Duke-NUS Medical School

Directory

Wang Yibin

Professor, Signature Research Programme in Cardiovascular & Metabolic Disorders

Programme Director, Signature Research Programme in Cardiovascular & Metabolic Disorders

yibinwang@duke-nus.edu.sg

66011353

$Duke-NUS Medical School$

About

Research Interests

Teaching

Publications

Bio

Dr. Wang obtained his training in molecular genetics and cell biology from Baylor College of Medicine, and conducted post-doctoral research in neurobiology and cardiovascular diseases at The Scripps Research Institute and UC, San Diego. Since 1998, Dr. Wang’s laboratory has focused on genetic network and molecular basis of cardiovascular physiology and diseases. Dr. Wang’s lab has a long track record in discovering novel components and novel interactions in stress-signal transduction pathways in mammalian cells through biochemical, proteomic, molecular and genomic approaches. Recently, Wang lab has also employed systems-based approach in gene and pathway discovery for cardiovascular and metabolic disease. Dr. Wang’s lab has established a broad spectrum of research approaches in cardiac biology, from molecular biology, cell physiology to intact heart physiology, genomics and systems biology. Dr. Wang has been supported by NIH, DoD and other extramural grants throughout his research career and published more than 240 scientific articles. Dr. Wang served as the Chair of Cardiovascular Theme at UCLA from 2015 to 2019, a new initiative to build an integrated Cardiovascular Medicine and Research infrastructure at UCLA. D. Wang has four licensed patents and is a scientific founder of a biotech start-up. In addition to being the PI of an 12 people research team, Dr. Wang is also actively engaged in teaching and education, served as the Education Director for UCLA Cardiovascular Research Laboratories and vice Chair of UCLA Molecular, Cellular and Integrated Physiology Ph.D. program.

Directory

Bio

Education

Doctor of Philosophy (Molecular and Cellular Biology)

Bachelor of Science in Biological Science

Research Interests

Teaching

Publications

The in vivo role of p38 MAP kinases in cardiac remodeling and restrictive cardiomyopathy.

Catabolic Defect of Branched-Chain Amino Acids Promotes Heart Failure.

Systems-based approaches to cardiovascular disease.

p38 Mitogen-activated protein kinase regulates chamber-specific perinatal growth in heart.

The long noncoding RNA Chaer defines an epigenetic checkpoint in cardiac hypertrophy.

RBFox1-mediated RNA splicing regulates cardiac hypertrophy and heart failure.

mRNA Metabolism in Cardiac Development and Disease: Life After Transcription.

Glucagon Receptor Antagonism Ameliorates Progression of Heart Failure.

Protein phosphatase 2Cm is a critical regulator of branched-chain amino acid catabolism in mice and cultured cells.

Targeting BCAA Catabolism to Treat Obesity-Associated Insulin Resistance.

c-Jun N-terminal kinase activation mediates downregulation of connexin43 in cardiomyocytes.

A Sarcoplasmic Reticulum Localized Protein Phosphatase Regulates Phospholamban Phosphorylation and Promotes Ischemia Reperfusion Injury in the Heart.

A novel mitochondrial matrix serine/threonine protein phosphatase regulates the mitochondria permeability transition pore and is essential for cellular survival and development.

Genetic Dissection of Cardiac Remodeling in an Isoproterenol-Induced Heart Failure Mouse Model.

Systems Genetics Approach Identifies Gene Pathways and Adamts2 as Drivers of Isoproterenol-Induced Cardiac Hypertrophy and Cardiomyopathy in Mice.

Mitogen-activated protein kinases in heart development and diseases.

Analysis of transcriptome complexity through RNA sequencing in normal and failing murine hearts.

Multiple omics study identifies an interspecies conserved driver for nonalcoholic steatohepatitis.

Type V Collagen in Scar Tissue Regulates the Size of Scar after Heart Injury.

Wnt11 regulates cardiac chamber development and disease during perinatal maturation.

Directory

Bio

Education

Doctor of Philosophy (Molecular and Cellular Biology)

Bachelor of Science in Biological Science

Research Interests

Teaching

Publications

The in vivo role of p38 MAP kinases in cardiac remodeling and restrictive cardiomyopathy.

Catabolic Defect of Branched-Chain Amino Acids Promotes Heart Failure.

Systems-based approaches to cardiovascular disease.

p38 Mitogen-activated protein kinase regulates chamber-specific perinatal growth in heart.

The long noncoding RNA Chaer defines an epigenetic checkpoint in cardiac hypertrophy.

RBFox1-mediated RNA splicing regulates cardiac hypertrophy and heart failure.

mRNA Metabolism in Cardiac Development and Disease: Life After Transcription.

Glucagon Receptor Antagonism Ameliorates Progression of Heart Failure.

Protein phosphatase 2Cm is a critical regulator of branched-chain amino acid catabolism in mice and cultured cells.

Targeting BCAA Catabolism to Treat Obesity-Associated Insulin Resistance.

c-Jun N-terminal kinase activation mediates downregulation of connexin43 in cardiomyocytes.

A Sarcoplasmic Reticulum Localized Protein Phosphatase Regulates Phospholamban Phosphorylation and Promotes Ischemia Reperfusion Injury in the Heart.

A novel mitochondrial matrix serine/threonine protein phosphatase regulates the mitochondria permeability transition pore and is essential for cellular survival and development.

Genetic Dissection of Cardiac Remodeling in an Isoproterenol-Induced Heart Failure Mouse Model.

Systems Genetics Approach Identifies Gene Pathways and Adamts2 as Drivers of Isoproterenol-Induced Cardiac Hypertrophy and Cardiomyopathy in Mice.

Mitogen-activated protein kinases in heart development and diseases.

Analysis of transcriptome complexity through RNA sequencing in normal and failing murine hearts.

Multiple omics study identifies an interspecies conserved driver for nonalcoholic steatohepatitis.

Type V Collagen in Scar Tissue Regulates the Size of Scar after Heart Injury.

Wnt11 regulates cardiac chamber development and disease during perinatal maturation.

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