Duke-NUS Medical School

Directory

Ong Choon Kiat

Associate Professor, SingHealth Duke-NUS Oncology Academic Clinical Programme

gmsock@nus.edu.sg

About

Academic Contributions

Professional

Research Interests

Teaching

Publications

Bio

Dr. Ong Choon Kiat is the Head of the Division of Cellular and Molecular Research and the Principal Investigator of Lymphoma Translational Research Laboratory, National Cancer Centre Singapore (NCCS). Concurrently, he also holds an appointment as an Associate Professor at the Duke-NUS Medical School. Recently, Dr. Ong is appointed as the Project Director for a National grant at the Fundeni Clinical Institute (FCI), Center of Excellence in Translational Medicine (CEMT), Romania. Dr. Ong obtained his BSc (Hon) in 2000 and PhD in 2006 from the National University of Singapore. During his post-doctoral training, Dr. Ong has led the genomic research in various cancers prevalent in Asia including lymphoma, cholangiocarcinoma and fibroepithelial tumors of the breast. He was also representing Singapore, leading the whole genome sequencing of T and NK-cell lymphoma in the International Cancer Genomic Consortium (ICGC). His research interest is to improve the clinical outcomes of cancer patients through the understanding of cancer genomics and translating the findings into clinical applications. Dr Ong, along with other collaborating scientists in the field of cancer research, was awarded the prestigious “AACR Team Science Award 2018” by the American Association for Cancer Research (AACR), recognising the outstanding interdisciplinary team’s work in furthering the knowledge of Asian prevalent cancers, contributing to the progress of cancer detection, treatment and prevention. He was also recently awarded the Outstanding Researcher Award (SingHealth GCEO Excellence Awards 2024).

Education

Doctor of Philosophy

National University of Singapore, Singapore

Bachelor of Science Hons Class 2A

National University of Singapore, Singapore

NUS Appointment(s)

Honours year student

Plant Engineering Laboratory, Department of Biological Sciences., 06/1999 - 06/2000

Directory

Bio

Education

Doctor of Philosophy

Bachelor of Science Hons Class 2A

NUS Appointment(s)

Honours year student

Academic Contribution(s)

Outstanding Researcher Award (SingHealth GCEO Excellence Awards 2024)

AACR Team Science Award

SingHealth Publish! Award (Outstanding)

SingHealth Publish! Award (Outstanding)

Outstanding Basic/Translational Research Award

Singapore Millennium Foundation (SMF) Scholarship Award

NUS-NMRC Young Scientist Award

Candidate for Novartis International Biotechnology Leadership Camp

Selected for Young Investigator’s Award (Basic Science)

Duke Appointment(s)

Assistant Professor

Professional Appointment(s)

Research Officer

Research Fellow

Senior Scientist

Junior Principal Investigator

Principal Investigator II

Senior Research Scientist

Principal Investigator I

Associate Professor

Acting Head

Project Director

Head

Membership

Member

Member

Member

Associate Member

Trainee Member

Research Interests

Teaching

Publications

Whole-genome sequencing identifies responders to Pembrolizumab in relapse/refractory natural-killer/T cell lymphoma.

A genomic-augmented multivariate prognostic model for the survival of natural-killer/T-cell lymphoma patients from an international cohort.

Aberrant JAK-STAT signaling-mediated chromatin remodeling impairs the sensitivity of NK/T-cell lymphoma to chidamide.

Super-enhancer-driven TOX2 mediates oncogenesis in Natural Killer/T Cell Lymphoma.

Oncogenic activation of the STAT3 pathway drives PD-L1 expression in natural killer/T-cell lymphoma.

Oncogenic activation of JAK3-STAT signaling confers clinical sensitivity to PRN371, a novel selective and potent JAK3 inhibitor, in natural killer/T-cell lymphoma.

Genomic and transcriptomic landscapes of Epstein-Barr virus in extranodal natural killer T-cell lymphoma.

Whole-genome sequencing reveals potent therapeutic strategy for monomorphic epitheliotropic intestinal T-cell lymphoma.

Single-cell landscape of idiopathic multicentric Castleman disease in identical twins.

Genetic risk of extranodal natural killer T-cell lymphoma: a genome-wide association study in multiple populations.

Genetic risk of extranodal natural killer T-cell lymphoma: a genome-wide association study.

JAK-STAT and G-protein-coupled receptor signaling pathways are frequently altered in epitheliotropic intestinal T-cell lymphoma.

Evaluation of the PIK3 pathway in peripheral T-cell lymphoma and NK/T-cell lymphoma.

Whole exome sequencing identifies recessive germline mutations in FAM160A1 in familial NK/T cell lymphoma.

Gene Expression Signatures for the Accurate Diagnosis of Peripheral T-Cell Lymphoma Entities in the Routine Clinical Practice.

Exome sequencing of liver fluke-associated cholangiocarcinoma.

Exome sequencing identifies distinct mutational patterns in liver fluke-related and non-infection-related bile duct cancers.

Genomic landscapes of breast fibroepithelial tumors.

Exome sequencing identifies highly recurrent MED12 somatic mutations in breast fibroadenoma.

Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma.

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