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Tan Ah Moy

Clinical Associate Professor

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Bio Research Publications

Education Qualifications: MBBS, MMed (Paeds), FAM, FRCP (EDIN)

Assoc Prof Tan Ah Moy received her MBBS from National University of Singapore(NUS) in 1973. She passed her Master of Medicine (Paediatric) NUS in 1977. She received her postgraduate training in Paediatric Hematology/Oncology from Royal Children's Hospital, Melbourne under Ministry of Health Scholarship in 1986. Upon returning she has been actively involved in expansion and development of childhood cancer care in Singapore. She was a member of National Cancer Care Committee from 2000 to 2004. She was appointed as Adjunct Associate Professor in YLL School of Medicine in 2006 and subsequently as Clinical Associate Professor, Duke -NUS Medicine School and Lee Kong Chian School of Medicine.

From 1997 to 2012 she was appointed Head of Paediatric Hematology/Oncology Service in KKH. During her headship, KKH provided comprehensive programme for treatment of childhood cancer and blood disorders in Singapore. The Singapore Childhood Cancer Registry was started in 1997 and she is Director of SCCR. SCCR has a comprehensive internet enabled data repository and supports many research projects in childhood cancer. As Director of Hematopoietic Stem Cell Transplant& Cell Therapy  in KKH and also a member of SingHealth-Duke  Transplant Center and Viva-Asia BMT Consortium, she actively led the programme in research. She is involved in training clinical fellows from the region.

Professional Appointments and Committee Memberships:

  • Adjunct Associate Professor, Yong Loo Lin School of Medicine
  • Clinical Associate Professor, Duke - NUS Medical School Singapore
  • Adjunct Associate Professor, Lee Kong Chian School Of Medicine
  • Senior Consultant, Department of Paediatrics Subspecialties, Paediatric Hematology/Oncology Service, KKH -2012 to Present
  • Programme Director of Hematopoietic Stem Cell Transplant  & Cell Therapy ,KKH 1998 to present
  • Head of Paediatric Hematology/Oncology Service KKH 1997 - 2012
  • Director of Singapore Childhood Cancer Registry 2005 to present

Awards:

  • Outstanding Clinician Award, GCEO Excellence Award 2018
  • National Day Long Service Award 2010
  • Singapore Health Quality Service Award –GOLD 2020, 2022
  • Service from the Heart, KKH 2000, 2004, 2006, 2007, 2009, 2011, 2013, 2015
  • Excellent Service Award Star 2005, 2012
  • Long Service Award KKH 2005, 2014
  • Best clinical research paper oral, Combined Scientific Meeting, Singhealth and National Health Group, 2005
  • Best poster award, Singapore-Malaysia Congress of Med. 2002
  • HMDP Fellowship in Paediatric Haematology/Oncology, Royal Children's Hospital. Melbourne 1 year 1986
  • HMDP Fellowship in Cancer Survivorship , Toronto Sick Kids Hospital,2018

Research Interests:

  • Blood and Marrow Transplantation & Cell Therapy  in Children
  • Cancer in Adolescent
  • Childhood Cancer Survivorship

Selected Publications:

Haploidentical Hematopoietic Cell Transplantation of Ex Vivo Tcrαβ-Depleted Grafts with CD45RA-Depleted Memory T Cell Add-Back Reduces Chronic Graft-Versus-Host Disease and Results in Favourable Gvhd-Relapse Free Survival: 5-Year Follow-up of 107 Patients Treated in a Multicenter Study in Singapore Blood  2022 Y. C. Linn, Y. L. Boo, R. Bhattacharyya, LP Koh Z. Y. Lim, M. Poon, M. S. F. Seng, P. L. Tan, C. Phipps, B. Vellayappan, A. M. Tan, L. K. Tan, Y. S. M. Loh, T. G. Soh, G. Gan, Y. J. Koh, W. H. Leung YC Linn. Blood (2022) 140 (Supplement 1): 4707–4708.

"T-CELL RECEPTOR REPERTOIRE DIVERSITY AND L-ASPARAGINASE HYPERSENSITIVITY IN CHILDHOOD ACUTE LYMPHOBLASTIC LEUKEMIA." HemaSphere 6: 463-464.2022  Euro JC July 2022 A Yeoh, Lee S ,   Z. Li, E Lim, E. Chiew, H. Ariffin ,A. M. Tan, , J. J. Yang 

Life-threatening infections during treatment for acute lymphoblastic leukemia on the Malaysia-Singapore 2003 and 2010 clinical trials: A risk prediction model. Bernice Oh,L Fan,S Lee KM Foo, Joyce Lam, Ah Moy Tan Allen Yeoh    Asia-Pac J Clin Oncol. 2022;18:e456–e468

“Transcriptome-wide subtyping of pediatric and adult T cell acute lymhoblastic leukemia in an international study of 707 cases.”  Dai Y T, F Zhang, H Fang J F Li, G Lu, L Jiang, B Chen, D Mao, Y F Liu, J Wang L J Peng, C Feng, H F Chen, J X Mu, Q L Zhang, H Wang, H Ariffin, A. M. Tan, J H Wang, Y J Lou, S N Chen, Q Wang, H Liu, Z Shan, I Matsumura, Y Miyazaki, T Yasuda, L P Dou, X J Yan,  S Yan, A E Yeoh, D P Wu, H Kiyoi, F Hayakawa, J Jin, S Y Wang, X J Sun, J Q Mi, Z Chen,doi 10.1073/pnas.2120787119 April2022.PNAS 2022 Vol. 119 No. 15 e2120787119 https://doi.org/10.1073/pnas.2120787119

Association of genetic ancestry with the molecular subtypes  and prognosis of childhood acute lymphoblastic leukemia Lee SHR,Antillon-Klussmann ,  D Pei, FP Yang ,Lin HP , Tan AM , Arriffin H , Cheng C , Evans W E , Stephen P H,Mignon L Allen Y , CH Pui  JAMA Onco.2022 Jan 27.doi:10.1001/jamaonco.2021.6826 online  

"Total Lymphatic Irradiation as Part of Conditioning in Pediatric Hematopoietic Stem Cell Transplantation: A Single Institution Experience From a Radiation Oncology Perspective." Wong, R. X., P. R. Iyer, A. Ong, R. Bhattacharyya, W. S. Looi, M. Seng, M. Y. Chan, K. Vijayakumari, T. N. A. Pham, W. H. Leung and A. M. Tan. International Journal of Radiation Oncology Biology Physics 2021 111(3): e178

The Impact of Genetic Ancestry on the Biology and Prognosis of Childhood Acute Lymphoblastic Leukemia Lee, S., F. Antillon, D. Pei, W. Yang, K. G. Roberts, Z. Li, M. Devidas, W. Yang, C. Najera, H. P. Lin, A. M. Tan, H. Ariffin, C. Cheng, W. E. Evans, S. P. Hunger, S. Jeha, C. G. Mullighan, M. L. Loh, A. E. Yeoh, C. H. Pui and J. J. Yang (2021). "." Clinical Lymphoma, Myeloma and Leukemia 2021: S263.

Practical Considerations for Using RNA Sequencing in Management of B-Lymphoblastic Leukemia: Ma-Spore ALL-Seq 2020 Implementation Strategy Chin, W. H. N., Z. Li, N. Jiang, E. H. Lim, J. Y. S. Lim, Y. Lu, K. H. Chiew, S. K. Y. Kham, B. L. Z. Oh, A. M. Tan, H. Ariffin, J. J. Yang and A. E. Yeoh "J Mol Diagn. 2021 Aug 6:S1525-1578(21)00237-3. doi: 10.1016/j.jmoldx.2021.07.013. Epub ahead of print. PMID: 34365011

Intracellular vincristine levels in lymphoblasts affect treatment outcome in childhood B-acute lymphoblastic leukemia :Ma-Spore ALL 2010 Study(MP-00417-20.R1- BJCPharma 2021;87:1990-1999  Jiang N, Wang LZ, Xiang XQ ,E Chew   How SL ,Lin HP,  Tan A M,TC Quah, Gog BC, Hany Arriffin,, Allen Yeoh 

Identifying IGH disease clones for MRD monitoring childhood B-cell acute lymphoblastic leukemia using RNA-Seq  Zhenhua Li, E Lim,Winnie Chin, KH Chew, S Kow , TC Quah, HP Lin, AM Tan, H Arriffin , J Yang , Allen Yeoh  Leukemia   (2020 )34:2418-2429 

Excellent survival outcomes of paediatric patients with acute myeloid leukemia treated with MASPORE 2006 protocol Sutiman Natalia, Nwe, Mya, Lai Eunice, Lee Denyse, Chan Mei Yoke, Yeoh Allen, Soh Shui Yen, Leung Wing,Tan Ah Moy Clin Lymphoma Myeloma Leuk 2020;3:2418-2429

Childhood chronic myeloid leukemia in Singapore: Is there a role for hematopoietic stem cell transplantation in the TKI era? Ah Moy Tan, Mya Soe Nwe, Vijayakumari K, Mei Yoke Chan, Vinod Gunasekaran, Prasad Iyer & Poh Lin Tan  EBMT  March 2019 Frankfurt P094 Page 204 - Bone Marrow Transplantation (2019) 54:144–619

Whole-genome noncoding sequence analysis in T cell acute lymphoblastic leukemia identify oncogene enhancer mutations. Blood 2017 129: 33264-68;doi: https//dol. org 1 0 .1182/blood-2017 -03- 771 162 SY Hu, MX Qian,H Zhang, Y Guo,Y Yang, S Kow, TC Quah, AM Tan, A Yeoh, CH Pu i, JJ Yang

Critically ill children with hemaphagocytic lymphohistiocytosis: A case Series of 14 patients. HM Leow, SH Soh, AM Tan, YH Mok, JH Lee J Pediatr Hematol Oncol,vol 39 no 6 Aug 2017 e303-e306

Whole Transcriptome sequencing identified a distinct subtype of ALL with predominant genomic abnormalities of EP300 and CREBBP Genome Res 2016 Nov 30.pii gr 209163.116 Maoxiang Q, Hui Z ,Shirley K, AM Tan, Hany A ,Ching HP, Allen Y, Jun J Y

Management of a Kaposiform haemangioendothelioma of the kidney with Kasabach-Meritt phenomenon without chemotherapy. Mya SN, Amos Loh, AM Tan, J Lam, K Chang Paed Hemato & Oncology Journal 2017 89-92

Acute lymphoblastic leukemia in a child with a de novo germline gnb1 mutation M Brett,Angeline Lai, TW Tan, AM Tan, R Foo, Saumya J, EC Tan. AJMG Oct 2016 DOI:10.1002/ajmg.a.38026

Viva-Asia Blood and Marrow Transplantation groups - A survey of consortium activity over a 12 year period (2000 to 2011 ) AM Tan,C Ha, CF Li, G Chan, V lee, PL Tan, S Hongeng, K Sanakit,A Lee,HP Lin, MRosario, J Chen. Annals 201 6;45:3: 106-9

TCR αβ and CD 19 - depleted haploidentical stem cell transplant with reduced intensity conditioning for Hoyeraai-Hredarsson Syndrome with RTEL 1 mutation R Bhattacharyya, AM Tan, MY Chan ,SS Janur, R Foo, P lyer BMT 2016;51 :753-4

Minimal residual disease-guided treatment deintensification for children with acute lymphoblastic leukemia: results from the Malaysia-Singapore Acute Lymphoblastic Leukemia 2003 study. - Yeoh AE, Ariffin H, Chai EL, Kwok CS, Chan YH, Ponnudurai K, Campana D, Tan PL, Chan MY, Kham SK, Chong LA, Tan AM, Lin HP, Quah TC. JCO 2012,30:19:2384-2392