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Chan Kok Yen, Jerry

Professor

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Bio Research Publications

Education Qualifications: MB BCh BaO (Hons), MA MRCOG FRCOG PhD FAMS (OBGYN & Clinician Scientist)

Professor Chan read Medicine at Trinity College Dublin, graduating with Honours and first in his class in 1997. He began his postgraduate residency in England, mainly in Manchester and London. He completed the rest of his OBGYN training in Singapore in 2009, and a fellowship in Reproductive Endocrinology and Infertility in 2011, and is a practising accredited specialist in in Assisted Reproductive Technique in KK Women's and Children Hospital. He is a fellow of the Royal College of Obstetrician and Gynaecologist in London.

Professor Chan completed a PhD in intrauterine stem cell therapies at Imperial College London. Thereafter, he returned to Singapore and started the Experimental Fetal Therapy laboratory, with a primary focus in developing novel fetal molecular therapies in the form of gene transfer and stem cell transplantation. Since then, he has been continuously funded by major grant funding bodies for his research, and has supervised over 12 PhD students successfully. He has published over 170 papers, including prestigious journals such as The Lancet, Nature, Cell, Science, Immunity, PNAS, Blood, Stem Cells among others. 

 

Professional Appointments and Committee Memberships:

  • Associate Professor (Joint), Principal Investigator - Experimental Fetal Medicine Group, Yong Loo Lin School of Medicine, NUS, Singapore
  • Associate Professor (Honorary), University of Queensland Centre for Clinical Research, University of Queensland, Australia
  • Adjunct Principal Investigator, Singapore Immunology Network, A*STAR, Singapore
  • Member, Board of Academy of Medicine, Clinician Scientist, 2017 – Present
  • Member, Academic Medicine Education Institute, 2013 – Present
  • Member, SingHealth Grant Review Committee – Clinical, 2012 – Present
  • Mentor, SingHealth OBGYN Residency Clinician-Scientist Track, 2010 – Present
  • Member – Singapore Stem Cell Consortium, 2010 – Present

Awards:

  • NMRC Clinician Scientist Award (Senior Investigator), 2017-2021
  • Singapore Health Quality Service – Star Award, 2017
  • Singapore Health Quality Service – Silver Award, 2014
  • Distinguished Researcher Award – SingHealth Excellence Awards, Singapore, 2013
  • 22nd Benjamin Henry Sheares Memorial Lecture. Intrauterine Stem Cell Transplantation and Gene Therapy. OGSS. Singapore International Congress of Obstetrics and Gynaecology, 2011
My research interests are in the characterisation of fetal stem cells, such as mesenchymal stem cells, haemopoietic stem cells, endothelial progenitor cells and neural stem cells, and developing their translational use for both fetal and post-natal therapy, and in tissue engineering through studies of directed differentiation, homing and migration, and cell-cell interactions. We work with small and large animal models of different diseases and inherited conditions through xeno-transplantation, and utilise transcriptomics, proteomics and micro-fluidics approaches to delineate stem cell potency and interactions with other cell types of interest. Derivation of cGMP mesenchymal stem cells for bone repair and fetal transplantation is being developed.
 
Another area of research is into fetal gene transfer with non-human primates, allowing both safety and efficacy of such approaches to be assessed in the only animal model which approximates human fetal ontogeny and placentation.
 
Clinical research interests encompasses reproductive medicine in areas such as fertility preservation, development of novel ovarian reserve biomarkers and delineating the pathogenesis of endometriosis through application of tissue engineering principles and biosensing technologies.

Selected Publication:

See Ling Loy, Poh Hui Wee, Marjorelee T Colega, Yin Bun Cheung, Izzuddin M Aris, Jerry Kok Yen Chan, Keith M Godfrey, Peter D Gluckman, Kok Hian Tan, Lynette Pei-Chi Shek, Yap Seng Chong, Padmapriya Natarajan, Falk Muller-Riemenschneider Ngee Lek, Victor Samuel Rajadurai, Mya-Thway Tint, Yung Seng Lee, Mary Foong-Fong Chong, Fabian Yap. Maternal night-fasting interval during pregnancy Is assoicated with neonatal head circumference and adiposity. Journal of Nutrition. 2017 IN PRESS. IF. 3.9

Poon Nian Lim, Jason Feng, Zuyon Wang, Mark Chong, Toshiisa Konishi, Lay Geok Tan, Jerry Chan, Eng San Thian. In-vivo evaluation of subcutaneously implanted cell-loaded apatite microcarriers for osteogenic potency. Journal of Material Science: Materials in Medicne. 2017 Jun;28(6):86. IF 2.3

Peter See, Charles-Antoine Dutertre, Jinmiao Chen, Patrick Günther, Naomi McGovern, Sergio Erdal Irac, Merry Gunawan, Marc Beyer, Kristian Händler, Kaibo Duan, Hermi Rizal Bin Sumatoh, Nicolas Ruffin, Mabel Jouve, Ester Gea-Mallorquí, Raoul C.M. Hennekam, Tony Lim, Chan Chung Yip, Ming Wen, Benoit Malleret, Ivy Low, Nurhidaya Binte Shadan, Charlene Foong Shu Fen, Alicia Tay, Josephine Lum, Francesca Zolezzi, Anis Larbi, Michael Poidinger, Jerry K.Y. Chan, Qingfeng Chen, Laurent Renia, Philippe Benaroch, Andreas Schlitzer, Joachim L. Schultze, Evan W. Newell, Muzlifah Haniffa and Florent Ginhoux. Mapping the human DC lineage through the integration of high dimensional techniques. Science 2017 (IN PRESS) IF 34.7

Yung CF, Tam C, Rajadurai VS, Chan JKY, Low MSF, Ng YH, Thoon KC, Tan LK. Rapid assessment of clinical specialty awareness of Zika virus knowledge and guidelines in Singapore. PLoS Current Outbreaks 2017 (IN PRESS)

Naomi McGovern, Amanda Shin, Gillian Low, Donovan Low, Kaibo Duan, 
 Leong Jing Yao, Rasha Msallam, Ivy Low, Nurhidaya Binte Shadan, Hermi R 
Sumatoh, Erin Soon, Josephine Lum, Esther Mok, Sandra Hubert, Peter See, 
Edwin Huang Kunxiang, Mahesh Choolani, Citra Nurafah Zaini Mattar, Fan Yiping, Tony Kiat Hon Lim, John Kit Chung Tam, Christopher Schuster, 
Adelheid Elbe-Bürger, Michael Poidinger, Xiao Wang8, Venetia Bigley, 
Matthew Collin, Muzlifah Haniffa, Salvatore Albani, Anis Larbi, Evan W Newell, Jerry Kok Yen Chan* and Florent Ginhoux*. 
Human fetal dendritic cells promote pre-natal T cell immune-suppression through Arginase 2 activity. Nature 2017 IN PRESS. *Joint Last and Corresponding Author. IF 38.1 DOI: 10.1038/nature22795

Ruban R P Durairaj, Yie Hou Lee, Yojiro Maruyama 1, Miriam N. Baumgarten, Bruce Campbell, Siobhan Quenby, Jerry K Y Chan, Nick Raine-Fenning, Jan J Brosens, Lukasz Polanski. Deregulation of the endometrial stromal cell secretome precedes embryo implantation failure in IVF. Molecular Human Reproduction 2017 Apr 10 (Epub). IF 3.7

Jun S Lai, Wei Wei Pang, Shirong Cai, yung Seng Lee, Jerry K Y Chan, Lynette PC Shek, Fabian KP Yap, Kok Hian Tna, Keith M Godfrey, Rob M van Dam, Yap Seng Chong, Marry F F Chong. High folate and low vitamin B12 status during pregnancy is associated with gestational diabetes mellitus. Clinical Nutrition 2017 Mar 24 Epub. IF 3.4

Tuck Seng Cheng, See Ling Loy, Yin Bun Cheung, Shirong Cai, Marjorelee T. Colega, Keith M. Godfrey, Yap-Seng Chong, Kok Hian Tan, Lynette Pei-Chi Shek, Yung Seng Lee, Ngee Lek, Jerry Kok Yen Chan, Mary Foong-Fong Chong, Fabian Yap. Plasma vitamin D status is associated with poor sleep quality and night-time eating at mid-pregnancy in Singapore. Nutrients with behavioral circadian rhythms during pregnancy. Nutrients 2017 IF 3.8

Youshan Melissa Lin, Ph.D.; Jialing Lee, MPhil; Jessica Fang Yan Lim, BSc, BMed; Mahesh Choolani, MBBS, PhD; Jerry Kok Yen Chan, MBBS, PhD; Shaul Reuveny, PhD; Steve Kah Weng Oh, PhD. Critical attributes of human early mesenchymal stromal cells-laden microcarrier constructs for improved chondrogenic differentiation. Stem Cells Research and Therapy 2017 May 8;8(1):93. IF 4.2

Citra Mattar, Irene Gil-Farina, Cecilia Rosales, Nuryanti Johana, Yvonne Yi Wan Tan, Jenny McIntosh, Christine Kaeppel, Simon N Waddington, Arijit Biswas, Mahesh Choolani, Manfred Schmidt, Amit C Nathwani, Jerry KY Chan. In-utero transfer of adeno-associated vectors produces long-term Factor IX levels in a cynomolgus macaque model. Molecular Therapy 2017 Apr 24 ePUB IF 6.9

See Ling Loy, Michelle Jia Hui Ng, Yin Bun Cheung, Keith M. Godfrey, Philip C. Calder, Ngee Lek, Fabian Yap, Falk Müller-Riemenschneider, Padmapriya Natarajan, Yap-Seng Chong, Kok Hian Tan, Lynette Pei-Chi Shek, Mary Foong-Fong Chong, and Jerry Kok Yen Chan. Plasma omega-3 fatty acids in pregnancy are inversely associated with postpartum weight retention in a multi-ethnic Asian cohort. American Journal of Clinical Nutrition IN PRESS 2017 IF 6.8

Alan Tin-Lun Lam, Jian Li, Jessica Pei-Wen Toh, Eileen Jia-Hui Sim, Allen Kuan-Liang Chen, Jerry Kok-Yen Chan, Mahesh Choolani, Shaul Reuveny, William R. Birch, and Steve Kah-Weng Oh. Biodegradable poly-ε-caprolactone microcarriers for efficient production of human mesenchymal stem cells and secreted cytokines in stirred bioreactors. Cytotherapy. 2017;19:419-32. IF 3.6

Reinhold Jj. Medina, Chad l. Barber, Francoise Dignat-George, Juan M. Melero-Martin, Kiarash Khosrotehrani, Osamu Ohneda, Anna M. Randi, Jerry K.Y. Chan, M. Luisa Iruela-Arispe, Teruhide Yamaguchi, Victor van Hinsbergh, Mervin C. Yoder, Alan W. Stitt. Endothelial Progenitors: A Consensus Statement on Nomenclature. Stem Cell Translational Medicine (2017) Mar 10 Epub. IF. 5.7

Fok-Moon Lum, Donavan KS Low, Yiping Fan, Jeslin JL Tan, Bernett Lee, SIgN Immune-monitoring platform, Jerry KY Chan, Laurent Renia, Florent Ginhoux, Lisa FP Ng. Zika virus infects human brain fetal microglia and induces a strong inflammatory response. Clinical Infectious Diseases 2017 Apr 1;64(7):914-920. IF 8.9

Yannick Simoni, Michael Fehlings, Henrik Kloverpris, Naomi McGovern, Si-Lin Koo, Loh Chiew Yee, Shawn Lim, Ayako Kurioka, Joannah Fergusson, Choon- Leong Tang, Ming Hian Kam, Koh Dennis, Yong Jie Tao, Tony Lim Kiat Hon, Jerry K Y Chan, Maria Lafaille, Sriram Narayanan, Sonia Baig, Mohamed Shabeer, Sue-Anne Toh Ee Shiow, Henry Tan, Rosslyn Anicette, Tan Eng Huat, Angela Takano, Paul Klenerman, Alasdair Leslie, Daniel Tan, Iain Beehuat Tan, Florent Ginhoux, Evan Newell. Redefining human ILC using high dimensional single cell analysis. Immunity 2017 Jan 17;46(1):148-161. IF 24.1