; Buang Norzawani; Park Kwon-Sik; Costa Ana S H; Mauro Claudio; Frezza Christian; Behmoaras Jacques (2020)

133 (22);

NLRP3 Inflammasome Priming and Activation Are Regulated by a Phosphatidylinositol-Dependent Mechanism.

ImmunoHorizons – Hamilton Claire; Olona Antoni; Leishman Stuart; MacDonald-Ramsahai Kelly; Cockcroft Shamshad; Larrouy-Maumus Gerald; Anand Paras K (2022)

6 (8); 642-659

Nearly monodispersed, emission-tuneable conjugated polymer nanoparticles

Sensors and diagnostics – Struan Bourke, Laura Urbano, Megan M. Midson, Antoni Olona, Basma Qazi-Choudhry, Maryna Panamarova, Ferran Valderrama, Nicholas J. Long, Lea-Ann Dailey and Mark Green.  (2022)

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