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Despite glaucoma being the world’s leading cause of permanent blindness, very little is understood about the role of casual genes and how they initiate and drive glaucoma pathogenesis. Dr. Wang’s group takes naturally occurring risk-associated genetic coding variants uncovered in large, multi-ethnic cohorts of glaucoma patients, and performs functional characterization to deeply understand glaucoma disease mechanisms. The group utilises a variety of orthogonal approaches- ranging from classic molecular biology techniques to multi-omics strategies - to understand variant gene function. The knowledge gained from these studies will be used to predict individual risk of glaucoma, and to develop new glaucoma subtype-specific therapeutic strategies.

 

1. Z Li*, Wang Z*, MC Lee*, M Zenkel*, KLE Peh, M Ozaki, F Topouzis, S Nakano, A Chan, S Chen, SEI Williams, A Orr, M Nakano, N Kobakhidze, T Zarnowski, AP Cherecheanu, T Mizoguchi, S Manabe, K Hayashi, S Kazama, K Inoue, Y Mori, K Miyata, K Sugiyama, T Higashide, E Chihara, R Ideta, S Ishiko, A Yoshida, K Tokumo, Y Kiuchi, T Ohashi, T Sakurai, T Sugimoto, H Chuman, M Aihara, M Inatani, K Mori, Y Ikeda, M Ueno,  D Gaston, P Rafuse, L Shuba, J Saunders, M Nicolela, G Chichua, S Tabagari, P Founti, KS Sim, WY Meah, HM Soo, XY Chen, A Chatzikyriakidou, C Keskini, T Pappas, E Anastasopoulos, A Lambropoulos, ES Panagiotou, DG Mikropoulos, E Kosior-Jarecka, A Cheong, YH  Li, U Lukasik, ME Nongpiur, R Husain, SA Perera, L Álvarez, M García, H González-Iglesias, AF Cueto, LFV Cueto, F Martinón-Torres, A Salas, C Oguz, N Tamcelik, E Atalay, B Batu, M Irkec, D Aktas, B Kasım, YS Astakhov, SY Astakhov, EL Akopov, A Giessl, C Mardin, C Hellerbrand, JNC Bailey, RP Igo, Jr., JL Haines, DP Edward, S Heegaard, S Davila, P Tan, JH Kang, LR Pasquale, FE Kruse, A Reis, TR Carmichael, M Hauser, M Ramsay, G Mossböck, N Yildirim, K Tashiro, AGP Konstas, M Coca-Prados, JN Foo, S Kinoshita, C Sotozono, T Kubota, M Dubina, R Ritch, JL Wiggs, F Pasutto, U Schlötzer-Schrehardt, YS Ho, T Aung, WL Tam, CC Khor  (2021). Association of Rare CYP39A1 Variants With Exfoliation Syndrome Involving the Anterior Chamber of the Eye. The Journal of the American Medical Association ; 325(8):753-764. IF: 157.38

2. Wang Z*, Yip LY*, JHJ Lee, Z Wu, HY Chew, PKW Chong, CC Teo, YKH Ang, KLE Peh, , J Yuan, LSK Choo, N Basri, Jiang X, Q Yu, A Hillmer, EH Tan, D Tan, Takano A, YS Ho, B Lim and WL Tam (2019). Methionine is a metabolic dependency of tumor-initiating cells. Nature Medicine ; 25(5):825-837 IF:87.24


3. Wang Z#, Wiggs, JL, Aung T, Khawaja AP, Khor CC (2022). The genetic basis for adult-onset glaucoma: Recent advances and future directions. Progress in Retinal and Eye Research ; 2022 May 17;101066 IF:19.704 # Corresponding Author