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Charumathi Sabanayagam

Associate Professor

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Bio Research Publications

Charumathi Sabanayagam is a Clinician Scientist and the Deputy Head of Ocular Epidemiology at the Singapore Eye Research Institute (SERI) and an Associate Professor with the EYE-ACP and the Centre for Quantitative Medicine at Duke-NUS Medical School, Singapore. She has a multi-disciplinary training in Medicine, Epidemiology, and Biostatistics. She received her medical degree (MBBS) from University of Madras, MD from The Tamil Nadu Dr. MGR Medical University, India, Masters in Public Health (M Med) and PhD both from the National University of Singapore. She completed her postdoctoral training in diabetes and cardiovascular epidemiology at the University of West Virginia, USA. She received the NMRC Transition Award in 2012, Khoo Mentored Research award in 2015 and serves as a key co-investigator in several other national grants and research programmes including the Diabetes studY in Nephropathy And other Microvascular cOmplications (DYNAMO) and the Singapore Epidemiology of Eye Diseases (SEED) study. She has published 190 papers in international peer reviewed journals (44 as first- and 34 as senior-author, Google Scholar H-Index of 40). She has mentored several fellows, residents, graduate and medical students in SERI and NUS. She received the SERI Best Mentor/Role Model Award in 2015.

Research Interest

Her current research focuses on the epidemiology, including burden, ethnic differences, risk factor contribution, and novel biomarkers of chronic kidney disease (CKD), diabetic retinopathy (DR), link between renal and retinal diseases and risk prediction using traditional and machine learning models.

 

  1. Teo ZL, Tham YC, Yu M, Cheng CY, Wong TY, Sabanayagam C. Do we have enough ophthalmologists to manage vision-threatening diabetic retinopathy? A global perspective. Eye (Lond). Jan 2020. [Epub ahead of print]

  2. Yang C, Kwak L, Ballew SH, Jaar BG, Deal JA, Folsom AR, Heiss G, Sharrett AR, Selvin E, Sabanayagam C, Coresh J, Matsushita K. Retinal microvascular findings and risk of incident peripheral artery disease: An analysis from the Atherosclerosis Risk in Communities (ARIC) Study. Atherosclerosis. Feb 2020;294:62-71.

  3. Sabanayagam C, Banu R, Chee ML, Lee R, Wang YX, Tan G, Jonas JB, Lamoureux EL, Cheng CY, Klein BEK, Mitchell P, Klein R, Cheung CMG, Wong TY. Incidence and progression of diabetic retinopathy: a systematic review. Lancet Diabetes Endocrinol. Feb 2019;7(2):140-149.

  4. Heng Wong MY, Tan NYQ, Sabanayagam C. Time trends, disease patterns and gender imbalance in the top 100 most cited articles in ophthalmology. Br J Ophthalmol. Jan 2019;103(1):18-25.

  5. Lim CC, Chee ML, Cheng CY, Kwek JL, Foo M, Wong TY, Sabanayagam C. Simplified end stage renal failure risk prediction model for the low-risk general population with chronic kidney disease. PLoS One. Feb 2019;14(2): e0212590.

  6. Sabanayagam C, Chee ML, Banu R, Cheng CY, Lim SC, Tai ES, Coffman T, Wong TY. Association of Diabetic Retinopathy and Diabetic Kidney Disease with All-Cause and Cardiovascular Mortality in a Multi-ethnic Asian Population. JAMA Netw Open. Mar 2019;2(3):e191540.

  7. Wong TY, Sabanayagam C. Strategies to Tackle the Global Burden of Diabetic Retinopathy: From Epidemiology to Artificial Intelligence. Ophthalmologica. Aug 2019 13:1-12.

  8. Sabanayagam C, Lye WK, Januszewski A, Banu Binte Mohammed Abdul R, Cheung GCM, Kumari N, Wong TY, Cheng CY, Lamoureux E. Urinary Isoprostane Levels and Age-Related Macular Degeneration. Invest Ophthalmol Vis Sci. May 2017;58(5):2538-2543.

  9. Yip W, Ong PG, Teo BW, Cheung CY, Tai ES, Cheng CY, Lamoureux E, Wong TY, Sabanayagam C. Retinal Vascular Imaging Markers and Incident Chronic Kidney Disease: A Prospective Cohort Study. Sci Rep. Aug 2017;7(1):9374.

  10. Sabanayagam C, Fenwick E, Ong PG, Tey ML, Tapp R, Cheng CY, Cheung GC, Aung T, Wong TY, Lamoureux E. Visual Impairment in Old and Very Old Community-dwelling Asian Adults. Ophthalmology. Nov 2016;123(11):2436-2438

  11. Annweiler C, Milea D, Whitson HE, Cheng CY, Wong TY, Ikram MK, Lamoureux EL, Sabanayagam C. Vitamin D insufficiency and cognitive impairment in Asians: a multi-ethnic population-based study and meta-analysis. J Intern Med. Sep 2016;280(3):300-11.

  12. Wong CW, Lamoureux EL, Cheng CY, Cheung GC, Tai ES, Wong TY, Sabanayagam C. Increased Burden of Vision Impairment and Eye Diseases in Persons with Chronic Kidney Disease - A Population-Based Study. EBioMedicine. Jan 2016 19;5:193-7.

  13. Sabanayagam C, Lye WK, Klein R, Klein BE, Cotch MF, Wang JJ, Mitchell P, Shaw JE, Selvin E, Sharrett AR, Wong TY. Retinal microvascular calibre and risk of diabetes mellitus: a systematic review and participant-level meta-analysis. Diabetologia.Nov 2015;58(11):2476-85.

  14. Lim CC, Teo BW, Ong PG, Cheung CY, Lim SC, Chow KY, Meng CC, Lee J, Tai ES, Wong TY, Sabanayagam C. Chronic kidney disease, cardiovascular disease and mortality: A prospective cohort study in a multi-ethnic Asian population. Eur J Prev Cardiol. Aug 2015;22(8):1018-26.

  15. Sabanayagam C, Khoo EY, Lye WK, Ikram MK, Lamoureux EL, Cheng CY, Tan ML, Salim A, Lee J, Lim SC, Tavintharan S, Thai AC, Heng D, Ma S, Tai ES, Wong TY. Diagnosis of diabetes mellitus using HbA1c in Asians: relationship between HbA1c and retinopathy in a multiethnic Asian population. J Clin Endocrinol Metab. Feb 2015;100(2):689-96.

  16. Seshasai S, Liao J, Toh QC, Cheng CY, Cheung CM, Sethi S, Wong TY, Sabanayagam C. Serum Leptin and Age-related Macular Degeneration. Invest Ophthalmol Vis Sci. Feb 2015, 56(3):1880-6.

  17. Yip W, Wong TY, Jonas JB, Zheng YF, Lamoureux E, Nangia V, Sabanayagam C. Prevalence, Awareness, and Control of Hypertension among Asian Indians living in Urban Singapore and Rural India. Journal of Hypertension, Aug 2013, 31(8):1539-46.

  18. Sabanayagam C, Wong TY, Xiao J, Shankar A. Serum cystatin C and prediabetes in non-obese US adults. Eur J Epidemiol. Apr 2013, 28(4):311-6.

  19. Shankar A, Teppala S, Sabanayagam C. Bisphenol A and peripheral arterial disease: results from the NHANES. Environ Health Perspect. Sep 2012;120(9):1297-300.

  20. Sabanayagam C, Shankar A, Klein BK, Lee KE, Muntner P et al. Bidirectional association of retinal vessel diameters and estimated glomerular filtration rate decline: The Beaver Dam CKD Study. Am J Kidney Dis. May 2011, 57(5):682-91.

  21. Sabanayagam C, Shankar A. The association between active smoking, smokeless tobacco, second-hand smoke exposure and insufficient sleep. Sleep Med, Jan 2011, 12(1):7-11.

  22. Sabanayagam C, Shankar A. Sleep duration and cardiovascular disease: results from the National Health Interview Survey. Sleep. Aug 2010;33(8):1037-42. 

  23. Sabanayagam C, Wong TY, Lim SC, Lee J, Shankar A, Tai ES. Ethnic disparities in prevalence and risk factors of chronic kidney disease. Nephrol Dial Transplant. Aug 2010, 25(8):2564-70.

  24. Sabanayagam C, Liew G, Tai ES et al. Relationship between glycated haemoglobin and microvascular complications: is there a natural cut-off point for the diagnosis of diabetes? Diabetologia, Jul 2009, 52(7):1279-8.

  25. Sabanayagam C, Shankar A, Koh D, Chia KS, Saw SM, Lim SC, Tai ES, Wong TY. Retinal microvascular caliber and chronic kidney disease in an Asian population. Am J Epidemiol, Mar 2009, 169(5):625-632.