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Chang Tou En Kenneth

Clinical Associate Professor

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Education Qualifications: MBChB, FRCPath

Dr. Kenneth Chang is senior consultant paediatric pathologist and Head of Department, Department of Pathology and Laboratory Medicine at KK Women’s and Children’s Hospital in Singapore. He is Adjunct Associate Professor at Duke-NUS Medical School, and Academic Vice-Chair for Clinical Service Innovation in the SingHealth Duke-NUS Pathology Academic Clinical Programme. He is Principal Investigator and Steering Committee member in the VIVA-KKH Paediatric Brain and Solid Tumours Programme. He is also Director of the SingHealth Tissue Repository and Advanced Molecular Pathology Laboratory, which are core research platforms in the SingHealth Academic Medical Centre. Since 2011, he has been Visiting Consultant at the Division of Forensic Medicine, Applied Sciences Group, Health Sciences Authority.

Dr. Chang trained in paediatric pathology at the Hospital for Sick Children in Toronto, Canada and University of Toronto, completing a 2-year clinical fellowship from 2007 to 2009. More recently in the summer of 2015, he was a visiting fellow at the University of British Columbia and BC Cancer Agency. Currently, he is a Council Member in the International Paediatric Pathology Association and plays a role in outreach to paediatric pathologists in the Asia-Pacific region.

His research interests derive from his clinical responsibilities, and include molecular diagnostics in relation to paediatric cancers, paediatric sarcomas with a focus on BCOR-mutated sarcomas, and placental pathology. He has published more than 95 scientific articles and 5 book chapters.

Research Interests: Molecular diagnostics in relation to paediatric cancers, paediatric sarcomas with a focus on BCOR-mutated sarcomas, placental pathology

Selected Publications:

Chang KTE, Tay A, Kuick CH, Chen HY, Algar E, Taubenheim N, Campbell J, Mechinaud F, Campbell M, Super L, Chantranuwat C, Yuen ST, Chan JKC, Chow CW. ALK-positive histiocytosis: an expanded clinicopathologic spectrum and frequent presence of KIF5B-ALK fusion. Modern Pathol 2019; 32: 598-608

Chang KTE, Goytain A, Tucker T, Karsan A, Lee CH, Nielsen TO, Ng T. Development and evaluation of a pan-sarcoma fusion gene detection assay using the NanoString nCounter platform. J Mol Diagnostics 2018; 20(1): 63-77

Chang KT, Keating S, Costa S, Machin G, Kingdom J, Shannon P. Third-trimester stillbirths: correlative neuropathology and placental pathology. Pediatr Dev Pathol. 2011 Sep-Oct;14(5):345-52

Chang KT, Taylor GP, Meschino WS, Kantor PF, Cutz E. Mitogenic cardiomyopathy: a lethal neonatal familial dilated cardiomyopathy characterized by myocyte hyperplasia and proliferation. Hum Pathol. 2010 Jul;41(7):1002-8

• Zhao ML, Yin MZ, Kuick CH, Chen HY, Aw SJ, Merchant K, Ng EHQ, Gunaratne S, Loh AHP, Gu WZ, Tang HF, Chang KTE. Congenital mesoblastic nephroma is characterized by kinase mutations including EGFR internal tandem duplications, ETV6-NTRK3 fusion, and rare KLHL7-BRAF fusion. Histopathol (in press)

• Wong MK,  Ng CCY, Kuick CH, Aw SJ, Rajasegaran V, Lim JQ, Sudhanshi J, Loh E, Yin MZ, Ma J, Zhang ZD, Iyer P, Loh AHP, Lian DWQ, Wang S, Goh SGH, Lim TH, Lim AST, Ng T, Goytain A, Loh AHL, Tan PH, Teh BT, Chang KTE. Clear cell sarcomas of kidney are characterized by BCOR gene abnormalities including exon 15 internal tandem duplications and BCOR-CCNB3 gene fusion. Histopathol 2018; 72: 320-329

• Aw SJ, Wang S, Loh AH, Kuick CH, Lian DW, Yong MH, Ling S, Peh GL, Soh SY, Loh AH, Tan PH, Chang KT. Novel karyotypes and cyclin D1 immunoreactivity in clear cell sarcoma of the kidney. Pediatr Dev Pathol. 2015; 18(4): 297-304 

• Shenje LT, Andersen P, Halushka MK, Lui C, Fernandez L, Collin GB, Amat-Alarcon N, Meschino W, Cutz E, Chang K, Yonescu R, Batista DA, Chen Y, Chelko S, Crosson JE, Scheel J, Vricella L, Craig BD, Marosy BA, Mohr DW, Hetrick KN, Romm JM, Scott AF, Valle D, Naggert JK, Kwon C, Doheny KF, Judge DP. Mutations in Alström protein impair terminal differentiation of cardiomyocytes. Nat Commun. 2014; 4: 3416

• Yao X, Tan J, Lim K, Koh J, Ooi WF, Li Z, Huang D, Xing M, Chan YS, Qu J, Tay ST, Wijaya G, Lam YN, Hong J, Lim APL, Guan P, Ng M, He C, Lin JS, Nandi T, Qamra A, Xu C, Myint SS, Davis J, Goh JY, Loh G, Tan B, Rozen S, Yu Q, Tan IBH, Cheng C, Li S, Chang K, Tan PH, Silver D, Lezhava A, Steger G, Hughes J, Teh BT, Tan P.  VHL deficiency drives enhancer activation of oncogenes in clear cell renal cell carcinoma. Cancer Discovery 2017; 7(11): 1284-1305

• Thompson EM, Hielscher T, Bouffet E, Remke M, Luu B, Gururangan S, McLendon RE, Bigner DD, Lipp ES, Perreault S, Cho YJ, Grant G, Kim SK, Lee JY, Rao AA, Giannini C, Li KK, Ng HK, Yao Y, Kumabe T, Tominaga T, Grajkowska WA, Perek-Polnik M, Low DC, Seow WT, Chang KT, Mora J, Pollack IF, Hamilton RL, Leary S, Moore AS, Ingram WJ, Hallahan AR, Jouvet A, Fèvre-Montange M, Vasiljevic A, Faure-Conter C, Shofuda T, Kagawa N, Hashimoto N, Jabado N, Weil AG, Gayden T, Wataya T, Shalaby T, Grotzer M, Zitterbart K, Sterba J, Kren L, Hortobágyi T, Klekner A, László B, Pócza T, Hauser P, Schüller U, Jung S, Jang WY, French PJ, Kros JM, van Veelen MC, Massimi L, Leonard JR, Rubin JB, Vibhakar R, Chambless LB, Cooper MK, Thompson RC, Faria CC, Carvalho A, Nunes S, Pimentel J, Fan X, Muraszko KM, López-Aguilar E, Lyden D, Garzia L, Shih DJ, Kijima N, Schneider C, Adamski J, Northcott PA, Kool M, Jones DT, Chan JA, Nikolic A, Garre ML, Van Meir EG, Osuka S, Olson JJ, Jahangiri A, Castro BA, Gupta N, Weiss WA, Moxon-Emre I, Mabbott DJ, Lassaletta A, Hawkins CE, Tabori U, Drake J, Kulkarni A, Dirks P, Rutka JT, Korshunov A, Pfister SM, Packer RJ, Ramaswamy V, Taylor MD. Prognostic value of medulloblastoma extent of resection after accounting for molecular subgroup: a retrospective integrated clinical and molecular analysis. Lancet Oncol. 2016 Apr;17(4):484-95