Directory

PeiJu's research interests lie at the intersection of structural biology and computational biophysics, with a focus on understanding signaling pathways through the perspective of protein structures and dynamics. By leveraging protein simulations, I aim to gain deeper insights into conformational changes and interactions that drive cellular signaling events. Additionally, I am passionate about translating this knowledge into drug discovery, identifying novel small molecules that modulate these pathways for therapeutic purposes.

Ultra-large scale virtual screening identifies a small molecule inhibitor of the Wnt transporter Wntless.

iScience – Yu Jia; Liao Pei-Ju; Keller Thomas H; Cherian Joseph; Virshup David M; Xu Weijun (2024)

27 (8); 110454-na

Structural model of human PORCN illuminates disease-associated variants and drug-binding sites.

Journal of cell science – Yu Jia; Liao Pei-Ju; Xu Weijun; Jones Julie R; Everman David B; Flanagan-Steet Heather; Keller Thomas H; Virshup David M (2021)

134 (24); na-na

Discovery of the cancer cell selective dual acting anti-cancer agent (Z)-2-(1H-indol-3-yl)-3-(isoquinolin-5-yl)acrylonitrile (A131).

European journal of medicinal chemistry – See Cheng Shang; Kitagawa Mayumi; Liao Pei-Ju; Lee Kyung Hee; Wong Jasmine; Lee Sang Hyun; Dymock Brian W (2018)

156 344-367

Prodrugs of the cancer cell selective anti-cancer agent (Z)-2-(1H-indol-3-yl)-3-(isoquinolin-5-yl)acrylonitrile (A131) are orally efficacious in a mouse model of resistant colon cancer.

Bioorganic & medicinal chemistry letters – See Cheng Shang; Kitagawa Mayumi; Liao Pei-Ju; Lee Kyung Hee; Wong Jasmine; Lee Sang Hyun; Dymock Brian W (2019)

29 (2); 216-219

Dual blockade of the lipid kinase PIP4Ks and mitotic pathways leads to cancer-selective lethality.

Nature communications – Kitagawa Mayumi; Liao Pei-Ju; Lee Kyung Hee; Wong Jasmine; Shang See Cheng; Minami Noriaki; Sampetrean Oltea; Saya Hideyuki; Lingyun Dai; Prabhu Nayana; Diam Go Ka; Sobota Radoslaw; Larsson Andreas; Nordlund Pär; McCormick Frank; Ghosh Sujoy; Epstein David M; Dymock Brian W; Lee Sang Hyun (2017)

8 (1); 2200-na

A Ras-LSD1 axis activates PI3K signaling through PIK3IP1 suppression.

Oncogenesis – Lee Kyunghee; Kitagawa Mayumi; Liao Pei Ju; Virshup David M; Lee Sang Hyun (2020)

9 (1); 2-na

Opposing Activities of Aurora B Kinase and B56-PP2A Phosphatase on MKlp2 Determine Abscission Timing.

Current biology : CB – Fung Suet Yin Sarah; Kitagawa Mayumi; Liao Pei-Ju; Wong Jasmine; Lee Sang Hyun (2017)

27 (1); 78-86

The Tumor Suppressor Cdkn3 Is Required for Maintaining the Proper Number of Centrosomes by Regulating the Centrosomal Stability of Mps1.

Cell reports – Srinivas Vinayaka; Kitagawa Mayumi; Wong Jasmine; Liao Pei-Ju; Lee Sang Hyun (2015)

13 (8); 1569-77

Expression patterns of connexin 29 (GJE1) in mouse and rat cochlea.

Biochemical and biophysical research communications – Yang Jiann-Jou; Liao Pei-Ju; Su Ching-Chyuan; Li Shuan-Yow (2005)

338 (2); 723-8

Identification of mutations in members of the connexin gene family as a cause of nonsyndromic deafness in Taiwan.

Audiology & neuro-otology – Yang Jiann-Jou; Huang Shih-Hsin; Chou Kvei-Hsiu; Liao Pei-Ju; Su Ching-Chyuan; Li Shuan-Yow (2007)

12 (3); 198-208