Directory

Directory

Vaidehi Krishnan

Principal Research Scientist, Signature Research Programme in Cancer & Stem Cell Biology

vaidehi.krishnan@duke-nus.edu.sg

About

Publications

Bio

Vaidehi Krishnan is a Principal Research Scientist at the Cancer & Stem Cell Biology Programme of Duke NUS Medical school since 2018. She obtained her PhD in Biochemistry from the Cancer Research Institute (Tata Memorial Hospital), India. Subsequently, her research has focused on understanding how genomic integrity is disrupted in aging and cancer. Over the last few years, her work has involved the use of single-cell approaches to uncover novel features of drug resistance in Chronic Myeloid Leukemia (CML). Her current interest spans basic and translational oncology research with a focus on the development of new biomarkers to predict therapeutic response heterogeneity and NK cell-based immunotherapy approaches for haematological malignancies.

Education

Doctor of Philosophy

University of Mumbai, India

Master of Science Hons Class 1

The Maharaja Sayajirao University of Baroda, United States

Bachelor of Science

University of Bombay, India

Publications

A single-cell atlas identifies pretreatment features of primary imatinib resistance in chronic myeloid leukemia.

Blood – Krishnan Vaidehi; Schmidt Florian; Nawaz Zahid; Venkatesh Prasanna Nori; Lee Kian Leong; Ren Xi; Chan Zhu En; Yu Mengge; Makheja Meera; Rayan Nirmala Arul; Lim Michelle Gek Liang; Cheung Alice Man Sze; Bari Sudipto; Chng Wee Joo; Than Hein; Ouyang John; Rackham Owen; Tan Tuan Zea; Hwang William Ying Khee; Chuah Charles; Prabhakar Shyam; Ong S Tiong (2023)

141 (22); 2738-2755

DOI

DNA replication checkpoint prevents precocious chromosome segregation by regulating spindle behavior.

Molecular cell – Krishnan Vaidehi; Nirantar Saurabh; Crasta Karen; Cheng Alison Yi Hui; Surana Uttam (2004)

16 (5); 687-700

DOI

Histone H4 lysine 16 hypoacetylation is associated with defective DNA repair and premature senescence in Zmpste24-deficient mice.

Proceedings of the National Academy of Sciences of the United States of America – Krishnan Vaidehi*; Chow Maggie Zi Ying*; Wang Zimei*; Zhang Le; Liu Baohua; Liu Xinguang; Zhou Zhongjun*co-first authors (2011)

108 (30); 12325-30

DOI

Altered melanoma cell surface glycosylation mediates organ specific adhesion and metastasis via lectin receptors on the lung vascular endothelium.

Clinical & experimental metastasis – Krishnan Vaidehi; Bane Sanjay M; Kawle Poonam D; Naresh Kikkeri N; Kalraiya Rajiv D (2005)

22 (1); 11-24

DOI

TGFβ Promotes Genomic Instability after Loss of RUNX3.

Cancer research – Krishnan Vaidehi*; Chong Yu Lin; Tan Tuan Zea; Kulkarni Madhura; Bin Rahmat Muhammad Bakhait; Tay Lavina Sierra; Sankar Haresh; Jokhun Doorgesh S; Ganesan Amudha; Chuang Linda Shyue Huey; Voon Dominic C; Shivashankar G V; Thiery Jean-Paul*; Ito Yoshiaki**-co-corresponding authors (2018)

78 (1); 88-102

DOI

A novel cell cycle inhibitor stalls replication forks and activates S phase checkpoint.

Cell cycle (Georgetown, Tex.) – Krishnan Vaidehi; Dirick Léon; Lim Hong Hwa; Lim Tiffany Siew Joo; Si-Hoe San Ling; Cheng Chee Seng; Yap Kai Lee; Ting Anthony; Schwob Etienne; Surana Uttam (2007)

6 (13); 1621-30

DOI

Disruption of Runx1 and Runx3 leads to bone marrow failure and leukemia predisposition due to transcriptional and DNA repair defects.

Cell Reports – Wang Chelsia Qiuxia*; Krishnan Vaidehi1* Tay Lavina Sierra*; Chin Desmond Wai Loon; Koh Cai Ping; Chooi Jing Yuan; Nah Giselle Sek Suan; Du Linsen; Jacob Bindya; Yamashita Namiko; Lai Soak Kuan; Tan Tuan Zea; Mori Seiichi; Tanuichi Ichiro; Tergaonkar Vinay; Ito Yoshiaki; Osato Motomi *-co-first author (2014)

8 (3); 767-82

DOI

ATM Expression Predicts Veliparib and Irinotecan Sensitivity in Gastric Cancer by Mediating P53-Independent Regulation of Cell Cycle and Apoptosis.

Molecular cancer therapeutics – Subhash Vinod Vijay; Tan Shi Hui; Yeo Mei Shi; Yan Fui Leng; Peethala Praveen C; Liem Natalia; Krishnan Vaidehi; Yong Wei Peng (2016)

15 (12); 3087-3096

DOI

Aurora kinase-induced phosphorylation excludes transcription factor RUNX from the chromatin to facilitate proper mitotic progression.

Proceedings of the National Academy of Sciences of the United States of America – Chuang Linda Shyue Huey; Khor Jian Ming; Lai Soak Kuan; Garg Shubham; Krishnan Vaidehi; Koh Cheng-Gee; Lee Sang Hyun; Ito Yoshiaki (2016)

113 (23); 6490-5

DOI

RCA2: a scalable supervised clustering algorithm that reduces batch effects in scRNA-seq data.

Nucleic acids research – Schmidt Florian; Ranjan Bobby; Lin Quy Xiao Xuan; Krishnan Vaidehi; Joanito Ignasius; Honardoost Mohammad Amin; Nawaz Zahid; Venkatesh Prasanna Nori; Tan Joanna; Rayan Nirmala Arul; Ong Sin Tiong; Prabhakar Shyam (2021)

49 (15); 8505-8519

DOI

RUNX Poly(ADP-Ribosyl)ation and BLM Interaction Facilitate the Fanconi Anemia Pathway of DNA Repair.

Cell reports – Tay Lavina Sierra; Krishnan Vaidehi; Sankar Haresh; Chong Yu Lin; Chuang Linda Shyue Huey; Tan Tuan Zea; Kolinjivadi Arun Mouli; Kappei Dennis; Ito Yoshiaki (2018)

24 (7); 1747-1755

DOI

Lysine acetyltransferase Tip60 is required for hematopoietic stem cell maintenance.

Blood – Numata Akihiko; Kwok Hui Si; Zhou Qi-Ling; Li Jia; Tirado-Magallanes Roberto; Angarica Vladimir Espinosa; Hannah Rebecca; Park Jihye; Wang Chelsia Qiuxia; Krishnan Vaidehi; Rajagopalan Deepa; Zhang Yanzhou; Zhou Siqin; Welner Robert S; Osato Motomi; Jha Sudhakar; Bohlander Stefan K; Göttgens Berthold; Yang Henry; Benoukraf Touati; Lough John W; Bararia Deepak; Tenen Daniel G (2020)

136 (15); 1735-1747

DOI

The RUNX Family of Proteins, DNA Repair, and Cancer.

Cells – Krishnan Vaidehi (2023)

12 (8);

DOI

Leukaemia exposure alters the transcriptional profile and function of BCR::ABL1 negative macrophages in the bone marrow niche.

Nature communications – Dawson Amy; Zarou Martha M; Prasad Bodhayan; Bittencourt-Silvestre Joana; Zerbst Désirée; Himonas Ekaterini; Hsieh Ya-Ching; van Loon Isabel; Blanco Giovanny Rodriguez; Ianniciello Angela; Kerekes Zsombor; Krishnan Vaidehi; Agarwal Puneet; Almasoudi Hassan; McCluskey Laura; Hopcroft Lisa E M; Scott Mary T; Baquero Pablo; Dunn Karen; Vetrie David; Copland Mhairi; Bhatia Ravi; Coffelt Seth B; Tiong Ong Sin; Wheadon Helen; Zanivan Sara; Kirschner Kristina; Helgason G Vignir (2024)

15 (1);

DOI

Integrating genetic and epigenetic factors in chronic myeloid leukemia risk assessment: toward gene expression-based biomarkers.

Haematologica – Krishnan Vaidehi; Kim Dennis Dong Hwan; Hughes Timothy P; Branford Susan; Ong S Tiong (2022)

107 (2); 358-370

DOI

DNA damage signalling as an anti-cancer barrier in gastric intestinal metaplasia.

Gut – Krishnan Vaidehi; Lim Debbie Xiu En; Hoang Phuong Mai; Srivastava Supriya; Matsuo Junichi; Huang Kie Kyon; Zhu Feng; Ho Khek Yu; So Jimmy Bok Yan; Khor Christopher; Tsao Stephen; Teh Ming; Fock Kwong Ming; Ang Tiing Leong; Jeyasekharan Anand D; Tan Patrick; Yeoh Khay-Guan; Ito Yoshiaki (2020)

69 (10); 1738-1749

DOI

The CagA Oncoprotein Induces DNA Double Strand Breaks through Fanconi Anemia Pathway Downregulation and Replication Fork Collapse.

International journal of molecular sciences – Kolinjivadi Arun Mouli; Sankar Haresh; Choudhary Ramveer; Tay Lavina Sierra; Tan Tuan Zea; Murata-Kamiya Naoko; Voon Dominic Chih-Cheng; Kappei Dennis; Hatakeyama Masanori; Krishnan Vaidehi; Ito Yoshiaki (2022)

23 (3);

DOI

Directory

Bio

Education

Doctor of Philosophy

Master of Science Hons Class 1

Bachelor of Science

Publications

A single-cell atlas identifies pretreatment features of primary imatinib resistance in chronic myeloid leukemia.

DNA replication checkpoint prevents precocious chromosome segregation by regulating spindle behavior.

Histone H4 lysine 16 hypoacetylation is associated with defective DNA repair and premature senescence in Zmpste24-deficient mice.

Altered melanoma cell surface glycosylation mediates organ specific adhesion and metastasis via lectin receptors on the lung vascular endothelium.

TGFβ Promotes Genomic Instability after Loss of RUNX3.

A novel cell cycle inhibitor stalls replication forks and activates S phase checkpoint.

Disruption of Runx1 and Runx3 leads to bone marrow failure and leukemia predisposition due to transcriptional and DNA repair defects.

ATM Expression Predicts Veliparib and Irinotecan Sensitivity in Gastric Cancer by Mediating P53-Independent Regulation of Cell Cycle and Apoptosis.

Aurora kinase-induced phosphorylation excludes transcription factor RUNX from the chromatin to facilitate proper mitotic progression.

RCA2: a scalable supervised clustering algorithm that reduces batch effects in scRNA-seq data.

RUNX Poly(ADP-Ribosyl)ation and BLM Interaction Facilitate the Fanconi Anemia Pathway of DNA Repair.

Lysine acetyltransferase Tip60 is required for hematopoietic stem cell maintenance.

The RUNX Family of Proteins, DNA Repair, and Cancer.

Leukaemia exposure alters the transcriptional profile and function of BCR::ABL1 negative macrophages in the bone marrow niche.

Integrating genetic and epigenetic factors in chronic myeloid leukemia risk assessment: toward gene expression-based biomarkers.

DNA damage signalling as an anti-cancer barrier in gastric intestinal metaplasia.

The CagA Oncoprotein Induces DNA Double Strand Breaks through Fanconi Anemia Pathway Downregulation and Replication Fork Collapse.

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