Lee Cheng Jie Irene was a biochemist/cell biologist working extensively to characterize the underlying signal transduction involved in unfolded protein response, a homeostatic cascade activated to combat cellular stress. Failure to respond to cellular stress often results in cell death and the pathogenesis of human diseases. She has extensive research experience using gene-editing technology, RNA interference, immunoprecipitations, cell imaging, gene-array/ribosomal profiling and chemical genetic screening to dissect the molecular function of key proteins. Recently, with her strong passion in medical education, she is now an Assistant Professor in medical education in the MD Programme Department, Duke-NUS. Given her vast research experience, she is tasked to promote the improvement of preclinical education at Duke-NUS, i.e., the basic science curriculum. In addition, she will also be conducting educational research to encourage innovation and promote the science of education. She aims to combine her past experience and passion for teaching in promoting excellence in medical education.