Directory

Singapore’s President Science Award

NRF Singapore,2021

Elected Fellow of the American Academy of Microbiology

American Society For Microbiology,2021

His current research has two major focuses: 

1) Virology and emerging infectious diseases: Professor Wang played a leading role in identifying bats as the natural host of the Severe Acute Respiratory Syndrome (SARS) virus. In response to COVID-19 outbreak, his team made several contributions including the development of antibody based serological tests, investigation of the origin of SARS-CoV-2 and cross-special transmission, and development of novel vaccination strategy to broaden protective immunity against future variants and emerging SARS-related coronaviruses.  

2) Bat biology and bat immunology: Professor want extended his bat-virus research to better understanding virus-bat interaction and he co-existence of bats with a large number of viruses without developing clinical diseases. He is a pioneer in bat immunology and his team discovered multiple mechanisms from bats which are responsible for their unique disease-resistance phenotypes. This research has led to new opportunities beyond infectious diseases and his team is now conducting bat-inspired research into inflammatory, metabolic, neurological and other disease areas. 

Bat ASC2 suppresses inflammasomes and ameliorates inflammatory diseases.

Cell – Ahn Matae; Chen Vivian Chih-Wei; Rozario Pritisha; Ng Wei Lun; Kong Pui San; Sia Wan Rong; Kang Adrian Eng Zheng; Su Qi; Nguyen Lan Huong; Zhu Feng; Chan Wharton O Y; Tan Chee Wah; Cheong Wan Shoo; Hey Ying Ying; Foo Randy; Guo Fusheng; Lim Yan Ting; Li Xin; Chia Wan Ni; Sobota Radoslaw M; Fu Nai Yang; Irving Aaron T; Wang Lin-Fa (2023)

186 (10); 2144-2159.e22

Single-cell transcriptome analysis of the in vivo response to viral infection in the cave nectar bat Eonycteris spelaea.

Immunity – Gamage Akshamal M; Chan Wharton O Y; Zhu Feng; Lim Yan Ting; Long Sandy; Ahn Matae; Tan Chee Wah; Hiang Foo Randy Jee; Sia Wan Rong; Lim Xiao Fang; He Haopeng; Zhai Weiwei; Anderson Danielle E; Sobota Radoslaw Mikolaj; Dutertre Charles-Antoine; Wang Lin-Fa (2022)

55 (11); 2187-2205.e5

A Zoonotic Henipavirus in Febrile Patients in China

N Engl J Med – Zhang X-A, Li H, Jiang F-C, Zhu F, Zhang Y-F, Chen J-J, Tan C-W, Anderson DE, Fan H, Dong L-Y, Li C, Zhang P-H, Li Y, Ding H, Fang L-Q, Wang L-F, Liu W (2022)

Pan-Sarbecovirus Neutralizing Antibodies in BNT162b2-Immunized SARS-CoV-1 Survivors.

N Engl J Med – Tan CW, Chia WN, Young BE, Zhu F, Lim BL, Sia WR, Thein TL, Chen MI, Leo YS, Lye DC and Wang L-F (2021)

Translation from bats to humans beyond infectious diseases.

J Exp Med – Ahn M and Wang L-F (2021)

Lessons from the host defences of bats, a unique viral reservoir.

Nature 589 – Irving A, Ahn M, Goh G, Anderson AE, Wang L-F (2021)

A SARS-CoV-2 surrogate virus neutralization test based on antibody-mediated blockage of ACE2-spike protein-protein interaction.

Nat BioTech – Tan CW, Chia WN, Qin X, Liu P, Chen MI-C, Tiu C, Hu Z, Chen VC-W, Young BE, Sia WR, Tan Y-J, Foo R, Yi Y, Lye DC, Anderson DE, Wang, L.-F  (2020)

From Hendra to Wuhan: what has been learned in responding to emerging zoonotic viruses.

Lancet 395 – Wang L-F, Anderson DE, Mackenzie JS, Merson MH (2020)

Comparative analysis of bat genomes provides insight into the evolution of flight and immunity.

Science (New York, N.Y.) – Zhang Guojie; Cowled Christopher; Shi Zhengli; Huang Zhiyong; Bishop-Lilly Kimberly A; Fang Xiaodong; Wynne James W; Xiong Zhiqiang; Baker Michelle L; Zhao Wei; Tachedjian Mary; Zhu Yabing; Zhou Peng; Jiang Xuanting; Ng Justin; Yang Lan; Wu Lijun; Xiao Jin; Feng Yue; Chen Yuanxin; Sun Xiaoqing; Zhang Yong; Marsh Glenn A; Crameri Gary; Broder Christopher C; Frey Kenneth G; Wang Lin-Fa; Wang Jun (2013)

339 (6118); 456-60

Bats are natural reservoirs of SARS-like coronaviruses.

Science (New York, N.Y.) – Li Wendong; Shi Zhengli; Yu Meng; Ren Wuze; Smith Craig; Epstein Jonathan H; Wang Hanzhong; Crameri Gary; Hu Zhihong; Zhang Huajun; Zhang Jianhong; McEachern Jennifer; Field Hume; Daszak Peter; Eaton Bryan T; Zhang Shuyi; Wang Lin-Fa (2005)

310 (5748); 676-9