Oncology

NMRC Transition Award

Ministry of Health,2017

Excessive fatty acid oxidation induces muscle atrophy in cancer cachexia.

Nature medicine – Fukawa Tomoya; Yan-Jiang Benjamin Chua; Min-Wen Jason Chua; Jun-Hao Elwin Tan; Huang Dan; Qian Chao-Nan; Ong Pauline; Li Zhimei; Chen Shuwen; Mak Shi Ya; Lim Wan Jun; Kanayama Hiro-Omi; Mohan Rosmin Elsa; Wang Ruiqi Rachel; Lai Jiunn Herng; Chua Clarinda; Ong Hock Soo; Tan Ker-Kan; Ho Ying Swan; Tan Iain Beehuat; Teh Bin Tean; Shyh-Chang Ng (2016)

22 (6); 666-71

Reference component analysis of single-cell transcriptomes elucidates cellular heterogeneity in human colorectal tumors.

Nature genetics – Li Huipeng; Courtois Elise T; Sengupta Debarka; Tan Yuliana; Chen Kok Hao; Goh Jolene Jie Lin; Kong Say Li; Chua Clarinda; Hon Lim Kiat; Tan Wah Siew; Wong Mark; Choi Paul Jongjoon; Wee Lawrence J K; Hillmer Axel M; Tan Iain Beehuat; Robson Paul; Prabhakar Shyam (2017)

49 (5); 708-718

Increased α-fetoprotein likely induced by complementary health products.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology – Chua Clarinda; Tan Iain B; Choo Su-Pin; Toh Han-Chong (2013)

31 (6); e80-2

Tumor-derived circulating endothelial cell clusters in colorectal cancer

Science translational Medicine – Cima I, Kong SL, Sengupta D, Tan IB, Phyo WM, Lee D, Hu M, Iliescu C, Alexander I, Goh WL, Rahmani M, Suhaimi NA, Vo JH, Tai JA, Tan JH, Chua C, Ten R, Lim WJ, Chew MH, Hauser CA, van Dam RM, Lim WY, Prabhakar S, Lim B, Koh PK, Robsom P, Ying JY, Hillmer AM, Tan MH (2016)

8 (345);

Identification of molecular subtypes of gastric cancer with different responses to PI3-kinase inhibitors and 5-fluorouracil.

Gastroenterology – Lei Zhengdeng; Tan Iain Beehuat; Das Kakoli; Deng Niantao; Zouridis Hermioni; Pattison Sharon; Chua Clarinda; Feng Zhu; Guan Yeoh Khay; Ooi Chia Huey; Ivanova Tatiana; Zhang Shenli; Lee Minghui; Wu Jeanie; Ngo Anna; Manesh Sravanthy; Tan Elisabeth; Teh Bin Tean; So Jimmy Bok Yan; Goh Liang Kee; Boussioutas Alex; Lim Tony Kiat Hon; Flotow Horst; Tan Patrick; Rozen Steven G (2013)

145 (3); 554-65

High-depth sequencing of over 750 genes supports linear progression of primary tumors and metastases in most patients with liver-limited metastatic colorectal cancer

Genome Biology – Tan IB, Malik S, Ramnarayanan K, McPherson JR, Ho DL, Suzuki Y, Ng SB, Su Y, Lim KH, Koh K, Chew MH, Chan CY, Ten R, Goh BKP, Chung AYF, Tan J, Chan CX, Tay ST, Lazhava A, Nagarajan N, Hillmer AM, Tang CL, Chua C, Teh BT, Rozen S, Tan P (2015)

16

A formalin-fixed paraffin-embedded (FFPE)-based prognostic signature to predict metastasis in clinically low risk stage I/II microsatellite stable colorectal cancer.

Cancer letters – Low Yee Syuen; Blöcker Christopher; McPherson John R; Tang See Aik; Cheng Ying Ying; Wong Joyner Y S; Chua Clarinda; Lim Tony K H; Tang Choong Leong; Chew Min Hoe; Tan Patrick; Tan Iain B; Rozen Steven G; Cheah Peh Yean (2017)

403 13-20

Multiregion ultra-deep sequencing reveals early intermixing and variable levels of intratumoral heterogeneity in colorectal cancer.

Molecular oncology – Suzuki Yuka; Ng Sarah Boonhsi; Chua Clarinda; Leow Wei Qiang; Chng Jermain; Liu Shi Yang; Ramnarayanan Kalpana; Gan Anna; Ho Dan Liang; Ten Rachel; Su Yan; Lezhava Alexandar; Lai Jiunn Herng; Koh Dennis; Lim Kiat Hon; Tan Patrick; Rozen Steven G; Tan Iain Beehuat (2017)

11 (2); 124-139

Technical Validation of a Next-Generation Sequencing Assay for Detecting Actionable Mutations in Patients with Gastrointestinal Cancer.

The Journal of molecular diagnostics : JMD – Wang Sophie R; Malik Simeen; Tan Iain B; Chan Yang Sun; Hoi Qiangze; Ow Jack L; He Cassandra Z; Ching Cindy E; Poh Dianne Y S; Seah Hui Maan; Cheung Katie H T; Perumal Dharuman; Devasia Arun G; Pan Lu; Ang Shimin; Lee Seow Eng; Ten Rachel; Chua Clarinda; Tan Daniel S W; Qu James Z Z; Bylstra Yasmin M; Lim Lionel; Lezhava Alexander; Ng Pauline C; Wong Christopher W; Lim Tony; Tan Patrick (2016)

18 (3); 416-424

Individualised multiplexed circulating tumour DNA assays for monitoring of tumour presence in patients after colorectal cancer surgery

Scientific Reports – Ng SB, Chua C, Ng M, Gan A, Poon PS, Teo M, Fu C, Leow WQ, Lim KH, Chung A, Koo SL, Choo SP, Ho D, Rozen S, Tan P, Wong M, Burkholder WF, Tan IB (2017)

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