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Tan Siew Wei Gavin

Associate Professor

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Education Qualifications: MBBS, M Med(Ophth), MRCSEd, FRCS(Ed), FAMS, PhD(NUS)

Dr Gavin Tan is a Senior Consultant in the Surgical Retinal Department of the Singapore National Eye Centre and Changi General Hospital. He is also visiting Senior Consultant for the Ophthalmology service at the KK Women and Children’s Hospital providing the pediatric retina service. In addition, he is a clinician scientist at the Singapore Eye Research Institute (SERI). Dr Gavin Tan is a trained surgical and medical vitreoretinal specialist with a clinical interest in diabetic retinopathy, age-related macular degeneration, intraocular tumours, retinal detachments and pediatric vitreoretinal diseases. He set up the first ocular plaque brachytherapy service in Singapore in conjunction with the National Cancer Centre Singapore. He is also a highly experienced cataract surgeon with expertise in complicated and dislocated cataracts; and intraocular lens fixation. As part of SNEC efforts to adapt to the rapidly evolving technological landscape in ophthalmology and medicine, Dr Tan setup the Digital Transformation office as director with the goal, of leveraging technology to transformation patient care. 

Dr Tan is the clinical director of the SNEC Ocular Reading Centre (SORC), which is one of the major imaging reading centres for diabetic retinopathy and retina clinical trials in Singapore. He is involved in the development and implementation of a national diabetic retinopathy telemedicine screening program in Singapore and is studying the use of novel approaches including optical coherence tomography, automated detection of retinopathy and personalized screening intervals to improve cost effectiveness and efficacy of diabetic retinopathy screening. SORC is also instrumental in the development artificial intelligence methods for the interpretation of retinal imaging. 

Besides imaging, Dr Tan has research studies aimed at identifying novel biomarkers and improving treatment strategies in diabetic retinopathy. His goal is to eliminate diabetic visual impairment and blindness by developing new methods in screening, diagnosis and treatment of diabetic retinopathy with the goal of transforming clinical care and improving patient outcomes. His interest in diabetic retinopathy has also led to multiple collaborations with the Endocrine and Nephrology in diabetic complication. He served as the service chief for ophthalmology and subsequently the lead for diabetic complications at the SingHealth Duke-NUS Diabetes Centre. Dr Tan is also interested in cell replacement therapy and is currently working with collaborators on the development of pluripotent stem cell derived cell replacement therapy for macular diseases at SERI. Dr Tan has published more than 70 papers in peer-reviewed journals and has presented over 30 papers in local and overseas meetings. He has also been awarded various competitive grants for his work.

Dr Gavin Tan graduated with a Bachelor in Medicine and Surgery (MBBS) with Distinction in Biochemistry and Medicine from the National University of Singapore in 2003. He was awarded multiple Dean’s List Awards and the Singapore Medical Association (SMA) Medal for academic excellence. After his ophthalmology residency training at SNEC, where he served as Chief Resident, he went on to complete a two-year Fellowship in Vitreo-Retinal Diseases and Surgery at SNEC in 2014. During this time, he obtained his post-graduate qualifications in Ophthalmology, including a Fellowship of the Royal College of Surgeons in Edinburgh (FRCSEd) and Fellowship of the Academy of Medicine Singapore (FAMS) in 2012. Under the SingHealth scholarship, Dr Gavin Tan pursued further overseas training in the field of Vitero-Retinal diseases. At the Byer Eye Institute at Stanford University, USA, he mentored with world-renowned Retinal specialists in Pediatric Vitero-Retinal diseases and the use of novel lasers for Retinal diseases. At the Jules Stein Eye Institute at the University of California Los Angeles (UCLA), he honed his expertise in advanced retinal imaging, management of intraocular tumours, and the use of human stem cell derived RPE in the treatment of Retinal diseases.

 

Professional Appointments and Committee Memberships:

  • Treasurer, Singapore Society of Ophthalmologist (2018 – present)
  • Member, Macula Society (2018- present)
  • Council Member, Asia-Pacific Teleophthalmology Society (2016 - present)
  • Member, American Society of Retina Surgeons (ASRS) (2014 - present)
  • Fellow, Royal College of Surgeons Edinburgh (2012 - present)
  • Member, Association for Research in Vision and Ophthalmology (ARVO) (2004 - present)
  • Member, Singapore Medical Association (2003 - present)

Awards:

  • APAO Achievement Award (2019)
  • MOH National Clinical Excellence Team Award (2019)
  • Clinical Research Excellence Award, SingHealth (2017)
  • SingHealth-MOH HMDP Award: Fellowship in vitreo-retinal diseases and novel laser retinal treatments (Stanford University) & Fellowship in vitreo-retinal diseases: stem cell treatments for retinal diseases (UCLA, Jules Stein Eye Institute) (2014)
  • Travel Grant, The Association for Research in Vision and Ophthalmology (ARVO) (2013)

Research Interests: 

  • Diabetic Retinopathy
  • Cell Replacement therapy in Retinal Diseases
  • Retina imaging
  • Telemedicine and Artificial Intelligence in Ophthalmology

Selected Publications:

1. Tan GS, Gan A, Sabanayagam C, Tham YC, Neelam K, Mitchell P, Wang JJ, Lamoureux EL, Cheng CY, Wong TY. Ethnic Differences in the Prevalence and Risk Factors of Diabetic Retinopathy: The Singapore Epidemiology of Eye Diseases Study. Ophthalmology. 2017 Dec 4. [Epub ahead of print]
              
2. Ting DSW, Cheung CY, Lim G, Tan GSW, Quang ND, Gan A, Hamzah H, Garcia-Franco R, San Yeo IY, Lee SY, Wong EYM, Sabanayagam C, Baskaran M, Ibrahim F, Tan NC, Finkelstein EA, Lamoureux EL, Wong IY, Bressler NM, Sivaprasad S, Varma R, Jonas JB, He MG, Cheng CY, Cheung GCM, Aung T, Hsu W, Lee ML, Wong TY. Development and Validation of a Deep Learning System for Diabetic Retinopathy and Related Eye Diseases Using Retinal Images From Multiethnic Populations With Diabetes. JAMA. 2017 Dec 12;318(22):2211-2223 
              
3. Sobrin L, Chong YH, Fan Q, Gan A, … Tan G, …, Wong TY, Cheng CY. Genetically Determined Plasma Lipid Levels and Risk of Diabetic Retinopathy: A Mendelian Randomization Study. Diabetes. 2017 Sep 26. [Epub ahead of print]
              
4. Liew G, Lei Z, Tan G, Joachim N, Ho IV, Wong TY, Mitchell P, Gopinath B, Crossett B. Metabolomics of Diabetic Retinopathy. Curr Diab Rep. 2017 Sep 23;17(11):102
              
5. Fenner BJ, Tan GS, Tan AC, Yeo IY, Wong TY, Cheung GC. Identification of imaging features that determine quality and repeatability of retinal capillary plexus density measurements in OCT angiography. Br J Ophthalmol. 2017 Aug 16. [Epub ahead of print]
              
6. Cheung CY, Sabanayagam C, Law AK, Kumari N, Ting DS, Tan G, Mitchell P, Cheng CY, Wong TY. Retinal vascular geometry and 6 year incidence and progression of diabetic retinopathy. Diabetologia. 2017 june. [Epub ahead of print]
              
7. Ting DSW, Tan GSW. Telemedicine for Diabetic Retinopathy Screening. JAMA Ophthalmol. 2017 May 18. [Epub ahead of print]
              
8. Ting DS, Tan GS, Agrawal R, Yanagi Y, Sie NM, Wong CW, San Yeo IY, Lee SY, Cheung CM, Wong TY. Optical Coherence Tomographic Angiography in Type 2 Diabetes and Diabetic Retinopathy. JAMA Ophthalmol. 2017 Apr 1;135(4):306-312
              
9. Chong YH, Fan Q, Tham YC, Gan A, Tan SP, Tan G, Wang JJ, Mitchell P, Wong TY, Cheng CY.Type 2 Diabetes Genetic Variants and Risk of Diabetic Retinopathy. Ophthalmology. 2017 Mar;124(3):336-342 
              
10. Ting DS, Tan KA, Phua V, Tan GS, Wong CW, Wong TY. Biomarkers of Diabetic Retinopathy. Curr Diab Rep. 2016 Dec;16(12):125
              
11. Nguyen HV, Tan GS, Tapp RJ, Mital S, Ting DS, Wong HT, Tan CS, Laude A, Tai ES, Tan NC, Finkelstein EA, Wong TY, Lamoureux EL. Cost-effectiveness of a National Telemedicine Diabetic Retinopathy Screening Program in Singapore. Ophthalmology. 2016 Dec;123(12):2571-2580
              
12. Toy BC, Schachar IH, Tan GS, Moshfeghi DM. Chronic Vascular Arrest as a Predictor of Bevacizumab Treatment Failure in Retinopathy of Prematurity. Ophthalmology. 2016 Oct;123(10):2166-75
              
13. Gavin S Tan, Ning Cheung, Rafael Simo, Gemmy C Cheung, Tien Yin Wong, MD, PhD. Diabetic Macular Edema. Lancet Diabetes Endocrinol. 2016 Aug 2
              
14. Schwartz SD, Tan G, Hosseini H, Nagiel A. Subretinal Transplantation of Embryonic Stem Cell-Derived Retinal Pigment Epithelium for the Treatment of Macular Degeneration: An Assessment at 4 Years. Invest Ophthalmol Vis Sci. 2016 Apr 1;57(5):ORSFc1-9
              
15. Ng DS, Chiang PP, Tan G, Cheung CM, Cheng CY, Cheung CY, Wong TY, Lamoureux EL, Ikram MK. Retinal Ganglion Cell Neuronal Damage in Diabetes and Diabetic Retinopathy. Clin Experiment Ophthalmol. 2016 Feb 12. [Epub]
              
16. Goh JK, Cheung CY, Sim SS, Tan PC, Tan GS, Wong TY. Retinal Imaging Techniques for Diabetic Retinopathy Screening. J Diabetes Sci Technol. 2016 Feb 1;10(2):282-94
              
17. Chen L, Cheng CY, Choi H, Ikram MK, Sabanayagam C, Tan GS, et al. Plasma Metabonomic Profiling of Diabetic Retinopathy. Diabetes. 2016 Jan 28. pii: db150661. [Epub ahead of print]
              
18. Tan GS, Kuehlewein L, Sadda SR, Sarraf D, Schwartz SD. Subretinal neovascularization in macular telangiectasia type 2: Optical coherence tomographic angiography and treatment response. Retinal Cases & Brief Reports. 2015. 9(4):286-9
              
19. Ng WY, Tan GS, Ong PG, Cheng CY, Cheung CY, Wong DW, Mathur R, Chow KY, Wong TY, Cheung GC. Incidence of myocardial infarction, stroke and death in patients with age-related macular degeneration treated with intra-vitreal anti vascular endothelial growth factor therapy. Am J Ophthalmol. 2014 Dec 9
              
20. Tan, G.S, Ikram, M.K, Wong, T.Y. Traditional and novel risk factors of diabetic retinopathy and research challenges. Current Medicinal Chemistry. 2013 Sept; 20(26): 3189-3199