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Prakash Kumar Manharlal

Associate Professor

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Bio Research Publications

Education Qualifications: MBBS, M.Med (Internal Medicine), MRCP (United Kingdom), FRCP (Edinburgh), FRCP (Glasgow), FAMS (Neurology)

Dr Prakash Kumar obtained his undergraduate and postgraduate medical qualifications from Malaysia and subsequently underwent neurology specialist training in Singapore. Following that, he pursued a fellowship in Parkinson’s and Movement Disorders at Toronto Western Hospital, one of the largest and most reputable centres in North America. 

His areas of clinical and research interest include motor and non-motor problems in Parkinson’s disease and other Movement Disorders as well as Clinical Neurophysiology. He has published extensively in these areas.

 

Professional Appointments and Committee Memberships: 

  • Associate Professor and Research Mentor, Duke-NUS Medical School
  • Clinical Associate Professor, NUS Yong Loo Lin School of Medicine
  • Adjunct Associate Professor, Lee Kong Chian School of Medicine
  • Committee Member of International Association of Parkinsonism and Related Disorders (The Asian and Oceanic Educational Committee)
  • Member of International Movement Disorder Society
  • Committee member of Clinical Neurophysiology Society of Singapore

Awards:

  • AM-ETHOS Learning Enhancement And Progress (LEAP) award 2018
  • GCEO Excellence Awards, Outstanding Clinician Researcher Award 2018
  • Singhealth Graduate Medical Education, Program Director Service Appreciation Award 2017
  • AM-ETHOS Learning Enhancement And Progress (LEAP) award 2017
  • Gold Award by Singapore Productivity Association (SPA) for Team Excellence in Innovation and Quality Circles held on 11 Nov 2015
  • SingHealth Team-Based HMDP fellowship in Melbourne 2014
  • Service with A Heart Award winner April 2013 in Singapore General Hospital
  • Singapore Health Quality Service Award (SHQSA) 2013, Gold Award
  • National Neuroscience Institute, Singapore Long Service Award 2012
  • Service Quality Partners Award Winner in October 2010 for Singapore General Hospital
  • Service Quality Partners Award Winner in March 2009 for Singapore General Hospital
  • Ministry of Health HMDP Award for fellowship in Toronto 2007-2008

Leadership positions / roles in Education: 

  • Program Director (Neurology Senior Residency) SingHealth Residency 2012 - 2017

Research Interests:

  • Co-Investigator: Microbiome and Biomarkers in Parkinson’s disease. (CIRB: 2016/2834)
  • Site Principal Investigator: Real-time Freezing of Gait (FOG) detection and biofeedback device to facilitate rehabilitation in patients with Parkinsonism and related disorders. NUS – NNI Research Collaborative Grant $150,000. (CIRB: 2016/2743)
  • Principal Investigator: One-stop integrated care for Parkinson’s disease: A randomized crossover study. (CIRB: 2016/2467)
  • Co-Investigator: The role of monocytes in the pathogenesis of Parkinson’s disease. (CIRB: 2016/2182)
  • Principal Investigator: The impact of motor and non-motor symptoms on disability, falls and quality of life on people with Parkinson's disease. (CIRB: 2015/2835)
  • Co-Investigator. Pilot randomized controlled study of the efficacy of spinal magnetic stimulation for refractory constipation. (CIRB: 2015/2717)
  • Principal Investigator: The impact of non-motor symptoms Parkinson's disease on quality of life, economic and caregiver burden. Ministry of Health HSR grant $98,974. (HSRG12MAY007)
  • Co-Investigator. An open-label study to investigate the safety and the efficacy of rotigotine add-on therapy with low doses of pramipexole or ropinirole in patients with advanced Parkinson's disease. (Funded by EPS International 2012/13).
  • Co-Investigator. An open-label, multicenter, multinational study to assess the feasibility of switching therapy from pramipexole or ropinirole to the rotigotine transdermal system and its effect on motor and non-motor symptoms in subjects with advanced idiopathic Parkinson’s disease (Funded by Quintiles 2012/13).
  • Principal Investigator. LRRK2 genetic variants and caffeine in Parkinson’s disease. NIG / NMRC grant $200,000. (NIG/NMRC 2012/14). 
  • Site Principal Investigator. A Longitudinal View of Apathy and Its Impact in Parkinson's disease. 
  • Principal Investigator. Non-motor symptoms in Parkinson’s disease. (CIRB: 2010/590/A).
  • Site Principal Investigator. Randomized pilot study on the effect of betahistine on cerebral blood flow and gait in subjects at risk of falling. (Funded by Abbott 2012/13) 

Selected Publications:

Wu J, Lim EC, Nadkarni NV, Tan EK, Prakash KM. The impact of levodopa therapy-induced complications on quality of life in Parkinson’s disease patients in Singapore. Scientific Reports. 2019 (ePub).

Tan MJM, Lim EC, Nadkarni NV, Lye WK, Tan EK, Prakash KM. The characteristics of patients associated with high caregiver burden in Parkinson’s disease in Singapore. Frontiers in Neurology-Movement Disorders. DOI: 10.3389/fneur.2019.00561.

Chew EGY, Tan LCS, Au WL, Prakash KM, Liu J, Foo JN, Tan EK. ITPKB and ZNF184 are associated with Parkinson’s disease risk in East Asians. Neurobiol Aging. 2019 (ePub)

Chew EGY, Liany H, Tan LCS, Au WL, Prakash KM, Annuar AA. Evaluation of novel Parkinson’s disease candidate genes in Chinese population. Neurobiol Aging. 2019;74:235.e1-235.

Lu ZH, Ng S, Huang SS, Ng E, Parimelalagan, Setiawan F, Tan L, Prakash KM. Evalaution of the relationship between Leucine-rich repeat kinase 2 (LRRK2) S 1647T variants and smoking with risk of Parkinson’s disease in Singapore population [abstract]. Mov Disord. 2018;33:S601-602.

Foo JN, Tan LC, Au WL, Prakash KM, Liu J, Tan EK. No association of DNM3 with age of onset in Asian Parkinson’s disease. Eur J of Neurol. 2018. Aug 22 (ePub).

Tan D, Puan YH, Balakrishnan S, Scully A, Bower KJ, Prakash KM, Tan EK, Chew JS, Poh E, Tan SB, Clark RA. Automated analyis of gait and modified timed up and go using the Microsoft Kinect in people with Parkinson’s disease: associations with physical outcome measures. Med  Biol Eng Comput. 2019. 57(2):369-77.

Ng ASL, Ng EYL, Tan YJ, Prakash KM, Au WL, Tan LCS, Tan EK. Case –control analysis of LRRK2 protective variants in essential tremor. Sci Rep. 2018. 28;8(1):5346.

Foo JN, Tan LC, Irwan ID, Au WL, Low HQ, Prakash KM, Ahmad-Annuar A, Bei J, Chan AY, Chen CM, Chen YC, Chung SJ, Deng H, Lim SY, Mok V, Pang H, Pei Z, Peng R, Shang HF, Song K, Tan AH, Wu YR, Aung T, Cheng CY, Chew FT, Chew SH, Chong SA, Ebstein RP, Lee J, Saw SM, Seow A, Subramaniam M, Tai ES, Vithana EN, Wong TY, Heng KK, Meah WY, Khor CC, Liu H, Zhang F, Liu J, Tan EK. Genome-wide association study of Parkinson's disease in East Asians. Hum Mol Genet. 2017 Jan;26(1):226-232. 

Chao YX, Lin Ng EY, Tio M, Kumar P, Tan L, Au WL, Yih Y, Tan EK. Essential tremor linked TENM4 mutation found in healthy Chinese individuals. Parkinsonism Relat Disord. 2016 Oct;31:139-140.

Prakash KM, Nadkarni NV, Lye WK, Yong MH, Chew LM, Tan EK. The impact of non-motor symptoms on the quality of life of Parkinson’s disease patients: a longitudinal study. Eur J Neurol. 2016 May;23(5):854-60.

Foo JN, Chung SJ, Tan LC, Liany H, Ryu HS, Hong M, Koh TH, Irwan ID, Au WL, Prakash KM, Aung T, Cheng CY, Chong SA, Khor CC, Lee J, Tai ES, Vithana EN, Wong TY, Song K, Liu J, Tan EK. Linking a genome-wide association study signal to a LRRK2 coding variant in Parkinson's disease. Mov Disord. 2016 Apr;31(4):484-7.

Kumar PM, Paing SS, Li H, Pavanni R, Yuen Y, Zhao Y, Tan EK. Differential effect of caffeine intake in subjects with genetic susceptibility to Parkinson's Disease. Sci Rep. 2015 Nov 2;5:15492.

Deng X, Xiao B, Li HH, Lo YL, Chew LM, Prakash KM, Tan EK. Sexual dysfunction is associated with postural instability gait difficulty subtype of Parkinson's disease. J Neurol. 2015 Nov;262(11):2433-9.

Prakash KM, Nadkarni NV, Lye WK, Yong MH, Chew LM, Tan EK. A longitudinal study of non-motor symptom burden in Parkinson's disease after a transition to expert care. Parkinsonism Relat Disord. 2015 Aug;21(8):843-7.

Chao YX, Ng EY, Li H, Nagaendran K, Yih Y, Chong MS, Prakash KM, Tan L, Au WL, Zhao Y, Zhou ZD, Tio M, Pavanni R, Tan EK. Association Analysis of COQ2 Variant in Dementia and Essential Tremor. Parkinsons Dis. 2015;2015:926280.

Chao YX, Ng EY, Tan L, Prakash KM, Au WL, Zhao Y, Tan EK. Lrrk2 R1628P variant is a risk factor for essential tremor. Sci Rep. 2015 Mar 12;5:9029.

Foo JN, Liany H, Tan LC, Au WL, Prakash KM, Liu J, Tan EK. DNAJ mutations are rare in Chinese Parkinson's disease patients and controls. Neurobiol Aging. 2014;35(4):935. e1-2.

Foo JN, Tan LC, Liany H, Koh TH, Irwan ID, Ng YY, Ahmad-Annuar A, Au WL, Aung T, Chan AY, Chong SA, Chung SJ, Jung Y, Khor CC, Kim J, Lee J, Lim SY, Mok V, Prakash KM, Song K, Tai ES, Vithana EN, Wong TY, Tan EK, Liu J. Analysis of non-synonymous-coding variants of Parkinson's disease-related pathogenic and susceptibility genes in East Asian populations. Hum Mol Genet. 2014;23(14):3891-7.

Ting SK, Hameed S, Prakash KM. Ganser Symptoms in a Chinese Speaking
Corticobasal Syndrome (CBS) Patient. Ann Acad Med Singapore. 2014;43(3):197-9.

Wu YR, Foo JN, Tan LC, Chen CM, Prakash KM, Chen YC, Bei JX, Au WL, Chang CW, Wong TY, Liu JJ, Zhao Y, Tan EK. Identification of a novel risk variant in the FUS gene in essential tremor. Neurology. 2013 Aug 6;81(6):541-4.

Foo JN, Liany H, Bei JX, Yu XQ, Liu J, Au WL, Prakash KM, Tan LC, Tan EK. A rare lysosomal enzyme gene SMPD1 variant (p.R591C) associates with Parkinson's disease. Neurobiol Aging. 2013 Dec;34(12):2890.e13-5.

Seng Ting SK, Chong MS, Kandiah N, Hameed S, Tan L, Au WL, Prakash KM, Pavanni R, Lee TS, Foo JN, Bei JX, Yu XQ, Liu JJ, Zhao Y, Lee WL, Tan EK. Absence of A673T amyloid-β precursor protein variant in Alzheimer's disease and other neurological diseases. Neurobiol Aging. 2013 Oct;34(10):2441.e7-8.

Tan EK, Foo JN, Tan LC, Au WL, Prakash KM, Ng E, Ikram MK, Wong TY, Liu J, Zhao Y. SLC1A2 variant associated with Essential Tremor but not Parkinson’s disease in Chinese. Neurology 2013 Apr 23;80(17):1618-9.

Yong MH, Allen JC, Prakash KM, Tan EK. Differentiating non-motor symptoms in Parkinson’s disease from controls and hemifacial spasm. PLoS One. 2013;8(2):e49596.

Peeraully T, Tan SF, Fook-Chong SM, Prakash KM, Tan EK. Headache in hemifacial spasm patients. Acta Neurol Scand. 2013 May;127(5):e24-7.

Zhao Y, Ho P, Prakash KM, Foo JN, Liu JJ, Au WL, Tan LC, Tan EK. Analysis of EIF4G1 in Parkinson's disease among Asians. Neurobiol Aging. 2013 Apr;34(4):1311.e5-6.

Zhao Y, Gopalai AA, Ahmad-Annuar A, Teng EW, Prakash KM, Tan LC, Au WL, Li HH, Lim SY, Lim SK, Chong YB, Tan LP, Ibrahim NM, Tan EK. Association of HLA locus variant in Parkinson's disease. Clinical Genetics. 2013 Nov;84(5):501-4.

Yip CW, Cheong PW, Green A, Prakash PK, Fook-Cheong SK, Tan EK, Lo YL. A prospective pilot study of repetitive transcranial magnetic stimulation for gait dysfunction in Vascular Parkinsonism. Clin Neurol Neurosurg. 2013 Jul;115(7):887-91.

Wu YR, Tan LC, Fu X, Chen CM, Au WL, Chen L, Chen YC, Prakash KM, Zheng Y, Lee-Chen GJ, Zhao Y, Zeng JS, Tan EK, Pei Z. LRRK2 A419V is not associated with Parkinson's disease in different Chinese populations. PLoS One. 2012;7(7):e36123.

Ahmad MT, Hameed S, Prakash KM. Spontaneous Intracranial Hypotension with Bilateral Subdural Hemorrhage: Is Conservative Management Adequate? Annals of Indian Academy of Neurology. 2013 Jan;16(1):94-6.