Oncology

Academic Medicine
About Academic Medicine
Academic Clinical Programmes
Oncology

Yap Yoon Sim (Ye Yongxin)

Associate Professor, SingHealth Duke-NUS Oncology Academic Clinical Programme

gmsyapys@nus.edu.sg

About

Academic Contributions

Professional

Research Interests

Publications

Bio

Dr Yoon-Sim Yap is a Senior Consultant in the Department of Medical Oncology at National Cancer Centre Singapore, Visiting Consultant at KK Women’s and Children’s Hospital, and Associate Professor at Duke-National University Singapore. She obtained her undergraduate and postgraduate medical degrees from the University of Adelaide in Australia, and is a Fellow of the Royal Australasian College of Physicians.

After completing her specialist training in Medical Oncology in Australia, she did a research fellowship with the Breast Unit at Royal Marsden Hospital, London. Dr. Yap has been practising in Singapore since 2006, focusing specifically on breast cancer. Her research interests include predictive biomarkers and development of novel treatment strategies in addition to survival outcomes. She is actively involved in clinical trials, and is the Principal Investigator of several studies for various compounds including HER2-targeted therapies, CDK inhibitors, selective estrogen receptor degraders, and PI3K inhibitors in addition to investigator-initiated studies. In 2019 and again in 2024, Dr. Yap received the National Medical Research Council (NMRC) Clinician Scientist Award (CSA) for her breast cancer research.

Education

Doctor of Philosophy

University of Adelaide, Australia

Fellow, Royal Aust Coll of Physicians

Royal Australasian College of Physicians, United Kingdom

Bachelor of Medicine, Bachelor of Surgery

University of Adelaide, Australia

NUS Appointment(s)

Clinical Teacher, then Clinical Senior Lecturer, then Clinical Assistant Professor now

Yong Loo Lin School of Medicine, Currently Active

Academic Contribution(s)

Clinician Scientist Award

NMRC,2024

Clinician Scientist Award

NMRC,2019

Singapore Healthcare Quality Service Award (Gold Award)

SingHealth,2010

Singapore Healthcare Quality Service Award (Silver Award)

SingHealth,2009

Medical Oncology Group of Australia/Baxter Trainee Educational Achievement Award

MOGA,2005

Best Trainee Oral Presentation award

MOGA,2004

Golden Key National Honour Society for overall scholastic performance

University of Adelaide,1998

Elder Prize for overall academic performance

University of Adelaide,1992

Professional Appointment(s)

Visiting Consultant, KK Breast Centre

KK Women's and Children's Hospital, Currently Active

Associate Consultant, then Consultant and then Senior Consultant

National Cancer Centre Singapore, 04/2006 -

Clinical Assistant Professor, then Assistant Professor, then Associate Professor

SingHealth Duke-NUS Oncology Academic Clinical Oncology Program (ONCO ACP), Currently Active

Membership

Member

Singapore Society of Oncology, Currently Active

Member; Breast Cancer Faculty Committee Member

European Society of Medical Oncology Breast Cancer Faculty Member, Currently Active

Member

Journal of Breast Cancer Editorial Board, Currently Active

International Steering Committee

Japanese Society of Medical Oncology (JSMO), Currently Active

Member

Breast Cancer Research and Treatment Editorial Board, Currently Active

Member

Therapeutic Advances in Medical Oncology Editorial Board, Steering committee member in breast cancer clinical trials, Currently Active

Research Interests

Observational studies in breast cancer

Clinical trials – including early and late phase trials using novel therapeutic regimens

Molecular research in breast cancer, including the role of oncogenes, tumour suppressor genes and prognostic, predictive biomarkers, liquid biopsies

Publications

Overall Survival with Ribociclib plus Letrozole in Advanced Breast Cancer.

The New England journal of medicine – Hortobagyi Gabriel N; Stemmer Salomon M; Burris Howard A; Yap Yoon-Sim; Sonke Gabe S; Hart Lowell; Campone Mario; Petrakova Katarina; Winer Eric P; Janni Wolfgang; Conte Pierfranco; Cameron David A; André Fabrice; Arteaga Carlos L; Zarate Juan P; Chakravartty Arunava; Taran Tetiana; Le Gac Fabienne; Serra Paolo; O'Shaughnessy Joyce (2022)

386 (10); 942-950

Outcomes in Nonmetastatic Hormone Receptor–Positive HER2-Negative Pure Mucinous Breast Cancer: A Multicenter Cohort Study

Journal of the National Comprehensive Cancer Network – Ryan Ying Cong Tan, Whee Sze Ong, Kyung-Hun Lee, Seri Park, Jabed Iqbal, Yeon Hee Park, Jeong Eon Lee, Jong Han Yu, Ching-Hung Lin, Yen-Shen Lu, Makiko Ono, Takayuki Ueno, Yoichi Naito, Tatsuya Onishi, Geok-Hoon Lim, Su-Ming Tan, Han-Byoel Lee, Jiwon Koh, Wonshik Han, Seock-Ah Im, Veronique Kiak Mien Tan, Nitar Phyu, Fuh-Yong Wong, Puay Hoon Tan, Yoon-Sim Yap (2024)

22 (2D);

Final Results of RIGHT Choice: Ribociclib Plus Endocrine Therapy Versus Combination Chemotherapy in Premenopausal Women With Clinically Aggressive Hormone Receptor–Positive/Human Epidermal Growth Factor Receptor 2–Negative Advanced Breast Cancer

Journal of Clinical Oncology – Lu YS, Mohd Mahidin EIB, Azim H, Eralp Y, Yap YS, Im SA, Rihani J, Gokmen E, Bastawisy A, Karadurmus N, Lim YN, Lim CS, Duc LT, Chung WP, Babu KG, Penkov K, Bowles J, Alfaro TD, Wu J, Gao M, Slimane K, Saghir N (2024)

HER2 expression, copy number variation and survival outcomes in HER2-low non-metastatic breast cancer: an international multicentre cohort study and TCGA-METABRIC analysis.

BMC medicine – Tan Ryan Shea Ying Cong; Ong Whee Sze; Lee Kyung-Hun; Lim Abner Herbert; Park Seri; Park Yeon Hee; Lin Ching-Hung; Lu Yen-Shen; Ono Makiko; Ueno Takayuki; Naito Yoichi; Onishi Tatsuya; Lim Geok-Hoon; Tan Su-Ming; Lee Han-Byoel; Ryu Han Suk; Han Wonshik; Tan Veronique Kiak Mien; Wong Fuh-Yong; Im Seock-Ah; Tan Puay Hoon; Chan Jason Yongsheng; Yap Yoon-Sim (2022)

20 (1);

Ribociclib as First-Line Therapy for HR-Positive, Advanced Breast Cancer

N Engl J Med – Hortobagyi GN, Stemmer SM, Burris HA, Yap YS, Sonke GS, Paluch-Shimon S, Campone M, Blackwell KL, André F, Winer EP, Janni W, Verma S, Conte P, Arteaga CL, Cameron DA, Petrakova K, Hart LL, Villanueva C, Chan A, Jakobsen E, Nusch A, Burdaeva O, Grischke EM, Alba E, Wist E, Marschner N, Favret AM, Yardley D, Bachelot T, Tseng LM, Blau S, Xuan F, Souami F, Miller M, Germa C, Hirawat S, O'Shaughnessy J (2016)

375 1738-1748

Insights Into Breast Cancer in the East vs the West: A Review

JAMA Oncol – Yap YS, Lu YS, Tamura K, Lee JE, Ko EY, Park YH, Cao AY, Lin CH, Toi M, Wu J, Lee SC (2019)

5 (10); 1489-1496

Predictors of Hand-Foot Syndrome and Pyridoxine for Prevention of Capecitabine-Induced Hand-Foot Syndrome: A Randomized Clinical Trial.

JAMA oncology – Yap Yoon-Sim; Kwok Li-Lian; Syn Nicholas; Chay Wen Yee; Chia John Whay Kuang; Tham Chee Kian; Wong Nan Soon; Lo Soo Kien; Dent Rebecca Alexandra; Tan Sili; Mok Zuan Yu; Koh King Xin; Toh Han Chong; Koo Wen Hsin; Loh Marie; Ng Raymond Chee Hui; Choo Su Pin; Soong Richie Chuan Teck (2017)

3 (11); 1538-1545

Breast cancer in women with neurofibromatosis type 1 (NF1): a comprehensive case series with molecular insights into its aggressive phenotype.

Breast cancer research and treatment – Yap Yoon-Sim; Munusamy Prabhakaran; Lim Cindy; Chan Claire H T; Prawira Aldo; Loke Sau-Yeen; Lim Swee-Ho; Ong Kong-Wee; Yong Wei-Sean; Ng Sarah B H; Tan Iain B H; Callen David F; Lim Jeffrey C T; Thike Aye-Aye; Tan Puay-Hoon; Lee Ann S G (2018)

171 (3); 719-735

Elucidating therapeutic molecular targets in premenopausal Asian women with recurrent breast cancers.

NPJ breast cancer – Yap Yoon-Sim; Singh Angad P; Lim John H C; Ahn Jin-Hee; Jung Kyung-Hae; Kim Jeongeun; Dent Rebecca A; Ng Raymond C H; Kim Sung-Bae; Chiang Derek Y (2018)

Outcomes in breast cancer-does ethnicity matter?

ESMO Open – Yap YS (2023)

8 (3);

Potential value of ctDNA monitoring in metastatic HR + /HER2 - breast cancer: longitudinal ctDNA analysis in the phase Ib MONALEESASIA trial.

BMC medicine – Chiu Joanne; Su Fei; Joshi Mukta; Masuda Norikazu; Ishikawa Takashi; Aruga Tomoyuki; Zarate Juan Pablo; Babbar Naveen; Balbin O Alejandro; Yap Yoon-Sim (2023)

21 (1);

Contrasting Epidemiology and Clinicopathology of Female Breast Cancer in Asians vs the US Population.

Journal of the National Cancer Institute – Lin Ching-Hung; Yap Yoon Sim; Lee Kyung-Hun; Im Seock-Ah; Naito Yoichi; Yeo Winnie; Ueno Takayuki; Kwong Ava; Li Huiping; Huang Shu-Min; Leung Roland; Han Wonshik; Tan Benita; Hu Fu-Chang; Huang Chiun-Sheng; Cheng Ann-Lii; Lu Yen-Shen; (2019)

111 (12); 1298-1306

Adjuvant aromatase inhibitors for early breast cancer after chemotherapy-induced amenorrhoea: caution and suggested guidelines.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology – Smith Ian E; Dowsett Mitch; Yap Yoon-Sim; Walsh Geraldine; Lønning Per E; Santen Richard J; Hayes Daniel (2006)

24 (16); 2444-7

Exploiting metabolic vulnerabilities in breast cancers with NF1 loss.

Cell reports. Medicine – Yap Yoon-Sim; Hu Jiancheng (2023)

4 (4);

Genotype-Phenotype Correlation in NF1: Evidence for a More Severe Phenotype Associated with Missense Mutations Affecting NF1 Codons 844-848.

American journal of human genetics – Koczkowska Magdalena; Chen Yunjia; Callens Tom; Gomes Alicia; Sharp Angela; Johnson Sherrell; Hsiao Meng-Chang; Chen Zhenbin; Balasubramanian Meena; Barnett Christopher P; Becker Troy A; Ben-Shachar Shay; Bertola Debora R; Blakeley Jaishri O; Burkitt-Wright Emma M M; Callaway Alison; Crenshaw Melissa; Cunha Karin S; Cunningham Mitch; D'Agostino Maria D; Dahan Karin; De Luca Alessandro; Destrée Anne; Dhamija Radhika; Eoli Marica; Evans D Gareth R; Galvin-Parton Patricia; George-Abraham Jaya K; Gripp Karen W; Guevara-Campos Jose; Hanchard Neil A; Hernández-Chico Concepcion; Immken LaDonna; Janssens Sandra; Jones Kristi J; Keena Beth A; Kochhar Aaina; Liebelt Jan; Martir-Negron Arelis; Mahoney Maurice J; Maystadt Isabelle; McDougall Carey; McEntagart Meriel; Mendelsohn Nancy; Miller David T; Mortier Geert; Morton Jenny; Pappas John; Plotkin Scott R; Pond Dinel; Rosenbaum Kenneth; Rubin Karol; Russell Laura; Rutledge Lane S; Saletti Veronica; Schonberg Rhonda; Schreiber Allison; Seidel Meredith; Siqveland Elizabeth; Stockton David W; Trevisson Eva; Ullrich Nicole J; Upadhyaya Meena; van Minkelen Rick; Verhelst Helene; Wallace Margaret R; Yap Yoon-Sim; Zackai Elaine; Zonana Jonathan; Zurcher Vickie; Claes Kathleen; Martin Yolanda; Korf Bruce R; Legius Eric; Messiaen Ludwine M (2018)

102 (1); 69-87

Effects of housing value and medical subsidy on treatment and outcomes of breast cancer patients in Singapore: A retrospective cohort study.

The Lancet regional health. Western Pacific – Wong Fuh Yong; Wong Ru Xin; Zhou Siqin; Ong Whee Sze; Pek Pin Pin; Yap Yoon-Sim; Tan Benita Kiat Tee; Ngeow Joanne Yuen Yie; Tan Veronique Kiak Mien; Sim Yirong; Tan Su-Ming; Lim Swee Ho; Madhukumar Preetha; Tan Tira Jing Ying; Loh Kiley Wei-Jen; Ong Marcus Eng Hock; Wong Ting Hway; (2021)

Ribociclib, a CDK 4/6 inhibitor, plus endocrine therapy in Asian women with advanced breast cancer.

Cancer science – Yap Yoon-Sim; Chiu Joanne; Ito Yoshinori; Ishikawa Takashi; Aruga Tomoyuki; Kim Seung Jin; Toyama Tatsuya; Saeki Toshiaki; Saito Mitsue; Gounaris Ioannis; Su Fei; Ji Yan; Han Yu; Gazdoiu Mihaela; Masuda Norikazu (2020)

111 (9); 3313-3326

Emerging systemic therapy options beyond CDK4/6 inhibitors for hormone receptor-positive HER2-negative advanced breast cancer

NPJ Breast Cancer – Ma J, Chan JJ, Toh CH, Yap YS (2023)

9 (1);

Whole-exome sequencing of breast cancer, malignant peripheral nerve sheath tumor and neurofibroma from a patient with neurofibromatosis type 1.

Cancer medicine – McPherson John Richard; Ong Choon-Kiat; Ng Cedric Chuan-Young; Rajasegaran Vikneswari; Heng Hong-Lee; Yu Willie Shun-Shing; Tan Benita Kiat-Tee; Madhukumar Preetha; Teo Melissa Ching-Ching; Ngeow Joanne; Thike Aye-Aye; Rozen Steven George; Tan Puay-Hoon; Lee Ann Siew-Gek; Teh Bin-Tean; Yap Yoon-Sim (2015)

4 (12); 1871-8

Brain metastases in Asian HER2-positive breast cancer patients: anti-HER2 treatments and their impact on survival.

British journal of cancer – Yap Y S; Cornelio G H; Devi B C R; Khorprasert C; Kim S B; Kim T Y; Lee S C; Park Y H; Sohn J H; Sutandyo N; Wong D W Y; Kobayashi M; Landis S H; Yeoh E M; Moon H; Ro J (2012)

107 (7); 1075-82

Oncology

Bio

Education

Doctor of Philosophy

Fellow, Royal Aust Coll of Physicians

Bachelor of Medicine, Bachelor of Surgery

NUS Appointment(s)

Clinical Teacher, then Clinical Senior Lecturer, then Clinical Assistant Professor now

Academic Contribution(s)

Clinician Scientist Award

Clinician Scientist Award

Singapore Healthcare Quality Service Award (Gold Award)

Singapore Healthcare Quality Service Award (Silver Award)

Medical Oncology Group of Australia/Baxter Trainee Educational Achievement Award

Best Trainee Oral Presentation award

Golden Key National Honour Society for overall scholastic performance

Elder Prize for overall academic performance

Professional Appointment(s)

Visiting Consultant, KK Breast Centre

Associate Consultant, then Consultant and then Senior Consultant

Clinical Assistant Professor, then Assistant Professor, then Associate Professor

Membership

Member

Member; Breast Cancer Faculty Committee Member

Member

International Steering Committee

Member

Member

Research Interests

Publications

Overall Survival with Ribociclib plus Letrozole in Advanced Breast Cancer.

Outcomes in Nonmetastatic Hormone Receptor–Positive HER2-Negative Pure Mucinous Breast Cancer: A Multicenter Cohort Study

Final Results of RIGHT Choice: Ribociclib Plus Endocrine Therapy Versus Combination Chemotherapy in Premenopausal Women With Clinically Aggressive Hormone Receptor–Positive/Human Epidermal Growth Factor Receptor 2–Negative Advanced Breast Cancer

HER2 expression, copy number variation and survival outcomes in HER2-low non-metastatic breast cancer: an international multicentre cohort study and TCGA-METABRIC analysis.

Ribociclib as First-Line Therapy for HR-Positive, Advanced Breast Cancer

Insights Into Breast Cancer in the East vs the West: A Review

Predictors of Hand-Foot Syndrome and Pyridoxine for Prevention of Capecitabine-Induced Hand-Foot Syndrome: A Randomized Clinical Trial.

Breast cancer in women with neurofibromatosis type 1 (NF1): a comprehensive case series with molecular insights into its aggressive phenotype.

Elucidating therapeutic molecular targets in premenopausal Asian women with recurrent breast cancers.

Outcomes in breast cancer-does ethnicity matter?

Potential value of ctDNA monitoring in metastatic HR + /HER2 - breast cancer: longitudinal ctDNA analysis in the phase Ib MONALEESASIA trial.

Contrasting Epidemiology and Clinicopathology of Female Breast Cancer in Asians vs the US Population.

Adjuvant aromatase inhibitors for early breast cancer after chemotherapy-induced amenorrhoea: caution and suggested guidelines.

Exploiting metabolic vulnerabilities in breast cancers with NF1 loss.

Genotype-Phenotype Correlation in NF1: Evidence for a More Severe Phenotype Associated with Missense Mutations Affecting NF1 Codons 844-848.

Effects of housing value and medical subsidy on treatment and outcomes of breast cancer patients in Singapore: A retrospective cohort study.

Ribociclib, a CDK 4/6 inhibitor, plus endocrine therapy in Asian women with advanced breast cancer.

Emerging systemic therapy options beyond CDK4/6 inhibitors for hormone receptor-positive HER2-negative advanced breast cancer

Whole-exome sequencing of breast cancer, malignant peripheral nerve sheath tumor and neurofibroma from a patient with neurofibromatosis type 1.

Brain metastases in Asian HER2-positive breast cancer patients: anti-HER2 treatments and their impact on survival.

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